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The Bright Side of Muni Market Volatility: Tax-Loss Harvesting

Tradeweb

The uncertainty around the timing of interest rate hikes these past two years has created an opportunity that municipal bond investors haven’t seen in a decade – gaining by losing. What we mean is tax-loss harvesting, a strategy rarely available to this market given munis’ historic stability and, more recently, the extended bull market run in bonds that preceded this latest Fed tightening cycle. Now, with less than a month left before year’s end, we’re seeing strong evidence that institutional and retail investors are taking advantage of recent yield volatility to book these advantageous losses. The volume of bid wanted lists on the Tradeweb platform spiked in November and continues to run 70% higher than August year-to-date activity, prior to the temporary blip in municipal bond performance. Through the first eight months of 2023, total returns in the muni market were positive, so tax-harvesting as a widely available strategy stayed on the shelf. However, with the market losing more than 3% in October and turning negative for 2023, investors could again consider the strategy to manage tax liabilities while dumping underperforming bonds. Investors had a similar opportunity to pursue tax-loss harvesting at the end of 2022, set up by a comparable spike in yields last September. A surge in activity For those who haven’t been around munis long enough to experience past downturns, tax harvesting might be an unfamiliar concept. The idea is simple tax management - investors sell securities with unrealized capital losses to offset realized capital gains. Those losses that exceed the gains in a given year can be carried forward to offset gains in future tax years. Since September, we have seen institutions and retail investors alike pursuing the strategy in earnest. Evidencing this trend, users of Tradeweb Direct’s Portfolio Solutions analytics suite conducted holdings searches to identify municipal positions with unrealized losses in the month of September at a clip 82% higher than in the preceding eight months. What’s more, muni bid wanteds routed through Tradeweb Direct have also spiked, with October sell inquiries 65% greater than the August year-to-date average and November liquidation requests soaring 70% above that level. Retail is on board Given the dynamic role and high levels of participation of retail investors in the municipals market that’s not at all surprising. Retail investors are crucial to creating a high-functioning muni market and have themselves become more sophisticated, active market investors. They own roughly 60-70% of all municipal bonds outstanding, and are no longer just the buy-and-hold investor of last resort. Through advances in electronic trading, they’ve gained a direct conduit to the institutional sell side, and represent a big pool of market liquidity in both volatile and stable markets. The tricky part of tax-loss selling for any investor comes when it’s time to reinvest. While buying similar securities - often to maintain portfolio allocations - is ok, IRS “wash rules” prohibit the purchase of substantially the identical investment within 30 days before or after the sale. Because liquidity in the muni market is largely driven by available inventory, finding a similar replacement manually for the asset that was sold can sometimes be a challenge. There are tools, though, that can help with the transaction and with locating a qualified replacement. Leveraging the Portfolio Solutions analytics suite on Tradeweb Direct, investors can pursue tax-loss harvesting electronically, using features that support the end-to-end workflow of the strategy. Here’s how to get started: 1) Identify your loss candidates 2) Add a swap candidate to a restructuring proposal 3) Add a replacement candidate to the proposal 4) Generate a client-facing transaction report As we’ve seen through periods of bond market volatility these past two years, sudden swings in yields present opportunities to use negative returns to your advantage. The windows open and close quickly, so being prepared, with the tools to enable fast execution, is essential. With year-end approaching and interest rates top of mind, it’s important to stay vigilant and move on tax-loss harvesting possibilities when they are available. To learn more about Tradeweb Direct’s capabilities and how we can assist you in your trading strategies, visit: https://www.tradeweb.com/our-markets/tradeweb-direct-middle-markets--retail/. Written by: Bill Buzaid, Managing Director, Head of Sales & Relationship Management, Tradeweb Direct and Alexandra Isayev, Director, Head of Portfolio Solutions Product, Tradeweb Direct © 2023 Tradeweb Markets LLC. The information contained herein is proprietary and may not be copied or redistributed without the prior written consent of Tradeweb Markets LLC. The content of this publication is for informational purposes only and is not offered as investment, tax or legal advice, or an offer to buy or sell securities. The information is provided “as is” and to the fullest extent permitted by applicable law, all warranties and representations are disclaimed. About Tradeweb Markets Tradeweb Markets Inc. (Nasdaq: TW) is a leading, global operator of electronic marketplaces for rates, credit, equities and money markets. Founded in 1996, Tradeweb provides access to markets, data and analytics, electronic trading, straight-through-processing and reporting for more than 40 products to clients in the institutional, wholesale and retail markets. Advanced technologies developed by Tradeweb enhance price discovery, order execution and trade workflows while allowing for greater scale and helping to reduce risks in client trading operations. Tradeweb serves more than 2,500 clients in more than 65 countries. On average, Tradeweb facilitated more than $1.2 trillion in notional value traded per day over the past four quarters. For more information, please go to www.tradeweb.com. Forward-Looking Statements This release contains forward-looking statements within the meaning of the federal securities laws. Statements related to, among other things, our outlook and future performance, the industry and markets in which we operate, our expectations, beliefs, plans, strategies, objectives, prospects and assumptions and future events are forward-looking statements. We have based these forward-looking statements on our current expectations, assumptions, estimates and projections. While we believe these expectations, assumptions, estimates and projections are reasonable, such forward-looking statements are only predictions and involve known and unknown risks and uncertainties, many of which are beyond our control. These and other important factors, including those discussed under the heading “Risk Factors” in documents of Tradeweb Markets Inc. on file with or furnished to the SEC, may cause our actual results, performance or achievements to differ materially from those expressed or implied by these forward-looking statements. Given these risks and uncertainties, you are cautioned not to place undue reliance on such forward-looking statements. The forward-looking statements contained in this release are not guarantees of future performance and our actual results of operations, financial condition or liquidity, and the development of the industry and markets in which we operate, may differ materially from the forward-looking statements contained in this release. In addition, even if our results of operations, financial condition or liquidity, and events in the industry and markets in which we operate, are consistent with the forward-looking statements contained in this release, they may not be predictive of results or developments in future periods. Any forward-looking statement that we make in this release speaks only as of the date of such statement. Except as required by law, we do not undertake any obligation to update or revise, or to publicly announce any update or revision to, any of the forward-looking statements, whether as a result of new information, future events or otherwise, after the date of this release. Contact Details Tradeweb Media Contact Daniel Noonan +1 646-767-4677 Daniel.Noonan@Tradeweb.com Company Website http://www.tradeweb.com

