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Investing in Innovation: Four Small-Caps Driving the Future of Pain Therapy

NTRB

The global transdermal patch market is quietly gaining ground. Valued at $7.8 billion in 2023, it is projected to reach nearly $10.95 billion by 2030. Within that, pain patches are leading the way, expected to grow from $4.8 billion in 2021 to $7.3 billion by 2031. But this growth is not just about convenience. Transdermal drug delivery is solving critical problems, from managing chronic pain in aging populations to delivering medications without needles. Most importantly, it offers a safer alternative to traditional opioid use. The abuse-deterrent opioid segment, while still relatively small, is gaining momentum. It is projected to more than double between 2024 and 2030, driven by regulatory pressure, clinical demand, and advances in technology. That convergence is starting to attract serious investor interest. This creates a promising setup for small-cap biopharma companies focused on innovative pain and rescue therapies. Several are moving closer to meaningful catalysts such as New Drug Application submissions and early-stage commercial progress. Here are a few stocks positioned to benefit from this overlooked but vital shift in drug delivery. Nutriband Inc. (NASDAQ: NTRB) is positioning itself as a disruptive force in the opioid pain management space with its lead product candidate, AVERSA Fentanyl, a transdermal patch designed to deter abuse, misuse, and accidental exposure. At the core of this innovation is Nutriband’s proprietary AVERSA technology, which leverages an aversive agent coating to address the most common form of fentanyl patch abuse—oral consumption. According to a 2022 market analysis by Health Advances, AVERSA Fentanyl has the potential to reach peak annual US sales of between 80 million and 200 million dollars. Unlike many early-stage biotechs, Nutriband is generating revenue today. Through its Pocono Pharma subsidiary, which produces kinesiology tape now sold in retail giants like Walmart, Walgreens, Target, and CVS, the company recorded 667 thousand dollars in revenue in the first quarter of 2025, a 63 percent year-over-year increase. This revenue stream helps fund development and reduces dilution risk, a key differentiator in a capital-intensive sector. Development of AVERSA Fentanyl continues to progress. Nutriband recently completed the commercial manufacturing process scale-up with its partner Kindeva Drug Delivery, a global CDMO that produces millions of transdermal patches annually. Together, they are preparing to file an Investigational New Drug application with the FDA, a crucial step ahead of the planned human abuse liability clinical study. The company is pursuing the 505(b)(2) pathway, which may allow for a faster and more efficient route to market. Regulatory momentum is supported by growing recognition of the public health risks tied to transdermal opioid misuse. AVERSA Fentanyl is aligned with the FDA’s Opioids Action Plan and has been engineered to make fentanyl patches safer without restricting access for legitimate patients. The product may also benefit from regulatory pressure to shift all fentanyl patch formulations toward abuse-deterrent formats, similar to previous changes required for oxycontin generics. Nutriband’s AVERSA platform is protected by a broad international IP portfolio with patents issued in 46 countries. Most recently, the company was granted a US patent for its transdermal abuse-deterrent system in June 2025, further strengthening its competitive moat. Nutriband’s inclusion in the Russell Microcap, Russell Microcap Growth, Russell 3000E, and Russell 3000E Growth indexes signals growing institutional awareness. Management believes this milestone reflects accelerating progress toward building shareholder value and positioning AVERSA Fentanyl as a potential category leader in opioid safety. With real revenue, a large addressable market, strong IP, and a progressing regulatory timeline, Nutriband Inc. offers investors early exposure to a unique solution in the fight against opioid abuse. Collegium Pharmaceutical, Inc. (Nasdaq: COLL) is quietly becoming a standout in the pain and neuropsychiatry treatment markets, driven by consistent revenue growth, expanding product reach, and shareholder-focused capital allocation. In the first quarter of 2025, Collegium reported net revenue of 177.8 million dollars, up 23 percent year-over-year, with its ADHD medication Jornay PM growing prescriptions by 24 percent and generating 28.5 million dollars in revenue for the quarter. The company has now completed a major field force expansion, bringing its ADHD sales team to approximately 180 representatives to support continued growth in this space. The company’s core pain portfolio also continues to deliver. In Q1 2025, Collegium generated 149.2 million dollars in revenue from its chronic pain medications, with each of its flagship products—Belbuca, Xtampza ER, and the Nucynta franchise—posting year-over-year growth. Belbuca alone brought in 51.7 million dollars, up 2 percent, while Xtampza ER and Nucynta added 47.6 million and 47.1 million, respectively. Collegium’s strong financial performance has supported aggressive yet balanced capital deployment. In May, the company announced a 25 million dollar accelerated share repurchase, part of a broader 150 million dollar program, reflecting confidence in its long-term value. The company ended Q1 with 197.8 million dollars in cash, up from 162.8 million at year-end 2024, and generated over 55 million dollars in cash from operations. With reaffirmed full-year guidance, expanding leadership, and strong product execution, Collegium is establishing itself as a consistent revenue generator in the biopharma space. Its dual focus on responsibly managed pain treatments and a fast-growing ADHD franchise gives it a diversified growth engine in two high-need therapeutic areas. For investors seeking a profitable, commercial-stage biotech with upside potential and disciplined management, Collegium deserves a closer look. Assertio Holdings, Inc. (Nasdaq: ASRT) is a specialty pharmaceutical company in transition, executing a focused strategy to strengthen its commercial platform while shedding legacy risks. In the first quarter of 2025, the company reported 26 million dollars in total net product sales, tracking in line with its full-year guidance. Management emphasized that sales from its growth assets, particularly Rolvedon and Sympazan, are outperforming internal expectations, providing a strong foundation for Assertio’s near-term revenue expansion. Assertio is actively streamlining operations and reducing legal exposure, having settled multiple longstanding lawsuits, including the DOJ False Claims Act case