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Gordon Marketing Acquires Senior Elite Services

AmeriLife

Gordon Marketing, a national, independent and family-owned field marketing organization (FMO) and affiliate of AmeriLife Group, LLC (“AmeriLife”), announced today that it has acquired longtime partner Senior Elite Services, a full-service health, life and financial planning agency serving agents and their clients across the Midwest and Southeast United States. Per the agreement, terms of the deal were not disclosed. “Since 2011, Senior Elite Services has enjoyed a successful relationship with Gordon Marketing, and we’re excited to take it to the next level,” said Jonathan G. Acevedo, founder and president of Senior Elite Services. “Our expanded partnership will allow for even greater alignment with Gordon Marketing and AmeriLife, and help us assist even more agents who wish to follow in the same footsteps and achieve their goals and dreams.” Founded in 2008 and headquartered outside of Nashville in Fairview, Tennessee, Senior Elite Services trains its agents to take a holistic approach to their clients’ health and financial well-being. The agency employs a unique, self-generated lead model through its partnerships with local pharmacies and boasts a broad portfolio of Medicare, life insurance, and health specialty plans and annuities. A values-driven, minority-owned business, Senior Elite Services is deeply committed to the communities it serves, with a focus on breaking down the complexities of the insurance buying and financial planning process and providing clients with solutions that fit their unique needs. “The most successful partnerships often have strong roots, and the history between Senior Elite Services and Gordon Marketing is testament to that,” said Scotty Elliott, Chief Distribution Officer for AmeriLife Health. “I’m thrilled to welcome Jonathan and his team to the AmeriLife family of companies and excited for what’s to come for them as they tap into our best-in-class resources under the continued guidance of Rebecca and Sylvia Gordon and their incredible leadership team.” ### About Senior Elite Services Senior Elite Services, LLC (SES) is a full-service Medicare, life insurance and financial planning agency serving Tennessee since 2008. Founder and President Jonathan Acevedo and his team are licensed and bonded across the Midwest and Southeast in Tennessee, Michigan, Indiana, Ohio, Kentucky, Alabama, Georgia, Florida, Mississippi, Arkansas, North Carolina and South Carolina. SES offers help with all of its clients’ insurance options and retirement planning, taking the time to explain all the complexities to ensure they have the best benefits for their needs. For more information, visit SeniorEliteServices.com. About Gordon Marketing Founded in 1980 by Dick and Margaret Gordon, Gordon Marketing is an award-winning field marketing organization (FMO) committed to serving thousands of independent insurance agents nationwide. A third-generation, family-owned and operated company, Gordon Marketing specializes in senior-related health and life insurance products and offers a complete portfolio of annuity, Medicare Supplement and Long-Term Care solutions. From Medicare Basics and Advanced Compliance to other in-depth learning and development opportunities, Gordon Marketing offers the best-in-class training agents need to stay in business and succeed in the ever-changing insurance industry. For more information, visit GordonMarketing.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as a leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and 120 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. Contact Details Media Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Partnership Inquiries Patrick Nichols +1 727-726-0726 pnichols@amerilife.com Company Website https://amerilife.com/

October 17, 2023 09:00 AM Eastern Daylight Time

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Tiziana Life Sciences reveals "exciting" clinical data from latest MS trial

Tiziana Life Sciences PLC

Tiziana Life Sciences Ltd (NASDAQ:TLSA) chief medical officer and chief operating officer Matthew Davis speaks to Thomas Warner from Proactive after the clinical-stage biopharmaceutical company announced some fresh clinical results from its work in treating non-active secondary progressive multiple sclerosis (MS) with intranasal foralumab. The work has focused particularly on reducing the amount of fatigue experienced by MS sufferers. Davis emphasises that the fatigue experienced by MS patients is not the typical tiredness most people feel, but a debilitating condition that severely impacts their quality of life. In Tiziana's expanded access programme, four out of six patients showed a reduction in this fatigue - a ratio Davis describes as "exciting" considering the severe impact of fatigue on MS sufferers. The company's recent PET scan results and ongoing Phase 2a trials aim to further understand the drug's profile and help move it towards approval. Davis hinted that the next update from the company will focus on their Phase 2a trials. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 17, 2023 03:27 AM Eastern Daylight Time