December 06, 2023 09:51 AM Eastern Standard Time

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Longeveron (NASDAQ: LGVN) Announces Positive Top-Line Results For Its Phase 2a Clinical Trial For The Treatment Of Mild Alzheimer’s Disease With Lomecel-B™

Benzinga

By Meg Flippin, Benzinga Longeveron Inc. (NASDAQ: LGVN), a clinical-stage biotech company aiming to address life-threatening and chronic aging-related conditions using cell therapies, continues to make positive progress. The company just reported positive top-line results from its phase 2a trial of Lomecel-B™, its investigational product, for the treatment of mild Alzheimer’s disease. In the trial of 48 patients ages 60 to 85 years old with mild Alzheimer’s disease, Lomecel-B™ met its primary safety endpoint and also showed statistically significant evidence of slowing disease progression as compared to placebo. “We believe these results provide important validation of both the safety and therapeutic potential of Lomecel-B™ in the treatment of Alzheimer’s disease and provide a robust foundation for additional clinical trials in this and other indications,” Wa’el Hashad, Chief Executive Officer of Longeveron, said when announcing the phase 2a trial results. “We look forward to announcing additional biomarker data from this trial which may further characterize the clinical effects of Lomecel-B™ in this study population.” Targeting Neurodegeneration And Inflammation Lomecel-B™ is made from medical signaling cells (MSCs) derived from the bone marrow of young, healthy adult donors. It is believed that MSCs travel to sites of damage or inflammation in the body and may promote cellular regeneration. The promising results of its phase 2a trial come as the world reaches an inflection point with Alzheimer’s disease. About 6.7 million people ages 65 and older in the U.S. suffer from the disease. It’s only expected to get worse as the population continues to age. By 2060, it has been projected that Alzheimer’s disease may affect 14 million people in the U.S. Lomecel-B™’s Potential For Other Conditions? That’s not the only opportunity for Longeveron and Lomecel-B™. The experimental therapeutic treatment is also in phase 2 trials to treat Hypoplastic Left Heart Syndrome (HLHS) and Aging-related Frailty. HLHS is a rare congenital heart defect in which the left side of the heart fails to develop, leading to short-term mortality, delayed development and long-term organ failure. HLHS affects about 1,000 babies in the U.S. annually and requires a three-stage open-heart surgery to survive, and even with the surgeries, early mortality and need for heart transplantation are still extremely high due to right ventricle failure. As a result, there is an important unmet medical need to improve right ventricular function in these patients – and that’s where Lomecel-B™ may potentially be effective. Administered directly into the cardiac tissue of the right ventricle during the second stage of the surgery – when the child is around four months old – the goal is to improve right ventricular function through the potential regenerative, pro-vascular and anti-inflammatory effects of MSCs. Results from Longeveron’s phase 1 ELPIS 1 trial showed 100% survival in Lomecel-B™ treated patients for up to five years. Based on the results achieved to date, Lomecel-B™ has received Rare Pediatric Disease Designation (RPD), Orphan Drug Designation (ODD), and Fast Track designation from the United States Food and Drug Administration (FDA). Longeveron’s 38-patient phase 2 trial is currently underway. In August, the trial passed the 50% enrollment threshold. To expedite the completion of the trial enrollment, an additional clinical site was also added. Aging – A Growing Problem Lomecel-B™ is also in phase 2 trial to treat Aging-related Frailty, which is characterized by mobility disability, weakness, fatigue, weight loss, slowness and low activity. People with Aging-related Frailty are also more prone to develop infections, suffer from falls and require hospitalization. There are no approved treatments for Aging-related Frailty, but Longeveron hopes that its experimental product may gain approval as a potential treatment. Lomecel-B™ is currently being tested in a phase 2 trial of 45 patients in Japan, where nearly a third of the population is over the age of 65. In a previous phase 2b trial, a single intravenous (IV) infusion of Lomecel-B™ was shown to improve walking distance during a six-minute walk test after nine months. If greenlighted, Lomecel-B™ could become the first FDA-approved treatment in the U.S. for Aging-related Frailty, addressing an unmet need that appears likely to increase as the population ages. Email: mmoyer@lifesciadvisors.com Investor Contact Mike Moyer LifeSci Advisors Tel: 617-308-4306 This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Forward-Looking Statements Certain statements in this press release that are not historical facts are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, which reflect management’s current expectations, assumptions, and estimates of future operations, performance and economic conditions, and involve risks and uncertainties that could cause actual results to differ materially from those anticipated by the statements made herein. Forward-looking statements are generally identifiable by the use of forward-looking terminology such as “believe,” “expects,” “may,” “looks to,” “will,” “should,” “plan,” “intend,” “on condition,” “target,” “see,” “potential,” “estimates,” “preliminary,” or “anticipates” or the negative thereof or comparable terminology, or by discussion of strategy or goals or other future events, circumstances, or effects. Factors that could cause actual results to differ materially from those expressed or implied in any forward-looking statements in this release include, but are not limited to, the anticipated use of proceeds from the offering, as well as statements about the ability of Longeveron’s clinical trials to demonstrate safety and efficacy of the Company’s product candidates, and other positive results; the timing and focus of the Company’s ongoing and future preclinical studies and clinical trials and the reporting of data from those studies and trials; the size of the market opportunity for the Company’s product candidates, including its estimates of the number of patients who suffer from the diseases being targeted; the success of competing therapies that are or may become available; the beneficial characteristics, safety, efficacy and therapeutic effects of the Company’s product candidates; the Company’s ability to obtain and maintain regulatory approval of its product candidates in the U.S., Japan and other jurisdictions; the Company’s plans relating to the further development of its product candidates, including additional disease states or indications it may pursue; the Company’s plans and ability to obtain or protect intellectual property rights, including extensions of existing patent terms where available and its ability to avoid infringing the intellectual property rights of others; the need to hire additional personnel and the Company’s ability to attract and retain such personnel; the Company’s estimates regarding expenses, future revenue, capital requirements and needs for additional financing; the Company’s need to raise additional capital, and the difficulties it may face in obtaining access to capital, and the dilutive impact it may have on its investors; market and other conditions; the Company’s financial performance and ability to continue as a going concern, and the period over which it estimates its existing cash and cash equivalents will be sufficient to fund its future operating expenses and capital expenditure requirements. Further information relating to factors that may impact the Company’s results and forward-looking statements are disclosed in the Company’s filings with the Securities and Exchange Commission, including Longeveron’s Annual Report on Form 10-K for the year ended December 31, 2022, filed with the Securities and Exchange Commission on March 14, 2023 and its Quarterly Report on Form 10-Q for the third quarter of 2023 filed with the SEC on November 9, 2023. The forward-looking statements contained in this press release are made as of the date of this press release, and the Company disclaims any intention or obligation, other than imposed by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

December 06, 2023 09:15 AM Eastern Standard Time

Amesite’s Investments In Infrastructure Enable A No-Setup Fee Deal For Its Customers, Enabling Risk-Free Scale And Simplified Sales