and opioid-related liabilities. A major structural move was the divestiture of Assertio Therapeutics, which held legacy legal obligations and low-value assets. That transaction has now fully removed Assertio Holdings and its current subsidiaries from all opioid litigation. This cleanup effort allows management to focus entirely on high-potential assets and business development. Rolvedon, a treatment for chemotherapy-induced neutropenia, continues to show momentum, with Q1 sales outperforming despite prior-quarter inventory stocking. Management expects steady growth for the product throughout 2025. Sympazan, a prescription oral film for Lennox-Gastaut syndrome, also benefited from a revised promotional strategy, driving a 6.5 percent year-over-year increase in prescriptions during the quarter. With a cleaned-up balance sheet, narrowed commercial focus, and a disciplined approach to portfolio expansion, Assertio is entering a new phase. The company aims to become a preferred partner in specialty pharma, leveraging its commercial infrastructure to onboard new products across therapeutic areas. For investors seeking a turnaround story with defined growth levers and reduced legal overhang, Assertio may be one to watch in 2025. Aquestive Therapeutics, Inc. (Nasdaq: AQST) is a pharmaceutical company focused on advancing medicines that improve patients’ lives through innovative science and delivery technologies. The company develops orally administered products to deliver complex molecules, offering novel alternatives to invasive standard therapies. Aquestive currently has four licensed commercial products marketed globally and serves as the exclusive manufacturer for these products. It also collaborates with pharmaceutical partners using proprietary technologies like PharmFilm and has established drug development and commercialization capabilities. The company is progressing a late-stage proprietary candidate, Anaphylm™, an oral sublingual film for severe allergic reactions including anaphylaxis, alongside an early-stage epinephrine prodrug topical gel, AQST-108, targeting dermatological conditions such as alopecia areata. In Q1 2025, Aquestive submitted its NDA for Anaphylm and is preparing for a potential U.S. launch in early 2026, pending FDA approval. The NDA includes comprehensive adult and pediatric clinical data demonstrating a pharmacokinetic profile consistent with existing epinephrine autoinjectors. Aquestive has expanded its market access and medical affairs teams and is advancing commercial readiness, including plans for regulatory submissions in key international markets. The FDA assigned a PDUFA target action date of January 31, 2026, and may convene an Advisory Committee meeting during the review process. Sales of royalty-based products such as Sympazan® and Azstarys® contributed to revenue during the quarter, while manufacturing revenue declined due to lower Suboxone® volumes but was partially offset by growth in other collaborations. Total revenue for Q1 2025 was $8.7 million, down 28% from $12.1 million in Q1 2024. Research and development expenses decreased slightly, while selling, general, and administrative expenses rose primarily due to regulatory and commercial investments linked to Anaphylm’s launch preparations. Aquestive reported a net loss of $22.9 million for the quarter and held $68.7 million in cash at March 31, 2025. The company has paused sales and marketing activities for Libervant® following a court decision affecting its approval status, with plans to resume patient access in 2027 or sooner if permitted. Aquestive revised its 2025 revenue guidance to $44 to $50 million and non-GAAP adjusted EBITDA loss guidance to $47 to $51 million, reflecting the impact of this change. With its innovative, non-invasive epinephrine treatment nearing regulatory approval, broad IP protection, and a clear commercial strategy, Aquestive is positioned to offer a meaningful new option for patients with severe allergic reactions and to expand its footprint in specialty pharmaceutical delivery. Disclaimers: RazorPitch Inc. "RazorPitch" is not operated by a licensed broker, a dealer, or a registered investment adviser. This content is for informational purposes only and is not intended to be investment advice. The Private Securities Litigation Reform Act of 1995 provides investors a safe harbor in regard to forward-looking statements. Any statements that express or involve discussions with respect to predictions, expectations, beliefs, plans, projections, objectives, goals, assumptions, or future events or performances are not statements of historical fact and may be forward-looking statements. Forward-looking statements are based on expectations, estimates, and projections at the time the statements are made that involve a number of risks and uncertainties that could cause actual results or events to differ materially from those presently anticipated. Forward-looking statements in this action may be identified through the use of words such as projects, foresee, expects, will, anticipates, estimates, believes, understands, or that by statements indicating certain actions & quote; may, could, or might occur. Understand there is no guarantee past performance will be indicative of future results. Investing in micro-cap and growth securities is highly speculative and carries an extremely high degree of risk. It is possible that an investor's investment may be lost or impaired due to the speculative nature of the companies profiled. RazorPitch has been retained and compensated by Awareness Consulting LLC to assist in the production and distribution of this content. RazorPitch is responsible for the production and distribution of this content. It should be expressly understood that under no circumstances does any information published herein represent a recommendation to buy or sell a security. This content is for informational purposes only; you should not construe any such information or other material as legal, tax, investment, financial, or other advice. Nothing contained in this article constitutes a solicitation, recommendation, endorsement, or offer by RazorPitch or any third-party service provider to buy or sell any securities or other financial instruments. All content in this article is information of a general nature and does not address the circumstances of any particular individual or entity. Nothing in this article constitutes professional and/or financial advice, nor does any information in the article constitute a comprehensive or complete statement of the matters discussed or the law relating thereto. RazorPitch is not a fiduciary by virtue of any persons use of or access to this content. Contact Details RazorPitch Mark McKelvie +1 585-301-7700 mark@razorpitch.com Company Website http://razorpitch.com