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AI startup Leucine nets $7M to level up Pharma manufacturing compliance to keep pace with drug innovation

Leucine

Pharmaceutical manufacturing is the lynchpin to getting drug innovation to people. While compliance protocols are key to ensuring the smooth operation of the industry, they are beset by processes that are not fit for purpose and are hindering their ability to deliver life-saving drugs faster. Suffocated by paper-based records and legacy systems, the large-scale manufacturing of drugs is being hampered. It’s little wonder that a staggering 2 out of 3 FDA warnings are for non-compliance related to procedures not being followed appropriately, unclear work instructions of methods, failure to review equipment usage logs, and lack of shared procedures between Quality Assurance and production departments. These matters are often missed and go unnoticed because of the conventional paper-based systems in the pharmaceutical industry. Helping to make pharmaceutical manufacturing compliant, safer, and faster, tech startup Leucine is today announcing a $7M series A funding round led by Ecolab Inc., a strategic investor, to scale its Compliance Cloud platform globally. This round also saw participation from all existing investors, including Pravega Ventures, Axilor Ventures, Techstars, and angels. Vivek Gera, founder, and CEO of Leucine, commented: “Paper-based manufacturing records are the industry's achilles' heel, fueling not only regulatory nightmares but also ballooning production costs and inefficiencies. The legacy solutions are no better, with their extremely long implementation cycles and rigid, siloed applications that leave manufacturers in a lurch.” Leucine's Compliance Cloud serves as a digital twin of the pharma manufacturing shop floor, bringing real-time performance monitoring, compliance management, and actionable insights to the table. For pharma manufacturers, leveraging data can mean the difference between a successful batch and a costly recall. What differentiates Leucine from some of the legacy digitization tools is its AI-driven capabilities designed not only to digitize pharma manufacturing workflows faster but also to provide proactive insights that enable pharma companies to stay compliant and produce faster and in a cost-effective manner. Leucine's platform can be implemented in 8 weeks. This speed of implementation becomes possible because of the proprietary AI-enabled digital process builder based on Large Language Models (LLMs) that rapidly digitizes paper SOPs into execution-ready digital formats. "Our models are trained on a wealth of pharma data, which allows the platform to create custom workflows enriched with GxP compliance measures, enabling us to deliver unparalleled value at breakneck speed," added Vivek Gera. A batch execution procedure is the single most important document in pharma manufacturing. This rapid digitization capability reduces the digitization cycle of a batch record from 6-8 months to 3-5 days. Leucine is currently deployed at over 30 companies in over 300 pharma manufacturing facilities across 10 countries, including the US, India, Brazil, Mexico, UAE, and others. The company is today also announcing the beta launch of Leucine10x, a groundbreaking AI framework designed to serve as a co-pilot in pharmaceutical manufacturing processes. Leucine10x will revolutionize how decision-making is done in pharma manufacturing, enabling Production and Quality Assurance teams to achieve their organization goals with ease and confidence. Built on proprietary LLM technology, Leucine10x offers an army of AI co-pilots that perform highly specialized tasks such as digitizing paper-based SOPs, creating a digital twin of the shop floor, collaborating with Production Managers in creating dynamic production plans, thus ensuring on-time batch delivery. Most significant is their ability to speed up Root Cause Analysis (RCA) of deviations in the manufacturing process by quickly analyzing data, including text-based records, logs, and even staff interview transcripts, to identify potential issues or patterns that might not be readily apparent. Mustaq Singh Bijral, Co-founder and CPO of Leucine, said: "We're excited to share that Leucine10x is already operational in select customer facilities under a trusted tester agreement. The response has been incredibly positive, and due to high demand, we're currently enrolling new customers through a waitlist". The funding round will support Leucine in refining its AI capabilities and making its AI Co-pilot a trusted partner to the production and quality managers on the shop floor and in expanding its reach to more facilities and customers. “Vivek and Mustaq have been relentless in their mission to make pharma manufacturing safer. This latest funding round will enable Leucine to bring the power of LLMs and associated technologies to make significant advances in pharma manufacturing. We couldn’t be happier to support them in this quest” said Rohit Jain, Co-founder and Partner at Pravega Ventures. Pravega Ventures also invested in the Seed round of Leucine. Vivek Gera remarked: "We're just scratching the surface; our vision is to leverage AI and technology to bring safe medicine to patients across the world” About Leucine Leucine is at the forefront of digitizing pharmaceutical manufacturing, leveraging cutting-edge AI technologies to bring unprecedented efficiency and compliance to the shop floor. Our innovative solutions, from Batch Planning to Batch Release, aim to modernize traditional procedures, replacing paper-based records with a seamless, digital-first approach. Trusted by industry leaders, Leucine not only streamlines the manufacturing process but also delivers actionable insights through its AI-driven analytics dashboard, empowering pharma companies to produce safer and more effective medicines. Leucine is headquartered in New Jersey, United States. For more information, visit https://www.leucine.io/ About Pravega Ventures Pravega Ventures is an early stage Venture Capital fund that partners with passionate founders, who are leveraging technology to either disrupt existing markets or create new ones. Contact Details Leucine Sampada Bhootna +91 81458 07848 sampada.bhootna@leucinetech.com Company Website https://www.leucine.io/