Benzinga

By Meg Flippin, Benzinga Universities and small businesses play a big role in reskilling workers for the jobs of tomorrow, but many are forced to balance that responsibility with the costs associated with offering classes and training. In lots of cases, they can only offer the bare minimum. Amesite (NASDAQ: AMST) is helping level the playing field for higher education with its technology-forward no-risk approach. Thanks to advances in technology, the Detroit-based company that provides an online learning platform is able to deliver what it believes is the best deal in edtech. Instead of charging anywhere from $250,000 to $500,000 in set-up fees to edtech customers, Amesite has a no-fee model where customers pay monthly per user. That approach expands the market for Amesite and enables companies and universities to provide professional training without big upfront investments. “Now that we moved from an executive sale with a high setup fee to one with no fees it affords us the ability to reach a broader array of higher education partners and businesses,” said Amesite founder and CEO Dr. Ann Marie Sastry during the company’s recent shareholder update. Amesite says that it also gives the company a more predictable revenue stream with users paying a fixed fee per month per course. The sales process is also made easier because of the lack of startup costs. That has created a much more efficient sales cycle for Amesite, and the company says sales-qualified leads have seen a nearly 200% increase from the first quarter of 2023 to the first quarter of 2024. “We’re extremely busy and extremely excited about our ability to execute in that segment,” said Sastry. Speed Gives Amesite An Edge All of this is made possible thanks to Amesite’s technology-first approach aimed at improving the outcomes of learners. With its platform courses can be added quickly, programs are adaptable and users stay engaged. In one example, Amesite was able to onboard 50 courses in four days for EWIE Group of Companies, a commodity management company that provides training to more than 1,000 employees located around the globe. Its old platform fell way short when it came to engagement, but that changed with Amesite. Less than a quarter after courses began, employee scores were 91%, against a target of 70% for passing. That speed is rare in the e-learning industry and is made possible thanks partly to Amesite’s partnership with Microsoft Corp.’s (NASDAQ: MSFT) Azure cloud unit. By migrating its application to Azure infrastructure and its data to Azure Database for PostgreSQL, Amesite can now onboard customers in 24 hours or less and can easily scale up – all at half the infrastructure cost. Harnessing The Power Of AI Amesite also leverages GPT-4 – the AI system powering Bing and ChatGPT Plus – to offer AI capabilities such as learning and creative assistants, educational games, interactive learning experiences, leaderboards and other learning incentives to keep students engaged. Amesite’s V6 can integrate thousands of application programming interfaces (API), which means it works with most companies and schools’ programs. Thanks to AI and Azure, Amesite can offer tailored e-learning solutions in partnership with customers, making sure workers and students have access to the latest tech and the most up-to-date content whether it changes daily, weekly, monthly or yearly. More Growth On The Horizon All of that presents a potential opportunity for investors looking to get exposure to the online learning market, which is projected to reach a value of $602 billion by 2030, growing at a CAGR of 17.2% over 2023-2030. With $5.4 million in cash in the bank, Amesite seems to be well-positioned to expand its platform and add more cutting-edge technology, all while keeping costs down. It’s the reason the company is seeing double-digit revenue growth – in Q2 2023 Amesite reported a 21.96% increase in revenue year-over-year. The need to retrain workers and educate new ones is growing as companies wrestle with the ever-changing skill requirements of the digital economy. Set-up costs are a major barrier for many edtech providers. Amesite is changing that with its no-fee no-risk offer. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

December 06, 2023 09:15 AM Eastern Standard Time

Minuteman Press Franchise in Londonderry, NH Wins Business of the Year

Minuteman Press International Inc