July 02, 2025 06:00 AM Eastern Daylight Time

News Release

Wall Street Analyst Issues Bullish Update on DarioHealth, Reiterates $3 Price Target Highlighting 320% Upside Potential (NASDAQ: DRIO)

Alpha Catalyst

Wall Street analyst Theodore O'Neill of Litchfield Hills Research has reiterated his Buy rating and $3 price target on DarioHealth Corp. (NASDAQ: DRIO)*, highlighting what he sees as significant upside potential of approximately 320% from current trading levels around $0.71. The analyst's updated note comes as recently IPO’d competitor Hinge Health (NYSE: HNGE) currently trades at a $3.53 billion market cap following its successful public debut, creating what O'Neill describes as a stark "valuation gap" with DarioHealth, which has a market capitalization of approximately $31 million despite comparable growth metrics and superior gross margins. GLP-1 Success Validates Platform's Value Proposition The research update particularly emphasized DarioHealth's recent clinical findings presented at the American Diabetes Association's 85th Annual Scientific Sessions. A landmark study of 715 GLP-1 users revealed that patients who discontinued their medication maintained stable outcomes with no significant weight or glucose rebound for at least six months when using Dario's platform. The analyst's report highlights DarioHealth's study findings that demonstrated users who discontinued GLP-1 medication while continuing to use the platform maintained stable outcomes without significant weight or glucose rebound for at least six months. O'Neill points to these clinical results as a key differentiator for the company's value proposition in the expanding GLP-1 market. This clinical validation comes at a critical time as the GLP-1 market for weight loss medications is projected to reach $100 billion by 2030, with employers increasingly struggling to manage the high costs of these drugs while ensuring sustainable patient outcomes. Strategic Partnerships Expand Addressable Market The analyst also highlighted DarioHealth's recent strategic commercial agreement with GreenKey Health announced on June 26, which targets the $150 billion sleep apnea market affecting over 29 million Americans. The collaboration integrates behavioral health, sleep, and cardiometabolic care to deliver a comprehensive solution for employers and health plans seeking to reduce healthcare costs. O'Neill's analysis emphasizes the strategic benefits of DarioHealth's partnership with GreenKey Health, noting how the collaboration combines their respective strengths to create a comprehensive, data-driven solution designed to improve health outcomes, reduce costs, and boost productivity for employers and health plans. Dramatic Valuation Discount Compared to Peers The most compelling aspect of the analyst's thesis is the dramatic valuation contrast between DarioHealth and its peers. Using a discounted future earnings model and comparative peer analysis, O'Neill calculates a fair value of $3 per share. According to the report, If DarioHealth were to trade at this target, its Market Cap/Sales multiple would be approximately 2.2x, which would still be below the peer average of 2.38x, according to the analyst's calculations. This suggests the company remains significantly undervalued even at the target price, especially considering its high growth profile and improving gross margins. The company's B2B2C gross margins now exceed 80%, higher than many competitors, while operating expenses have declined significantly, positioning the company on a path to operational cash flow breakeven by the end of 2025. Financial Outlook Supports Bullish Thesis O'Neill forecasts DarioHealth could reach $35.9 million in revenue for 2025, growing to $66.1 million in 2026, with the company expected to achieve GAAP profitability during 2026. DarioHealth's AI-driven platform serves five chronic conditions through a single interface, diabetes, hypertension, weight management, musculoskeletal pain, and behavioral health, giving it one of the most comprehensive offerings in the industry and positioning it to capitalize on employer and payer trends toward vendor consolidation. As digital health platforms continue to gain traction and the GLP-1 market expands, O'Neill believes DarioHealth remains positioned for potential significant share price appreciation as the market recognizes its comparable business metrics relative to recently validated competitors. ‎ ‎ ‎ This post was originally published on AlphaCatalyst ‎ ‎ Recent News Highlights from Dario Dario and GreenKey Health Announce Strategic Commercial Agreement to Transform Chronic Condition Management and Sleep Health for Payers Nationwide Dario Unveils Groundbreaking GLP-1 and AI-Personalization Digital Health Findings DarioHealth Reports First Quarter 2025 Financial and Operating Results ‎ ‎ ‎ * Paid Advertisement: This content is a paid advertisement. The Author, Wall Street Wire, has received compensation from DarioHealth Corp for promotional media services provided on an ongoing subscription basis. This content is for informational purposes only and does not constitute financial advice. Wall Street Wire is not a broker-dealer or investment adviser. Full compensation details and information regarding the operator of Wall Street Wire are available redditwire.com/terms. We are not responsible for any price targets or market size estimates that may be cited in this article nor do we endorse them, they are quoted based on publicly available news reports and additional price targets may exist that may not have been quoted. Readers are advised to refer to the full reports mentioned on various systems and the disclaimers/disclosures they may be subject to. Contact Details ‎ media.globalmarkets@gmail.com

July 02, 2025 05:46 AM Eastern Daylight Time

News Release

Dr Nazmi Baycin Dubai Emerges as a Global Leader in Aesthetic Medicine Led by Renowned Plastic Surgeon