October 16, 2023 09:00 AM Eastern Daylight Time

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Tiziana Life Sciences reports six-month PET scan results for MS patients

Tiziana Life Sciences PLC

Tiziana Life Sciences Ltd (NASDAQ:TLSA) chief medical officer and chief operating officer Matthew Davis speaks to Thomas Warner from Proactive after the clinical-stage biopharmaceutical company announced an update on the company's progress in treating non-active secondary progressive multiple sclerosis (MS). The latest six-month PET scan data reveals improvements in five out of six patients, echoing the positive results from the three-month scans. This breakthrough aligns with the drug's hypothesis, as published in the Proceedings of the National Academy of Science, which suggests the drug works by stabilising the brain's innate immunity. From a business perspective, Davis suggests the findings are significant. In the US, there's no FDA-approved treatment for this specific MS type, affecting approximately 200,000 patients. Tiziana Life Sciences is gearing up for its phase 2a programme, focusing on PET change as a primary endpoint. Davis also highlights that he addressed the importance of targeting neuroinflammation in MS and Alzheimer's during a keynote speech in Milan this week. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 16, 2023 08:00 AM Eastern Daylight Time

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Faron Pharmaceuticals CEO delighted with latest BEXMAB study findings

Faron Pharmaceuticals Oy

Faron Pharmaceuticals Limited (AIM:FARN, OTC:FPHAF) chief executive Dr Markku Jalkanen speaks to Thomas Warner from Proactive London after the clinical stage biopharmaceutical company revealed fresh data from the company's ongoing phase I/II trial. Its BEXMAB study is evaluating the efficacy of bexmarilimab in treating acute myeloid leukaemia (AML) and myelodysplastic syndromes (MDS). Jalkanen explains that the results show that bexmarilimab achieved a 50% remission rate among 22 patients who had relapsed or were refractory to standard treatments, including hypomethylating agents (HMAs). Of the 22 patients, eight achieved complete remission, indicating that their symptoms were entirely eradicated or significantly reduced. Looking forward, he says the results "mean that the program we have been planning to take the clinical development all the way to the marketing approval, and we have said that we could actually file the PLA in 2025. These results really support that view... I'm anticipating not to have really huge massive clinical trial size any more for this project - we're probably looking at 50-100 patients all in." Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 16, 2023 06:15 AM Eastern Daylight Time

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Don't Let Osteoarthritis Hold You Back