For over 8 years and counting, Bob Bean has been the proud owner of the Minuteman Press franchise in Londonderry, New Hampshire located at 44 Nashua Road, Unit 18. When Bob purchased the business in October of 2015, he followed the Minuteman Press system and immediately became involved with several community groups and organizations. Thanks to Bob’s hard work and dedication, Minuteman Press in Londonderry has won the Business of the Year award from the Greater Derry Londonderry Chamber of Commerce. Bob accepted the award at the special awards dinner that was held on Oct. 12, 2023 at the Tupelo Music Hall in Derry NH. Bob shares his humble reaction to winning the award and provides his insights on the importance of being an active member of local groups in order to build relationships and generate referrals. He also talks about his journey to Minuteman Press and how his passion for helping others drives him today. What does it mean to you to win Business of the Year? H ow are you active in your community? Bob Bean: “Receiving the Business of the Year is a humbling experience. It was a surprise, I did not know that we had made such an impact in the Chamber and business community for this recognition. We have just tried to provide services to the businesses and the community to the best of our ability. It is great to be recognized and know that we are doing a good job with in the communities that we serve. I am involved in two local Chambers, member of the Rotary Club of Londonderry, and have been an active member in BNI for 8 years. I have made many connections with a lot of the non-profits in the area and work with them to help with their needs and support their functions. With the local rotary we have sponsored Christmas on the Commons, Senior High School Graduation Banners have donated to many non-profits and helped with fuel assistance during the winter months. I am also involved with the Freemasons in the state.” How would you best describe your community? Bob Bean: “ The Derry/Londonderry community are the largest two towns that are in the chamber and we have several smaller towns in the chamber also. New Hampshire does not have a lot of large metropolitan areas; it is made up more of small towns that are convenient to bordering states. Other than small businesses and small business owners, the majority of the communities are made up of people that work out of state. The people and businesses in the community are open and always look for ways to help each other when possible. As business owners, we all want to support each other and do what we can to see that we can grow and thrive.” What are some of the key ways you’ve grown your business? Bob Bean: “Networking is the key that has worked for us. Since 2015, I have been a member of the chamber and of BNI. I have always been very active in the networking area by going to meetings, ribbon-cuttings, events, and visiting businesses. We took advantage of the upgraded minuteman.com website to get some traffic through online channels. One of the other biggest ways we’ve built the business is through referrals from our customers and the organizations we work with.” What are your high-demand products and services? Bob Bean: “We have been able to provide direct mail services for many of our clients; this has been a big part of the business over the last few years especially during the pandemic. We also do a lot of marketing catalogs and Playbills for several theater groups and music groups.” What was your previous background? Why did you choose Minuteman Press? Bob Bean: “I was in the computer industry for almost 40 years. Most of my career was in management both in manufacturing and support. I was a Field Service Representative for a computer company for many years. Then, for 20 years, I was a Technical Support Manager for a supermarket chain. I chose Minuteman Press because of the research I did on the company and talking to the Regional Vice President and several store owners.” What has the support from Minuteman Press been like for you? Bob Bean: “Minuteman Press International support has been good on all levels. When I have a question, we can usually get an answer quickly. When there is an issue, support has been good at assisting in resolving the issue.” What are the biggest personal and professional rewards of owning your business? Bob Bean: “Personal and professional goals are similar in that I enjoy helping people and organizations. This business has given me the chance to connect with many more people and organizations to be able to help and give my knowledge and experience to them so that they can succeed.” What advice would you give to other business owners right now? Bob Bean: “Get involved with your local Chamber of Commerce and BNI Networking Group. These two are very critical to the growth and success of the business. Also, look into other organizations and groups like the Exchange, Rotary, Kiwanis, or whatever is in your area and local to your business. But do not just join these groups; get involved and be active in what is going on with the groups and be involved in the community. You get out of them what you put into them, so if you are active and visible then you will be the person or business that others will seek out and rely on for help and advice.” For more information on Minuteman Press in Londonderry, NH, visit https://minuteman.com/us/locations/nh/londonderry/ Learn more about #1 rated Minuteman Press franchise opportunities and read Minuteman Press franchise reviews at https://minutemanpressfranchise.com. Contact Details Minuteman Press International Chris Biscuiti +1 631-249-1370 cbiscuiti@mpihq.com Company Website https://minutemanpressfranchise.com