Rev Up Marketers

Dubai is rapidly solidifying its position as a global capital for aesthetic medicine, with the city’s thriving plastic surgery sector contributing significantly to both healthcare growth and economic diversification. Central to this rise is Dr. Nazmi Baycin, a leading plastic surgeon with over 25 years of experience and a decade of distinguished practice in Dubai. Recent data shows that Dubai conducted over 50,000 aesthetic procedures in 2023, generating an estimated $2.5 billion in market value. With a projected annual growth rate of 7–10%, the emirate is quickly becoming one of the world’s most sought-after destinations for cosmetic and elective medical tourism. Dr. Baycin is recognized for his expertise in procedures such as breast augmentation, female genital surgery, tummy tucks, and chin reshaping. His patient-centered approach, paired with advanced technologies and an artistic eye, has set new benchmarks in aesthetic surgery standards across the region. “Dubai offers an unparalleled combination of clinical excellence, privacy, and cultural accessibility,” said Dr. Baycin. “These qualities continue to attract a growing number of patients, particularly from the Gulf Cooperation Council (GCC) region.” A recent report According to the Dubai Health Authority, more than 691,000 medical tourists visited the emirate in 2023, with nearly half arriving specifically for cosmetic treatments. This influx contributed around AED 1 billion ($280 million) directly to the healthcare sector, and an estimated AED 2.3 billion in indirect revenue across hospitality, real estate, transportation, and wellness services. Dubai’s emergence as a plastic surgery hub is supported by strategic initiatives such as the Dubai Economic Agenda (D33), which aims to double the city’s GDP and enhance its reputation as a global innovation and investment hub. Medical tourism plays a central role in this strategy, with plastic surgery leading the charge. The city’s specialized medical zones—such as Dubai Healthcare City —offer cutting-edge infrastructure, favorable tax conditions, and strong regulatory frameworks, attracting both top-tier talent and international patients. The integration of AI diagnostics, robotic-assisted surgeries, and 3D imaging technology ensures precision, safety, and minimal downtime for patients. Social media has also played a pivotal role in shaping regional aesthetic preferences. Dr. Baycin notes a significant increase in demand for natural-looking, minimally invasive enhancements, particularly among patients from Saudi Arabia, Kuwait, and across the Gulf. “As cultural norms evolve and beauty standards become more globally influenced, personalized aesthetic procedures are gaining popularity,” added Dr. Baycin. “Dubai is meeting that demand with world-class solutions.” With robust government support, advanced medical infrastructure, and a growing influx of high-net-worth individuals seeking discreet care, Dubai is on track to become the global epicenter of aesthetic medicine in the coming decade. About Nazmi Baycin Clinic Nazmi Baycin Clinic is a premier aesthetic surgery practice based in Dubai, led by internationally acclaimed plastic surgeon Dr. Nazmi Baycin. With over 25 years of global surgical experience and more than a decade serving clients in the UAE, the clinic is renowned for delivering advanced, patient-focused cosmetic procedures. Specializing in breast augmentation, female genital surgery, tummy tucks, and facial enhancements, Dr. Baycin combines medical precision with artistic sensibility to provide natural, personalized results. Situated in the heart of Dubai’s medical district, the clinic caters to a diverse international clientele, offering world-class care, discretion, and cutting-edge surgical technologies. For more information, visit www.nazmibaycin.com. Contact Details Nazmi Baycin Dr. Nazmi Baycin info@nazmibaycin.com Company Website https://www.nazmibaycin.com

July 01, 2025 05:30 PM Eastern Daylight Time

ALLIES OF SKIN PARTNERS WITH MINDFULNESS EXPERT AND BEST-SELLING AUTHOR CASE KENNY FOR “SKINCARE = SELF-CARE” CAMPAIGN

Allies of Skin

Allies of Skin, the supercharged clinical skincare brand founded by Nicolas Travis, announces its partnership with mindfulness expert and best-selling author Case Kenny to celebrate the connection between skincare and self-care. Renowned for its results-driven routines, personally curated by Nicolas Travis from the brand’s assortment of supercharged clinical skincare, Allies of Skin is taking skincare one step further. Together with Case Kenny, they introduce a powerful perspective: skincare as self-affirmation. Allies of Skin's iconic routines are sealed with a bespoke affirmation created by Case Kenny – restoring the skin while reconnecting you with your sense of self. The collaboration invites consumers to turn their daily regimens into powerful acts of self-connection, blending high-performance formulas with holistic wellness. Affirmations aren’t just an add-on – they're the final, essential step in any skincare routine. Just as an Allies of Skin product seals in skincare benefits, a self-affirmation seals in intention. Great skin has the power to make you feel better – more confident, more centered, and more connected to yourself. Together, Nicolas Travis and Case Kenny are lighting both the inner and outer light for consumers, redefining skincare as a ritual for total well-being. For the collaboration and as an official #ALLIESPartner, Case Kenny will curate bespoke digital affirmation cards which will be available through social “drops,” lead engaging social content centered around mindfulness, skincare, and self-love, host events aimed at building conscious community, and participate in a co-branded influencer seeding to spread the message that skincare equals self-care. FROM THE FOUNDER "It has taken 18 years for me to appreciate the beauty of the scars from my experience with facial necrosis. Through my own healing journey, I discovered Case Kenny and his brilliant work. His words resonate with me on a soul level, and they serve as guiding light on dark days. It is this light that I hope to share with our allies. The unwavering light that comes with being at home in your skin. The light that radiates from within when you are at peace with yourself and your journey. The light that no person or situation can diminish. It’s time for all of us to shine a little brighter," says Nicolas Travis, Founder of Allies of Skin. FROM CASE KENNY "I’m very excited to partner with Allies of Skin because we share the same belief: the light you carry comes from what you’ve healed. I believe the darkness you endure in life only makes your light shine brighter, and Allies of Skin believes the same. They believe that skincare isn’t just about how you look, but how you feel. That how you care for yourself on the outside is a reflection of the self-respect, growth, and peace you’re building within. That your outer glow is a mirror of your inner work. What I love most is their mission to make skincare more human - to honor the ups and downs, to embrace the imperfections, and to remind us that showing up for yourself is enough. That kind of alignment is meaningful," says Case Kenny. To stay updated on drops, events, and inspiration, follow @alliesofskin and @casekenny on Instagram. ABOUT ALLIES OF SKIN Allies of Skin redefines skincare with a “supercharged clinical” approach, maximizing clinically proven actives, protective antioxidants, and supporting the skin barrier. Founded by Nicolas Travis in 2016, the high-performance formulas deliver visible, transformative results in fewer steps, with innovative active ingredients like Epidermal Growth Factors (GF), Copper Tripeptide, and patented Encapsulated Retinaldehyde (Retinal), with the mission of delivering unparalleled skin regeneration and longevity. Contact Details OGAKI Digital Hallie Sawyer +1 818-388-7338 hsawyer@ogakidigital.com Company Website https://us.allies.shop/