YourUpdateTV

Do you or someone you know have pain in your joints or stiffness when doing daily activities? These symptoms may be related to a common condition called osteoarthritis and it affects more than 32.5 million adults in the U.S. Recently, Dr. Sherri Betz, PT, DPT, a physical therapist and spokesperson for the American Physical Therapy Association, conducted a satellite media tour to talk about how physical therapy can treat and help people manage the symptoms of osteoarthritis. A video accompanying this announcement is available at: https://youtu.be/7OIFKIUNuxA Osteoarthritis, or OA, is the most common form of arthritis. Some people call it degenerative joint disease or “wear and tear” arthritis. It occurs most frequently in the hands, hips, and knees. ( CDC ). The signs and symptoms of OA can vary, so the approach to care also will vary. Common symptoms include stiffness in joint(s), pain during activity, and cracking or creaking noise around the joint. Physical therapists work with their patients and clients to develop treatment plans specific to each person’s needs and goals. Although osteoarthritis cannot be reversed, osteoarthritis symptoms often can be effectively managed through conservative approaches like exercise and treatment by a physical therapist. Regular physical activity can help maintain and improve movement and function and reduce joint pain for people with arthritis. The knees are among the joints most commonly affected by osteoarthritis, with nearly 12.4 million people ages 65 or older having symptomatic knee OA. Some individuals may receive multiple steroid injections to treat their OA; however, research shows that physical therapy is an effective treatment option for OA of the knee. A new report just released by the American Physical Therapy Association found that, compared with injections, physical therapy for OA of the knee offers similar improvements sooner. The report also calculated the economic impact of choosing physical therapy for OA of the knee over steroid injections and found that doing so saves close to $14,000, including all the hidden costs of your time, pain, missed life events, and the dollars paid for services. For more information visit ChoosePT.com About Sherri Betz, PT, DPT APTA spokesperson Sherri Betz is a physical therapist and director of TheraPilates Physical Therapy in Louisiana, specializing in geriatrics and osteoporosis. Betz is devoted to improving awareness about geriatric exercise, bone health, and safe yoga and Pilates-based exercise through professional and consumer education as well as through the promotion of low-cost, on-site, and virtual community exercise programs for older adults. She serves on the Bone Health & Osteoporosis Foundation’s Exercise and Rehabilitation Activities Council as APTA’s liaison, as well as the American Bone Health’s Professional Education Committee. Betz also serves as chair of Pilates Method Alliance's Research Committee and is past chair of the PMA Certification Commission and board vice president. She is a graduate of Louisiana State University’s physical therapy program and received a Doctor of Physical Therapy degree from EIM Institute of Health Professions. She is a board-certified clinical specialist in geriatric physical therapy. She also is a nationally certified NPCP Pilates teacher and a certified exercise expert for aging adults. Betz is a recipient of both the PMA's Deborah Lessen award for her many years of dedicated service to PMA and the APTA Geriatrics' Lynn Phillippi Advocacy for Older Adults award. She has published numerous articles, authored book chapters, produced videos, and speaks internationally about exercise for osteoporosis. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 12, 2023 11:46 AM Eastern Daylight Time

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Demand for Online Writing and Content Creation Jobs Intensifies, finds Freelancer.com