December 06, 2023 09:10 AM Eastern Standard Time

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AmeraMex International Receives Orders Totaling $780,000

Ameramex International

AmeraMex International, Inc. (OTC:AMMX), a provider of heavy equipment for logistics companies, infrastructure construction and forestry conservation, announced that it has received equipment orders totaling approximately $780,000. AmeraMex CEO Lee Hamre commented, “This quarter we have closed approximately $4.4 million in equipment order and a $1 million rental agreement. Today’s orders consist of a refurbished Taylor Equipment Forklift with a 36,000-pound lift capacity, 12 new LiuGong Forklifts with a 7,000-pound lift capacity, and a refurbished Taylor Equipment Empty Container Handler. The equipment is shipping to customers from Washington State down through Southern California,” added Hamre. LiuGong Forklift For more information and pricing of equipment for the logistics, construction, and forestry industries, or to book a demonstration of the First Green Industry’s 100 percent electric skid steer loaders, ASV Posti-Tract and Skid Steer Loaders, Menzi Muck Excavators or a Magni Telescopic Handler, contact the AmeraMex/Hamre Equipment sales team at 530.895.8955. About AmeraMex International AmeraMex International sells, leases and rents heavy equipment to companies within multiple industries including construction, logistics, mining, and lumber. AmeraMex, with a US and international customer base, has over 30 years of experience in heavy equipment sales and service. Follow AmeraMex on Twitter @ammx_intl and visit the AmeraMex website, www.AMMX.net or www.hamreequipment.com for additional information and equipment videos. Forward-Looking Statements This press release contains forward-looking statements. All statements other than statements of historical facts included in this press release are forward-looking statements. In some cases, forward-looking statements can be identified by words such as "believe," "expect," "anticipate," "plan," "potential," "continue" or similar expressions. Such forward-looking statements include risks and uncertainties, and there are key factors that could cause actual results to differ materially from those expressed or implied by such forward-looking statements. Investors are encouraged to review the Company’s filings with the Securities and Exchange Commission. Investors should not place any undue reliance on forward-looking statements since they involve known and unknown, uncertainties and other factors which are, in some cases, beyond the Company’s control which could, and likely will, materially affect actual results, levels of activity, performance or achievements. Any forward-looking statement reflects the Company’s current views with respect to future events and is subject to these and other risks, uncertainties and assumptions relating to operations, results of operations, growth strategy and liquidity. The Company assumes no obligation to publicly update or revise these forward-looking statements for any reason, or to update the reasons actual results could differ materially from those anticipated in these forward-looking statements, even if added information becomes available in the future. Contact Details McCloud Communications LLC Marty Tullio +1 949-632-1900 marty@mccloudcommunications.com Company Website https://www.ammx.net

December 06, 2023 09:10 AM Eastern Standard Time

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Personal Injury Attorney, Paul Greenberg Discusses PTSD from Dog Bite Trauma with the Chicago Sun-Times