July 01, 2025 05:24 PM Eastern Daylight Time

Former Oura CEO, Harpreet Singh Rai, Joins Loop to Accelerate Preventive Health Innovation

Loop

Loop, the insurance and healthcare company on a mission to add 20 healthy years to the lives of working Indians, has announced that Harpreet Singh Rai, former CEO of health-tracking pioneer Oura and an early investor in Loop, has joined Loop as President, Healthcare. Harpreet brings a decade of experience in building and scaling preventive health solutions that merge science, data, and human behavior. As CEO of Oura from 2018 to 2021, he led the launch of the company’s 2nd and 3rd generation rings, selling over 1 million units. In his new role, Harpreet will lead the development of Loop’s healthcare products, working closely with Loop’s medical, product, and engineering teams. His focus will be on creating seamless, engaging experiences that help people take charge of their health. “India's workforce loses 20 years compared to global peers; not because of destiny, but because our system profits from sickness rather than health. Harpreet has built consumer health products that people actually use and love. That's exactly the leadership we need to scale prevention beyond corporate walls,” said Mayank Kale, Co-founder and CEO at Loop. Before Oura, Harpreet spent nine years as a technology portfolio manager at Eminence Capital, focusing on healthcare and technology investments. He began his career in Morgan Stanley’s M&A group and holds a degree in electrical engineering from the University of Michigan. His rare blend of engineering, investing, and health leadership uniquely equips him to accelerate Loop’s prevention-first approach. “Loop is building something fundamentally different—Mayank and the team have a unique lens to improve healthcare for India. I’m excited to help make healthcare more accessible, engaging, and measurable for millions of working Indians. This is how we add decades to lives—one person, one family, one company at a time,” said Harpreet Singh Rai. About Loop Loop is on a mission to add 20 healthy years to the Indian workforce. By combining best-in-class insurance with unlimited primary care and data-led prevention, Loop empowers over 850,000 employees at 1,200+ companies to live longer, healthier lives. Backed by global investors including Y Combinator, Khosla Ventures, Elevation Capital, and General Catalyst, Loop is redefining corporate healthcare by making prevention profitable, outcomes measurable, and vibrant health possible for every team in India. Contact Details Aditya +91 88607 36808 Aditya.dwivedi09@gmail.com Company Website https://www.loophealth.com/

June 27, 2025 10:00 AM Eastern Daylight Time

Back to the Doctor’s Office: As Telehealth Declines, Demand for In-Person Care Drives a Medical Real Estate Shift

The Hoyt Organization

In the wake of the COVID-19 pandemic, virtual healthcare saw a historic surge. But now, a new trend is emerging: patients are returning to their doctors' offices — and they’re doing it in droves. According to new data from the Center for Telehealth and e-Health Law (CTeL), telehealth use has entered a steady decline since its peak during the pandemic. With the expiration of emergency policies that once expanded access to virtual care, analysts project a staggering 12 million telehealth appointments will be lost annually. This shift is placing renewed importance on brick-and-mortar medical practices—and driving an urgent need for physical medical office space in urban hubs across the country. “This isn’t just a statistical dip — it’s a fundamental shift,” says Kurt Hackett, Vice President of Asset Management at Rethink Capital, which owns and manages the Medical Pavilion at 939 Ellis Street in San Francisco. “We're seeing patients of all types of medical disciplines re-emphasize the value of in-person care, and providers are responding by ramping up their physical presence.” A Premier Option in San Francisco's Healthcare Corridor At the heart of the resurgence of in-person care is the Medical Pavilion at 939 Ellis Street, a premier medical office building situated in San Francisco’s vibrant healthcare corridor along Van Ness Avenue. Nestled close by Sutter Health’s CPMC Van Ness Campus, the Pavilion offers a strategic, central location for healthcare providers looking to expand or relocate to a high-demand urban market. “939 Ellis Street is perfectly positioned for providers who need immediate access to hospital systems, public transit, and city and suburban population,” says Hackett. “It checks all the boxes for modern medical delivery.” The property features: Proximity to top-tier health systems and medical campuses Full and partial floor suites to accommodate a wide range of medical uses Infrastructure designed to meet today’s clinical and compliance needs On-site parking, and mass transit accessibility What’s Driving the In-Person Comeback? Several factors are contributing to the retreat from telehealth and the renewed interest in physical appointments: Clinical Limitations of Virtual Care: While video consultations offer convenience, many conditions — such as orthopedic and cardiac issues, cancer care, and urological disorders — require physical examinations, lab work, and imaging that simply cannot be done remotely. Insurance Reimbursement Reversions: As emergency-era policies sunset, insurers are reverting to pre-COVID reimbursement models which often favor in-person visits. This reimbursement structure creates an incentive for providers to bring patients back into the office. Digital Fatigue: After years of Zoom meetings, online learning, and virtual appointments, both patients and providers are reporting burnout with screen-based interactions. Trust and Patient Experience: Research continues to show that face-to-face care fosters stronger patient-provider relationships and improves long-term treatment outcomes—something digital platforms have struggled to replicate. Investment Strategies Follow the Trend For real estate investors and healthcare providers alike, the shift back to in-person care is shaping portfolio decisions in key metro markets like San Francisco, where aging medical stock and strong population density make modern medical offices particularly attractive. “Providers are increasingly seeking newer, well-located facilities that reflect the current standards of care,” Hackett explains. “Our goal at the Medical Pavilion is to offer not just square footage, but an ecosystem where quality care can thrive.” A New Era of Care Delivery As the pendulum swings away from virtual-first healthcare, the demand for high-quality, strategically located medical office space is expected to grow — particularly in regions like the Bay Area, where healthcare innovation and patient demand continue to intersect. For providers seeking to adapt and grow in this changing environment, properties like the Medical Pavilion at 939 Ellis Street represent a unique opportunity: the chance to be part of San Francisco’s healthcare future, right in the heart of its medical corridor. For leasing inquiries at 939 Ellis St., contact Trask Leonard, president and CEO of Bayside Realty Partners at tleonard@baysiderp.com. About Medical Pavilion at 939 Ellis Street: Positioned in the Van Ness medical hub, Medical Pavilion at 939 Ellis Street is a purpose-built medical office building offering flexible, large-scale space options for healthcare users, with direct access to public transit, nearby hospitals, and the city’s primary healthcare corridor. It can accommodate a range of specialties. It boasts a scenic rooftop terrace and available parking. Contact Details Leeza Hoyt +1 310-343-3197 llhoyt@hoytorg.com Company Website https://939-ellis.com/