FREELANCER.COM

Freelancer.com (ASX: FLN) (OTCQX: FLNCF), the world’s largest freelancing and crowdsourcing marketplace by number of users and jobs posted, today released its quarterly report revealing the most in-demand online jobs on the platform for Q3 2023. The Fast 50 Q3 2023 report, a quarterly dataset ranking the fastest growing and falling jobs on the platform, analyzed over 277,000 jobs posted by employers to Freelancer.com between July and September 2023. According to the data, the fastest growing freelance jobs by percentage growth in Q3 2023 were mostly writing, content creation and marketing related. As AI continues to advance, the need for human creativity remains strong. Employers are once again seeking freelancers to support with Creative Writing and Content Writing projects, which are up 22.4% and 19.4% respectively. A surge in demand for writing skills across the platform means there were more than 10,000 additional writing projects available in Q3 2023, which were already a trending skill evident in the previous quarter. The Q3 2023 data also indicates a consistent trend in businesses seeking freelance marketing support, with Search Engine Marketing (up 24.1%), Videography (up 17.4%) and Telemarketing (up 16.5%) seeing notable growth across the quarter. This aligns with the previous quarter's emphasis on business marketing activities. “Our Freelancer Fast 50 Report is a forward leading indicator of the skills and expertise businesses need today. Artificial Intelligence is powering a boom in content creation, particularly focusing on writing, marketing and video production skills” said Matt Barrie, Chief Executive at Freelancer. “Generative AI is superskilling freelancers and their ability to produce extremely high quality content and faster than ever before. Tools like ChatGPT and Bard have changed the game when it comes to producing and refining written content, while advances in video AI such as Runway Gen-2, HeyGen and Pika Labs means that video production and editing can be done with a click of a button.” Growth in skills like User Interface / IA (up 17.4% from 3,071 to 3,607) and UX / User Experience (up 13.9% from 1,193 to 1,359) highlight the importance of user-centric design in today's digital landscape. Data Mining (up 14.9% from 2,374 to 2,728) and Data Processing (up 10% from 11,013 to 12,115) were also amongst the top growing jobs. These skills are often associated with Sales functions and Lead Generation, which are also growing in the quarter, up 13.3% and 11.4% respectively. By leveraging freelancers to research leads, businesses can operate more efficiently and focus more on relationship building in the sales process. Design, Marketing and Video Creation Jobs Lead Year-on-Year Growth Several skills have surged in demand when comparing Q3 2022 and Q3 2023. Jobs for User Interface (UI) Design have doubled, growing by 101.9% to 3,607 from 1,786 in the same period last year. Search Engine Marketing jobs grew 80.4% (from 1,597 to 2,881) and Videography jumped by 77.1% (from 2,716 to 4,809). Fastest Falling Jobs of Q3 2023 The recent data highlights a shift in the demand for specific technical skills, which saw a significant increase last year as many tech companies laid off technical staff. There's a noticeable decline in jobs for certain established programming languages and frameworks. For instance, Matlab and Mathematica saw a 25.1% decrease (from 1,349 to 1,011 jobs). Similarly, projects requiring skills in AngularJS jobs dropped by 23.5% (from 1,722 to 1,318), while those requiring Django experts experienced a decline of 23.4% (from 1,216 to 932). C Programming, C++ Programming, and Python, which were all in-demand skills in Q3 2022, also all decreased on the platform in Q3 2023. While algorithms remain integral to many processes, there's been a reduction in specialized roles in this domain. This trend is evident in the decrease in demand for Algorithm skills, which saw a decrease of 22.5% (from 1,438 to 1,114 jobs). This might be a consequence of the advent of more intuitive tools and platforms that simplify algorithmic tasks. __________________________________________________________________________________________________ Fast 50 Q1 2023 - Data Analysis Writing Jobs Show No Sign Of Slowing Down The introduction of highly sophisticated and powerful generative AI tools have led many experts and commentators to predict that skills such as writing will be replaced by AI. However, the latest Fast 50 Q3 data demonstrates that writing jobs are here to stay, as content writing, creative writing, copy typing and ghostwriting jobs increase by more than 20% over the last quarter. These skills continue to flourish after reporting growth in the previous quarter on Freelancer.com, with Creative Writing ranked as the fastest growing skills in Q2 2023 (up 58%, from 1,868 to 2,961). An Increase in writing skills for two quarters in a row suggest that businesses are placing more emphasis on content creation by hiring freelancers to write articles and produce creative content. Copy Typing, the fastest growing skill for Q3’23 (up 28.7% from 6,381 to 8,213) encompasses all types of jobs from data entry to helping write e-books to transcription and typist projects. While technical projects do require degrees and past experience, most copy typing jobs can be performed by freelancers with no prior knowledge, making it a lucrative side hustle for freelancers globally. AI’s Impact on Whitecollar Jobs While writing jobs continue to flourish over the past 6 months, there is a need to understand how generative AI will impact jobs and various freelancing skills. In a longform essay titled ‘ AI know what you did last summer ’, Freelancer.com CEO Matt Barrie discusses the bleeding edge of AI technology and how he predicts these will go on the shape white-collar jobs. Barrie suggests that to be competitive in a world