Prodigy Press Wire

Chicago, Illinois – Briskman Briskman & Greenberg, a leading Chicago personal injury law firm, has been seeking justice for injury victims for over 30 years. Paul Greenberg, a partner at the firm, recently sat down with the Chicago Sun-Times to discuss an overlooked consequence of dog bites: Post-Traumatic Stress Disorder (PTSD). According to the Mayo Clinic, Post-Traumatic Stress Disorder (PTSD) is a mental health condition that’s triggered by a terrifying event — either experiencing it or witnessing it. Symptoms may include flashbacks, nightmares, severe anxiety, and intrusive thoughts about the event that cause significant problems in social or work situations and in relationships. PTSD can also interfere with the individual’s ability to go about their normal daily tasks. The condition may last for months or even years, with triggers that bring back memories of the trauma accompanied by intense emotional and physical reactions. While injuries and disfigurement from a dog bite are visible and immediate, the psychological scars left behind are often downplayed or overlooked. “Victims of dog bites will more often than not develop some post-traumatic stress disorder,” Greenberg explained. “The impact of this trauma can drastically alter the quality of life for victims.” In the article, the Sun-Times highlights the case of Nakia Childs, 48, who experienced acute PTSD after being bitten by a dog in her workplace. Once known as the “dog whisperer”, Nakia’s interaction with dogs is now riddled with fear. With the help of Briskman Briskman & Greenberg, she was able to secure monetary recovery for her dog bite injuries, but the recovery from trauma is a journey that she continues to navigate. Financial recovery can be a complex process, particularly if the dog owner is unknown or uninsured. Unlike car insurance, homeowner’s or renter’s insurance isn’t legally required, which can complicate matters for victims seeking compensation. The attorneys at Briskman Briskman & Greenberg are drawing attention to the silent epidemic of PTSD after dog bites, advocating for victims and ensuring they receive the justice they deserve. Paul Greenberg’s conversation with the Sun-Times not only raises awareness about the psychological scars of dog bites, but also underlines the need for legal support for victims grappling with the after-effects of such experiences. As the conversation around mental health continues to evolve, so too does the legal landscape surrounding personal injury and trauma. The attorneys at Briskman Briskman & Greenberg have successfully represented individuals and families who have been injured or lost loved ones as the result of someone’s carelessness or a workplace accident. We have achieved success in thousands of cases, recovering millions of dollars in damages for our clients in a wide variety of cases, including personal injury, car accidents, wrongful death, medical malpractice, pharmacy errors, dog bite injuries, and work injuries. Briskman Briskman & Greenberg 205 W Randolph St Suite 925 Chicago, IL 60606 (312) 222-0010 https://www.briskmanandbriskman.com/practice-areas/personal-injury/ Press Contact: Paul Greenberg Release ID: 832630

December 06, 2023 09:00 AM Eastern Standard Time

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HKBU-led research develops novel drug delivery system for Gouteng compound for Alzheimer’s disease treatment

Hong Kong Baptist University

HONG KONG SAR - Media OutReach Newswire - 6 December 2023 - A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer's disease (AD). The researchers have engineered exosomes, extracellular vesicles released by cells, to effectively carry the bioactive compound Corynoxine-B extracted from the Chinese herbal medicine Gouteng to the brain of mice with AD. As Corynoxine-B can induce autophagy, a process that maintains the health of cells, this new drug delivery system using exosomes can improve cognitive function and movement while reducing the symptoms of AD. The research findings have been published in the international academic journal Nature-Signal Transduction and Targeted Therapy. Bioactive compound of Gouteng can treat AD AD is the most common type of dementia in which the brain cells degenerate and die, characterised by a build-up of amyloid-beta and phospho-tau protein in the brain, resulting in the decline of the brain's cognitive functions. Currently more than 55 million people worldwide are dementia patients. In Hong Kong more than 100,000 elderly suffer from dementia and the number is anticipated to soar to more than 330,000 by 2039. At present there is no curative treatment for AD. Available treatments can only delay the disease's progression and improve symptoms. HKBU's previous research projects found that Corynoxine-B, a bioactive compound of Gouteng, is effective in treating AD. However, the blood-brain barrier which protects the brain from potentially harmful substances in the bloodstream affects its uptake in brain. Exosomes serve as drug carriers To tackle this problem, a research team comprising Professor Li Min, Associate Dean (Teaching and Learning) of Chinese Medicine, and Dr Ashok Iyaswamy, Research Assistant Professor of the Teaching and Research Division at the School of Chinese Medicine at HKBU, along with other local, mainland and overseas scientists, have developed a novel approach to deliver Corynoxine-B to the brain using exosomes. Exosomes are extracellular vesicles released by cells which can transport molecules between cells like nanocarriers. Recent studies have shown that they could be utilised as vehicles for drug delivery. To examine whether exosomes are effective drug carriers for AD, the researchers manipulated the neuronal cells in mice to overexpress an adaptor protein Fe65 on the surface of exosomes released by these cells. Fe65 is involved in the processing of amyloid-beta precursor protein (APP), which plays a crucial role in the development of AD. By doing so, they observed more exosomes containing Fe65 were released by the neuronal cells. These engineered exosomes showed a good ability to migrate towards the neuronal cells with APP overexpressed in AD models. These findings suggest that the presence of Fe65 on the surface of exosomes enhanced their ability to specifically target and interact with the neuronal cells with elevated levels of APP, which is a characteristic feature of AD. Reduction of accumulated amyloid-beta protein Corynoxine-B is a natural inducer of autophagy which plays a crucial role in maintaining neuronal health. The research team loaded it into the engineered exosomes and injected it to the mice with AD to evaluate its potential as a therapeutic agent for the disease. Results show that engineered exosomes loaded with Corynoxine-B could enhance autophagy in mice, and were able to cross the blood-brain barrier to deliver Corynoxine-B to the brain, resulting in a 30% reduction of accumulated amyloid-beta protein. In addition, various behavioural tests including the rotarod test, open field test, contextual fear conditioning test, and Morris's water maze test conducted on mice with AD showed that the application of engineered exosomes loaded with Corynoxine-B resulted in 25% recovery of the cognitive and locomotor behaviour. Professor Li Min said: "Our study suggests that exosomes could be a promising new way to deliver drugs to the brain and treat AD. More research is needed, but this study provides hope that a cure for AD may be possible in the future. We hope that this research project will ultimately be beneficial to the elderly, individuals at high risk of neurodegeneration and neurodegenerative disease patients." Contact Details Hong Kong Baptist University (HKBU) Christina Wu christinawu@hkbu.edu.hk