June 26, 2025 08:00 AM Pacific Daylight Time

NeuroSense Inches Closer to Pharma Partnership as Canadian Regulatory Progress Turns Heads

The Finance Herald

NeuroSense Therapeutics (NASDAQ: NRSN)* has completed a key pre-submission meeting with Health Canada for its ALS drug PrimeC, signaling potential upcoming eligibility for Canada’s fast-track approval pathway (NOC/c). The positive tone reported from the meeting could signal accelerated Canadian approval coming soon and could also potentially advance negotiations for the partnership with a global pharma player. With strong Phase 2b data and a potential $100–150M of peak revenue from Canadian market alone, this milestone could be a catalyst for regulatory momentum and investor revaluation. ‎ NeuroSense Therapeutics (NASDAQ: NRSN) may be nearing a turning point in its ALS drug development journey, and the market is starting to take notice. The Israeli biotech just disclosed that it held a pivotal pre-submission meeting with Health Canada for PrimeC, its lead ALS candidate, potentially setting the stage for both early approval and the finalization of a major pharma partnership. In a Form 6-K filed with the SEC, NeuroSense confirmed the completion of a pre-New Drug Submission (pre-NDS) meeting with regulators to explore eligibility for Canada’s fast-track approval mechanism, known as the Notice of Compliance with Conditions (NOC/c). The company described the discussion as “constructive” and left the meeting “highly encouraged”, language that signals regulatory alignment and opens the door for PrimeC to potentially Canadian patients much sooner than expected. For ALS patients in Canada—and a company with a current ~$52 million valuationm that kind of timeline could prove transformational. But the Health Canada development is more than just a regulatory checkpoint—it’s a potential trigger for something bigger. Back in December 2024, NeuroSense signed a binding term sheet with a global pharmaceutical company, covering full Phase 3 funding, upfront cash, milestone payments, and double-digit royalties. A positive signal from Canadian authorities could be the validation needed to cement that deal and set the stage for global expansion. PrimeC already has data to back up its ambitions. In its Phase 2b PARADIGM trial, the therapy showed a 36% slowdown in ALS progression and a 43% improvement in survival compelling outcomes in a field where treatment options are few and efficacy gains are hard-won. That performance is part of what’s drawing interest from the industry—and why a Canadian approval could serve as a powerful launchpad, both commercially and strategically. The Canadian ALS market alone could support $100–150 million in annual peak sales, according to company estimates. But what’s arguably more valuable is the opportunity to generate real-world data and establish market traction ahead of broader approvals, particularly in the U.S. and Europe. Investors likely won’t have to wait long for clarity. NeuroSense expects to receive official meeting minutes from Health Canada shortly and will update the market once eligibility is confirmed. If successful, the NDS filing and Phase 3 launch would likely follow. In a sector defined by long timelines and uncertain outcomes, NeuroSense now finds itself in a rare position, with validated clinical data, regulatory momentum, and a pending global partnership that could reprice the story entirely. The next few months may determine whether PrimeC becomes not only a commercial product, but also a cornerstone of a much larger biotech success. ‎ Read more from the Finance Herald The New Digital Iron Curtain: How the EU’s Digital Services Act Threatens American Free Speech The Nobel Dilemma: Should Trump Embrace or Reject a Controversial Legacy? New York City’s Political Revolution: Zohran Mamdani’s Far-Left Vision Sparks National Debate States Challenge Trump Administration’s Funding Cuts in Major Legal Battle Heating Up: Power Crisis Strikes the Eastern U.S. Amid Record Temperatures ‎ ‎ * ⚠︎ Paid Advertisement: This content is a paid advertisement. Wall Street Wire has received compensation from NeuroSense Therapeutics Ltd. for promotional media services provided on an ongoing subscription basis. This content is for informational purposes only and does not constitute financial advice. Wall Street Wire is not a broker-dealer or investment adviser. Full compensation details and information regarding the operator of Wall Street Wire are available redditwire.com/terms. We are not responsible for any price targets that may be cited in this article nor do we endorse them, they are quoted based on publicly available news reports and additional price targets may exist that may not have been quoted. Readers are advised to refer to the full reports mentioned on various systems and the disclaimers/disclosures they may be subject to. Contact Details ‎ media.globalmarkets@gmail.com