of AI, workers will need to adapt or move up the stack: “Those in white collar jobs will need to move ‘up the stack’. Illustrators become cinematographers. Writers become editors. Software developers become product managers. Grad students now run a research group.” Barrie also highlights that there is a major opportunity for freelancers, arguing that AI-powered freelancers will ultimately be the winners as they have the ability to compete against middle class workforces all around the world. AI’s impact on work productivity is evident in a recent AI study conducted by Freelancer.com which found that in a survey of over 1,300 US workers, a majority of those US workers (75%) are using generative AI tools in their work. One in three (33%) workers are using AI tools all the time in their work, while one quarter of US workers (25%) are using these tools sometimes and one sixth (16%) admit to never using AI at work. Marketing & Video Production Sustain Growth, Growing Every Quarter in 2023 Marketing and Video Production skills are one of the most in-demand skill categories on the platform, with data showing they’ve now grown every quarter since the beginning of the year. Search Engine Marketing (up 24.1%, from 2,321 to 2,881) ranked as the third fastest growing skill on the platform. Telemarketing (up 16.5%, from 1,054 to 1,228) has grown in Q3 as businesses turn towards more traditional marketing tactics. Sustained growth in different types of marketing skills means there are many opportunities for skilled freelancers to find unique projects on the platform. As for video production, not only is the skill up quarter-on-quarter, but both Video Production and Videography have almost doubled when compared to the same time last year, up 58.1% and 77.1% respectively. The surge in freelancer video production jobs can be attributed to the booming demand for online content, especially on platforms like YouTube (up 10.3%, from 1,174 to 1,295 jobs in Q3) and TikTok. As content is a staple in many marketing strategies, businesses are turning to freelancers to help them produce content, boosting this as a potential category for workers. Businesses Delegating Sales Functions to Freelancers As found in the Freelancer.com World’s Most Boring Job research, businesses often delegate research heavy tasks to on-demand freelancers. In turn, this allows businesses the ability to operate more efficiently and focus on more impact-based tasks. A unique trend uncovered in the Fast 50 Q3 2023 shows that businesses are leaning on freelancers to help with the research portion of the sales function. Sales and Lead Generation ranked as some of the fastest growing jobs in the quarter, up 13.3% and 11.4% respectively. Interestingly, Sales and Lead Generation both featured in the top 25 fastest growing jobs in Q2 2023. Growth in sales and lead generation is an example of how businesses are employing freelancers to help them streamline the sales process. ###### Freelancer Fast 50 The Freelancer Fast 50 report is the world’s largest forward indicator of trends in online jobs related to industries, technologies, products, and companies. The data is based on 277,000 jobs posted to the Freelancer.com platform between July 1 to September 30 2023. Fast 50 Q3 2022 vs Q3 2023 Fast 50 Q2 2023 vs Q3 2023 Data About Freelancer Twelve-time Webby award-winning Freelancer.com is the world’s largest freelancing and crowdsourcing marketplace by total number of users and projects posted. More than 69 million registered users have posted over 23.1 million projects and contests to date in over 2,000 areas as diverse as website development, logo design, marketing, copywriting, astrophysics, aerospace engineering and manufacturing. Freelancer owns Escrow.com, the leading provider of secure online payments and online transaction management for consumers and businesses on the Internet with over US$5 billion in transactions secured. Freelancer also owns Freightlancer & Loadshift, enterprise freight marketplaces with over 550 million kilometers of freight posted since inception. Freelancer Limited is listed on the Australian Securities Exchange under the ticker ASX:FLN and is quoted on OTCQX Best Market under the ticker FLNCF. Forward-looking statements This document contains certain "forward-looking statements". The words "anticipate", "believe", "expect", "project", "forecast", "estimate", “outlook”, “upside”, "likely", "intend", "should", "could", "may", "target", "plan" and other similar expressions are intended to identify forward-looking statements. Indications of, and guidance on, future earnings and financial position and performance, including Freelancer’s FY23 outlook, are also forward-looking statements, as are statements regarding Freelancer’s plans and strategies and the development of the market. Such forward-looking statements are not guarantees of future performance and involve known and unknown risks, uncertainties and other factors, many of which are beyond the control of Freelancer, which may cause actual results to differ materially from those expressed or implied in such statements. Freelancer cannot give any assurance or guarantee that the assumptions upon which management based its forward-looking statements will prove to be correct or exhaustive beyond the date of its making, or that Freelancer's business and operations will not be affected by other factors not currently foreseeable by management or beyond its control. Such forward-looking statements only speak as at the date of this announcement and Freelancer assumes no obligation to update such information. The release, publication or distribution of this document in jurisdictions outside Australia may be restricted by law. Any failure to comply with such restrictions may constitute a violation of applicable securities laws. Contact Details Freelancer.com Marko Zitko +61 404 574 830 mzitko@freelancer.com