December 06, 2023 09:00 AM Eastern Standard Time

Green Lantern Solar Wins 2023 Solar Builder Community Solar Project of the Year Award for Innovative Brownfield Project

Green Lantern Solar

Green Lantern Solar, a leading renewable energy development and finance company focusing on commercial solar and energy storage systems, is the recipient of the 2023 Community Solar Project of the Year Award from Solar Builder. This accolade celebrates Green Lantern Solar’s outstanding achievement in completing a ground-mount net-metered community solar project situated on a challenging brownfield site at a former U.S. Air Force Station in St. Albans, Vt. Solar Builder is an industry-leading media outlet that focuses on the installation/construction of solar PV systems, covering the latest PV technology (modules, mounting, inverters, storage, BOS) and equipping installers/contractors with tips and tools to make informed purchasing decisions. Solar Builder’s Project of the Year Awards is a celebration of the solar industry’s achievements and dedication. The awards recognize the hard work of construction teams, the creativity of engineers, the leadership of developers and the commitment of local businesses, government agencies and nonprofits. Green Lantern Solar’s award-winning project, a 500 kW system featuring 1,700 ground-mounted panels, generates 892,000 kWh of clean energy annually, making a significant contribution to the region’s sustainable energy goals. “We are deeply honored to receive the 2023 Solar Builder Community Solar Project of the Year Award for our brownfield project on a former U.S. Air Force Station in Vt.,” said Scott Buckley, president of Green Lantern Solar. “This recognition underscores our unwavering commitment to advancing renewable energy solutions, even in the face of formidable site challenges. Our success is a testament to the dedication of our team and the resilience of our partners and community. We are proud to contribute to Vermont's sustainable future and look forward to continuing our mission of delivering clean energy solutions for a better tomorrow.” Originally scheduled to commence construction in March 2021, the project encountered various challenges, including commissioning delays. Despite these setbacks, Green Lantern Solar rallied its team and local contractors to persevere through a harsh Vermont winter, ensuring the project’s completion within the new timeline. The development of the project was complicated by the presence of contaminants on the brownfield site, necessitating the implementation of a Department of Environmental Conservation-approved soil management strategy. Vegetative management was conducted by hand using chainsaws to prevent any exposure to potentially contaminated soils in sensitive areas. Additionally, the project site, located atop a hill overlooking the city of St. Albans, consisted predominantly of solid rock, requiring drilling through rock for many of the racking posts and fence components. Portions of the site were also ballasted to safeguard the contaminated areas. Despite these formidable challenges, the project successfully met its March commissioning date, providing clean energy savings to the local community, including area farms benefiting from net metering credits. Furthermore, the project plays a pivotal role in helping Vermont achieve its Renewable Energy Standard target of 75 percent renewable energy by 2032. The system’s environmental impact is substantial, offsetting 632 metric tons of carbon dioxide emissions, equivalent to the reduction of 708,099 pounds of coal burned or the energy consumption of 79 homes for one year. “We extend our sincere appreciation to all of our esteemed partners, stakeholders and the dedicated local community for their steadfast support in transforming this award-winning project into a remarkable reality,” added Buckley. “We also congratulate all the nominees and honorees who have distinguished themselves in these prestigious awards.” The following organizations’ unwavering dedication and exceptional efforts were instrumental in the success of this award-winning project: APA Solar; Downs Rachlin Martin; E&S Electric Company; Green Mountain Power; Homestead Fence Company; Jeff Adams Excavating; Krebs & Lansing Consulting Engineers; Megawatt Group; Solar on Earth; Solar Power Engineering; Stone Environmental; Vermont Economic Development Authority and the Vermont Department of Environmental Conservation. About Green Lantern Solar Green Lantern Solar is a vertically integrated regional renewable energy development company with a particular emphasis on turn-key commercial solar solutions for municipal, education, healthcare and government entities. Green Lantern works with landowners to revitalize and re-develop low-value sites such as brownfields, landfills, quarries/pits/extraction sites and other challenging real estate. The company provides a full suite of services: development, financing, construction and operations, maintenance and asset management. For more information, visit www.greenlanternsolar.com on LinkedIn and @GrnLntrnSolar on X (Twitter). Contact Details Wilkinson + Associates Leah Wilkinson +1 703-907-0010 leah@wilkinson.associates Company Website https://www.greenlanternsolar.com/