June 26, 2025 09:24 AM Eastern Daylight Time

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This $13M Biotech Has $40M in Pentagon Funding – Here’s Why BiomX Could Be Biotech’s Best-Kept Secret

VentureBlock

With 3X Its Market Cap in Military Grants and Analyst Targets of $15-16, This Military-Backed Phage Therapy Pioneer Trades at Just $0.48 (NYSE: PHGE)*, all while their competitor (NYSE: ARMP) trades at over 6X ‎‎ BiomX Inc. (NYSE: PHGE)* presents an unusual situation in biotech: a company trading at just below a $13 million market cap that has secured $40 million in non-dilutive funding from the U.S. Defense Health Agency. This Pentagon backing, administered through the Naval Medical Research Command, has enabled the company to advance its bacteriophage therapies without the typical shareholder dilution that plagues early-stage biotechs. The military’s interest centers on antibiotic-resistant infections emerging from conflict zones. According to BiomX CEO Jonathan Solomon, medical personnel are “seeing soldiers coming out of the Ukraine war with extremely antibiotic-resistant infections.” This real-world crisis has elevated phage therapy, using viruses that naturally kill bacteria, from scientific curiosity to strategic priority. ‎ The Numbers Behind the Story BiomX’s recent Phase 2 DANCE trial results help explain the military’s confidence. The study of 41 patients with diabetic foot osteomyelitis showed: Statistically significant reduction in ulcer size by week 12 (p=0.046) Greater than 40% difference in healing between treatment and placebo groups by week 10 Significant improvement in ulcer depth at week 13 (p=0.048) Significant reduction in ulcer area expansion (p=0.017) No serious adverse events These results matter because diabetic foot infections lead to approximately 160,000 amputations annually in the U.S., creating an $8 billion healthcare burden. The same Staphylococcus aureus bacteria causing these civilian amputations also complicates combat wound care, making BX211 a dual-use technology. ‎ Beyond Military Applications While defense funding validates the technology, BiomX’s commercial opportunity spans multiple indications. The company’s BX004 program for cystic fibrosis demonstrated that 14.3% of patients (3 out of 21) completely cleared chronic Pseudomonas aeruginosa lung infections after 10 days of treatment, compared to 0% in the placebo group. One patient had carried the infection for 35 years before achieving clearance. BiomX estimates addressable markets of $2.5 billion globally for diabetic foot infections and $1.6 billion for cystic fibrosis. The FDA has already granted Fast Track and Orphan Drug designations to BX004, potentially accelerating the regulatory pathway. ‎ The Market Disconnect & Opportunity Current analyst coverage reveals a striking valuation gap. H.C. Wainwright maintains a Buy rating with a $15 price target, while Laidlaw & Company also rates the stock Buy with a $16 target. From recent trading levels around $0.52, these targets represent potential upside of approximately 2,800-2,900%. Laidlaw analyst Yale Jen called the BX211 Phase 2 results “an absolutely positive surprise,” characterizing the asset as “high value and clinically de-risked.” H.C. Wainwright’s assessment emphasizes the program’s advancement toward “important regulatory discussions” with the FDA. The disconnect becomes even more apparent when compared to peers. Armata Pharmaceuticals (NYSE: ARMP), the only other publicly-traded pure-play phage therapy company, trades at approximately $70 million, more than 5X BiomX’s valuation despite having just one clinical program compared to BiomX’s two Phase 2 assets and $40 million in military backing. ‎ Understanding the Opportunity Several factors contribute to BiomX's current valuation disconnect: Non-dilutive funding advantage: The $40 million military grant has funded clinical development without issuing new shares, preserving value for existing shareholders. Limited competition: No new drugs have been approved specifically for diabetic foot osteomyelitis in over 20 years, giving BiomX potential first-mover advantage in a massive unmet need. Impressive platform validation: Success in two separate indications (DFO and cystic fibrosis) demonstrates the broader applicability of the phage platform. Near-term catalysts: Phase 2b results for BX004 expected in Q1 2026, FDA meetings for BX211 Phase 2/3 design, and potential additional military funding or partnerships. ‎ The Broader Context BiomX operates within converging megatrends. The Biden administration has proposed $88.2 billion for biodefense over five years, while organizations like DARPA and ARPA-H are investing hundreds of millions in next-generation antimicrobials. NATO has formed a task force specifically to reintroduce phage therapy in military medicine. The company’s ability to address both military and civilian needs positions it uniquely as governments worldwide recognize antimicrobial resistance as a national security threat. With China producing 80-90% of antibiotic raw materials, supply chain vulnerabilities add urgency to developing alternative therapies. ‎ Looking Ahead BiomX’s story combines validated science, government backing, and massive market opportunities with a market cap that appears disconnected from fundamental value. The $40 million in Pentagon funding alone exceeds the company’s current market valuation by 3X, while clinical success and analyst targets suggest significant upside potential. As the company advances toward Phase 2/3 trials for BX211 and awaits Phase 2b results for BX004, the convergence of military necessity and civilian healthcare needs could transform this overlooked biotech into a key player in humanity’s fight against antibiotic-resistant infections. ‎ This article was syndicated from VentureBlock. ‎ ‎ Recent News Highlights BiomX: BiomX CEO Jonathan Solomon to Present at Biomed Israel 2025 Conference BiomX Reports First Quarter 2025 Financial Results and Provides Business and Program Updates BiomX to Host First Quarter 2025 Financial Results Conference Call and Webcast on May 15, 2025 BiomX Announces Compliance with NYSE Guidelines on Audit Opinion Disclosure BiomX Announces Positive Topline Results from Phase 2 Trial Evaluating BX211 for the Treatment of Diabetic Foot Osteomyelitis (DFO) ‎ ‎ * ⚠︎ Paid Advertisement Disclaimer: This content is a paid advertisement. Wall Street Wire has received compensation from BiomX Inc. for promotional media services provided on an ongoing subscription basis. This content is for informational purposes only and does not constitute financial advice. Wall Street Wire is not a broker-dealer or investment adviser. Full compensation details and information regarding the operator of Wall Street Wire are available redditwire.com/terms. We are not responsible for any price targets that may be cited in this article nor do we endorse them, they are quoted based on publicly available news reports and additional price targets may exist that may not have been quoted. Readers are advised to refer to the full reports mentioned on various systems and the disclaimers/disclosures they may be subject to. Contact Details ‎ media.globalmarkets@gmail.com