October 12, 2023 07:09 AM Pacific Daylight Time

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The Promise Of Psilocybin When It Comes To Mental Health, And How COMPASS Pathways (NASDAQ: CMPS) Is Advancing It

COMPASS Pathways

By Faith Ashmore, Benzinga Recent advancements in understanding mental health and the brain have allowed us to identify possible commonalities between different mental health conditions. One of the shared experiences among patients with conditions like treatment-resistant depression (TRD), bipolar II disorder and PTSD is the inability to move on and the presence of repetitive thoughts or ruminations. These thoughts can be persistent, counterproductive and even self-destructive. Patients often describe feeling disconnected from the world including friends and family. Although our ability to measure brain activity in humans is limited, doctors can use magnetic resonance imaging (MRI) to observe blood flow, which is closely linked to brain activity. When there is an increase in blood flow in a specific area, it indicates increased local activity, particularly at synapses. The brain is a highly energy-demanding organ, and different parts of the brain tend to fire together as modules rather than operating as completely independent entities. These modules control various functions such as vision, sensory/motor control of movement, the emotions, attention and even a default mode network associated with rumination and internal dialogues. This default mode network is where patients may experience the persistent and intrusive self-critical voice in their minds. In a number of mental health conditions, these functional modules appear to be more connected within and less between each other compared to individuals without the condition. Understanding the commonalities revealed by human imaging studies across conditions offers valuable insights for rethinking treatment approaches and providing proper care, especially for patients with unmet needs. This is why the world of psychedelics is especially promising when it comes to mental health care. Drugs producing psychedelic experiences have shown promise in treating mental health conditions, perhaps by disrupting the connectivity of functional modules altered in depression, anxiety, and other conditions. For example, by reducing activity in the default mode network, it has been suggested that these drugs may also help individuals break negative thought patterns and ruminations. Animal studies suggest that they may help in promoting neuroplasticity and repairing neural circuits, which may lead to improved and sustained mental health outcomes in some patients. This potential is exciting and more research is needed to understand how psychedelics may be used. COMPASS Pathways’ (NASDAQ: CMPS) innovative approach has received FDA Breakthrough Therapy designation in the U.S. and Innovative Licensing and Access Pathway designation in the U.K. for their investigational COMP360 psilocybin in TRD. Moreover, in late 2021, COMPASS Pathways announced the completion of a randomized, controlled double-blind phase 2b study of investigational COMP360 psilocybin treatment involving 233 patients with TRD in 22 sites across Europe and North America. While the company is currently focusing on TRD, it is also researching PTSD and anorexia nervosa, in part because of neurological similarities. Companies like COMPASS Pathways are working to develop interventions that address these common factors and support patients on their path toward improved mental well-being. For patients who have found no relief with current medications, this would be meaningful progress. Company BioCOMPASS Pathways plc (Nasdaq: CMPS) is a mental health care company dedicated to accelerating patient access to evidence-based innovation in mental health. Our focus is on improving the lives of those who are suffering with mental health challenges and who are not helped by current treatments. We are pioneering the development of a new model of psilocybin therapy, in which our proprietary formulation of synthetic psilocybin, COMP360, is administered in conjunction with psychological support. COMP360 has been designated a Breakthrough Therapy by the U.S. Food and Drug Administration (FDA) and has received Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD). We have commenced a phase 3 clinical program of COMP 360 psilocybin therapy in TRD, the largest randomised, controlled, double-blind psilocybin therapy clinical program ever conducted. Previously, we completed a phase 2b study with top line data showing a statistically significant (p<0.001) and clinically relevant improvement in depressive symptom severity after three weeks for patients who received a single high dose of COMP360 psilocybin with psychological support. We are also conducting phase 2 clinical studies of COMP360 psilocybin therapy for post-traumatic stress disorder (PTSD) and anorexia nervosa. COMPASS is headquartered in London, UK, with offices in New York and San Francisco in the United States. Our vision is a world of mental wellbeing. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Stephen Schultz stephen.schultz@compasspathways.com