December 06, 2023 08:48 AM Eastern Standard Time

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White Party Palm Springs Hits the Desert for its 34th Year with Electrifying New Developments

Full Scope PR

PALM SPRINGS, CA | December 6, 2023 White Party Global (WPG) is proud to announce the return of White Party Palm Springs 2024 for its 34 th year of celebrating the LGBTQ+ community through infectious music and dancing. Occurring March 29 -31 in Palm Springs, CA this iconic weekend attracts thousands of attendees from around the world. This year, the festival is offering earlier dates, exciting new venues, a fresh new Host Hotel, new pricing, and an expansive variety of musical styles sure to satisfy everyone’s musical taste. Get ready to hit the dance floor because this year it’s all about the music! “I spent a lot of time thinking about how to take White Party to the next level for 2024,” says White Party Global Executive Producer, Chris Diamond. “Over the years White Party has continued to evolve, while at the same time maintaining classic elements that have created its legendary status. Beyond a completely reimagined itinerary for the weekend, we curated an eclectic mix of DJs with something to suit everyone’s musical taste. In a year where everything is getting more expensive, we lowered our prices so everyone, especially our younger guests, can come and experience the community spirit, the joy and the music that is White Party! I look forward to seeing you on the dance floor in 2024!” The reimagined Palm Springs event has partnered with The Saguaro Palm Springs hotel for ticket holders where they will also throw their all-new pool party series throughout the weekend. White Party ticket purchasers will have access to hotel rooms featuring spectacular views and upgraded amenities, always making sure they’re only steps away from the weekend’s activities. Start the weekend off with a splash with the AQUA BOY pool party, an all-new event, poolside at the colorful Saguaro Palm Springs. Dance to the unique beats of DJs Jae Fusz and Sharon O’Love. This exciting new pool party series continues Saturday with SOAKIN’ WET! and Sunday with MERMEN! Break out the squirt guns and grab your tails because DJ Corey Craig and Grammy winning Producer/Remixer/DJ Dave Audé and Isis Muretech will heat you up and get you ready to take the plunge into a refreshing musical pool! Pivoting to the first nighttime event of the weekend, White Party Global is excited to announce its partnership with the groundbreaking brand Tom of Finland as together they kick off, ACHROMATICA, a black and white themed night you won’t forget. This sexy night of leather features DJs Mohammad and Nina Flowers and launches you on a fast-paced ride to start the weekend right. A brand-new venue sets the mood as the Margaritaville Resort ballroom is transformed to suit your pleasures. The main event of the weekend returns to the Palm Springs Convention Center like you’ve never seen it before. Prepare for an intimate vibe and sultry dance floor that will transport you to a mystical time and place called SAHARA DESERT NIGHTS. You will enter an enchanted land of riches and exotic décor as you are surrounded by state-of-the-art sound, blazing lasers, and lighting. Dress in traditional white or go all out with Exotic Desert White. Feel the magic all night with DJs TDon, Tomer Maizner and Karsten Sollors. In an homage to the Pharoahs of ancient Egypt, the PHAROAH T-DANCE floor becomes an otherworldly temple as you dance under the protective eye of the Pyramid to state-of-the-art sound, lighting, and videos. The gods are with you as DJs Dan Slater and GSP transport you to another time. Fireworks will dazzle as the night sky darkens and the true magic begins with a backdrop of the Palms Springs mountain range. The weekend culminates in a high-energy closing party with the FORBIDDEN world of DJ Abel at the Margaritaville Resort ballroom. Abel is prepared to take you on a journey all night long and into the wee hours of the morning. Just you, your friends, and the music you love. Additional special guests will be unveiled within the coming months. For all the latest information on the host hotel, weekend pass pricing, and event details, be sure to visit www.whitepartyglobal.com and follow us on social via Instagram and Facebook. White Party Palm Springs 2024 is powered by Ketel One, Wet Platinum, GAY PV, Commando, KGAY, Daiquiri Dick’s…on the beach, HomoCulture, and Crumble Catering. White Party Palm Springs 2024 is the premier destination for the ultimate LGBTQ+ Music Festival entering it’s unprecedented 34th year in the beautiful resort town of Palm Springs, California. 3 days and nights of 7 amazing parties are included in our VIP Weekend Pass featuring our White Party Global DJs, world class recording artists, and amazing specialty acts that will keep all our guests entertained all weekend long. Contact Details Full Scope PR Jack Ketsoyan whitepartypress@fullscopepr.com

December 06, 2023 08:40 AM Eastern Standard Time

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