June 26, 2025 08:31 AM Eastern Daylight Time

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News Release

NOA Lithium Strikes Critical Water: A Game-Changing Discovery for Rio Grande Project

Global Markets News

In the parched landscapes of Argentina's Lithium Triangle, water is as valuable as the lithium itself. NOA Lithium Brines Inc. (TSXV: NOAL) (OTCPK: NLIBF) has just announced a discovery that could dramatically accelerate the development timeline of its flagship Rio Grande Project—fresh water. The company revealed today that it has successfully located an on-site fresh water source within its 100%-owned Rio Grande Project boundaries, marking a pivotal milestone in the project's advancement toward production. Why This Water Discovery Matters For lithium brine projects, access to industrial water is a make-or-break factor. In the arid regions where lithium salars are typically found, securing water rights and sources can be challenging, expensive, and time-consuming. By discovering this resource on its own property, NOA has eliminated a significant hurdle in the development pathway. "This marks another significant milestone in the advancement of the Rio Grande Project," stated Gabriel Rubacha, NOA's Chief Executive Officer. "Not only have we discovered a fresh water source on-site and within our properties, but its location aligns perfectly with the area of highest lithium concentration and our preliminary assessment for locating a production facility and evaporation ponds." The strategic positioning of this water well, drilled to a depth of 190 meters in the northern section of the project, couldn't be more advantageous. It's situated close to the areas where NOA has identified the highest concentration of lithium and porosity to date—precisely where the company envisions developing future production facilities and evaporation ponds. A Series of Strategic Wins This water discovery adds to NOA's impressive streak of achievements over the past year. The company has methodically checked off critical boxes in its development roadmap: The water well represents one of three fresh water targets identified at Rio Grande, suggesting further potential for expanded water resources as development continues. Positioned in the Heart of the Lithium Triangle NOA's strategic position in Argentina's Lithium Triangle gives it proximity to some of the world's highest-grade, lowest-cost lithium operations. The company has assembled one of the largest lithium brine claim portfolios in the region not owned by a producing company, with over 140,000 hectares across three prospective salars: Rio Grande, Arizaro, and Salinas Grandes. This vast land package in Salta Province—widely recognized as one of Argentina's most mining-friendly jurisdictions—positions NOA alongside industry leaders like Arcadium, Lithium Argentina, Ganfeng, and Rio Tinto. Looking Forward: Accelerating Development With the PEA expected in Q3 2025, NOA is rapidly advancing toward a comprehensive economic evaluation of the Rio Grande Project. The current design contemplates an initial production capacity of approximately 20,000 metric tonnes per year of lithium carbonate equivalent, with scalability to double that capacity through modular expansion. The water discovery adds tangible value to this economic assessment by potentially reducing both capital and operating costs associated with water procurement and transport. As global lithium demand continues to surge, driven by electric vehicle adoption and energy storage requirements, NOA's steady advancement of its Rio Grande Project positions it as an emerging player in the lithium supply chain at precisely the right time. For investors watching the lithium space, NOA's methodical derisking of its flagship project and continued achievement of development milestones make it a compelling story to follow as it progresses toward its goal of becoming Argentina's next major lithium producer. ‎ Recent News Highlights from NOA Lithium: NOA Lithium Discovers Fresh Water at Rio Grande Project NOA Engages Hatch To Lead Preliminary Economic Assessment For Its Rio Grande Project NOA Lithium Advances Towards 2025 Water Exploration at Rio Grande Project Read more about other lithium stocks: NASDAQ: PWM | OTC: LTMCF | NYSE: ALB | NYSE: LAC | OTCQB:NRVTF * Legal Disclaimer & Disclosure - Paid Advertisement: This content is a paid advertisement. Wall Street Wire has received compensation from NOA Lithium Brines Inc. for promotional media services provided on an ongoing subscription basis. This content is for informational purposes only and does not constitute financial advice. Wall Street Wire is not a broker-dealer or investment adviser. Full compensation details and information regarding the operator of Wall Street Wire are available here redditwire.com/terms or in NOA's disclosure's THIS ARTICLE CONTAINS SPONSORED CONTENT PUBLISHED ON BEHALF OF NOA LITHIUM BRINES Contact Details ‎ media.globalmarkets@gmail.com

June 24, 2025 09:18 AM Eastern Daylight Time