October 12, 2023 09:15 AM Eastern Daylight Time

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Josephine Antonellis and Julie Harris, Ph.D., Named to New Roles at Cure Alzheimer’s Fund

Alzheimer’s Disease Research Foundation

Cure Alzheimer’s Fund announces Josephine (Jo) Antonellis has been named Chief Financial Officer (CFO) and Julie Harris, Ph.D., has been named Executive Vice President, Research Management for the nonprofit organization. As CFO, Antonellis will be responsible for the financial management of the nonprofit organization, including leadership of the accounting and financial teams. She will be a member of the management committee and report directly to Meg Smith, Chief Executive Officer. “We are fortunate to have a person with Jo’s depth and breadth of experience to lead our financial operations,” said Smith. “Jo has played a key role as our Controller and I expect she will move seamlessly into the CFO role, ensuring continuity of all our financial operations.” Antonellis joined Cure Alzheimer’s Fund in 2021 as Controller. She came to the organization with more than 25 years of diverse accounting experience, including responsibility for accounting operations and human resource functions. She started her career as an auditor for Arthur Andersen, where she became a licensed CPA. She holds a B.S. in accounting from Bentley University. Harris will be responsible for research management and funding for Cure Alzheimer’s Fund in her new role. She will bring new ideas and perspectives to managing the research portfolio, and partner with the scientific community to further the nonprofit’s mission to eradicate Alzheimer’s disease. “When we hired Julie, I knew that her deep experience as a scientist and as the central leader of large scientific teams and projects meant that she would be an immediate contributor to our research program,” said Smith. “Julie has also shown us all that she is a natural ambassador for our science, our scientists and our organization.” Prior to joining CureAlz, Harris was vice president of preclinical biology at Cajal Neuroscience, a biotech startup focused on identifying novel therapies for neurodegenerative diseases. Before that, she spent 10 years at the Allen Institute for Brain Science, where her team was responsible for employing whole brain microscopy and transcriptomics in Alzheimer’s mouse models to characterize molecular, cellular and circuit patterns of disease. Harris received a B.S. in zoology from Michigan State University and a Ph.D. in neurobiology and behavior from the University of Washington. She trained as a postdoctoral fellow at the Gladstone Institute of Neurological Disease in San Francisco. Since its founding in 2004, Cure Alzheimer’s Fund has provided grants to more than 750 of the world’s leading researchers and contributed more than $175 million to research. Its funded initiatives have been responsible for many key breakthroughs in understanding the causes and pathology of Alzheimer’s disease. Cure Alzheimer’s Fund has received a 4-star rating for 12 consecutive years from Charity Navigator. With 100% of funds raised going to support research, Cure Alzheimer’s Fund has been able to provide grants to many of the best scientific minds in the field of Alzheimer’s research. For more information, please visit https://www.CureAlz.org/. Contact Details Cure Alzheimer's Fund Barbara Chambers +1 978-417-9890 bchambers@curealz.org

October 12, 2023 06:53 AM Eastern Daylight Time

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