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PathAI Announces Research Presentations at the 2024 AACR Annual Meeting

PathAI

PathAI, Inc., a leading AI-powered precision pathology company, today announced it will present research from its portfolio of oncology products at the AACR Annual Meeting on April 7-10, 2024, in San Diego, CA. The research demonstrates how machine learning models developed to characterize the tumor microenvironment (TME) from routine hematoxylin and eosin (H&E)-stained whole slide images (WSIs) can be used to advance biomarker development and precision medicine strategies. The presentations include new research leveraging PathAI’s pan-tumor foundation models and its commercially available product, PathExplore 1, to identify key histologic features associated with molecular signatures and patient response to therapy. Highlights: Researchers deployed PathExplore on HNSCC and NSCLC samples to characterize the cell and tissue composition of the tumor microenvironment, as well as compute immune phenotypes directly from H&E WSI. (Poster #905 ) Researchers from Incendia Therapeutics developed a continuous scoring method for Discoidin Domain Receptor 1 (DDR1), which revealed widespread immune exclusion in tumors based on the spatial distribution of lymphocytes, CD8+ T cells, and CD45+ immune cells from H&E and mIF images. DDR1 is highly expressed in epithelial cancers and has been implicated in tumor growth, invasion, and lack of response to therapy. The immune exclusion score correlates with DDR1 mRNA and protein expression. The study provides additional insight into the role of DDR1 in human cancers and may be useful in selecting indications and stratifying patients for DDR1-targeted therapies. (Poster #2916 ) Using unsupervised learning driven by PathExplore’s features and a novel collagen fiber detection imaging technology, researchers discovered three distinct phenotypes of cancer associated stroma (CAS) that had distinct patterns of association with survival and gene expression signatures. Two of them were enriched in collagen fiber density as well as in density of fibroblasts, while the third phenotype had the highest density of immune cells, providing a categorization of different types of CAS-tumor interaction that may be useful for patient stratification. (Poster #4912 ) Using AI-powered models from PathAI, Foundation Medicine researchers investigated digital pathology TME features of immunotherapy outcomes among NSCLC patients within a real-world dataset from the Flatiron Health-Foundation Medicine Clinico-Genomic Database. These results indicate that the composition of the TME assessed via digital pathology may have utility in identifying NSCLC patients who will respond to first-line immune checkpoint inhibitors beyond the established immunotherapy biomarkers. (Poster #4969 ) In collaboration with EMD Serono, AI-powered TME models from PathAI were used to analyze H&E WSI of NSCLC from a randomized Phase 3 trial directly comparing two immunotherapies. Researchers compared cell abundance features with gene expression data from the same samples and found that immune and stromal cell abundance features were associated with expression of genes in relevant cellular pathways, confirming the biological relevance of our cellular features. In analyzing the features alongside the clinical data from the retrospective study, researchers identified candidate prognostic immunotherapy biomarkers. (Poster #6179 ) Researchers from Incendia Therapeutics illustrated that morphologic features derived from H&E images using PathExplore can be effective predictors of CD8-defined immune exclusion, providing an option for patient stratification by immune phenotype using widely available H&E images. The features and direction of association align with prior knowledge of the mechanism or manifestations of immune exclusion or infiltration in the TME, including the relative density of lymphocytes in tumor and stroma. (Poster #7392 ) PathAI’s pan-tumor foundation models were used to identify tissue regions and cell types on H&E WSI to quantify tumor purity across multiple tumor types. Model-derived tumor purity estimates were compared to three orthogonal molecular methods of purity and found to correlate across disease indications. These results provide evidence of how AI can improve the efficiency of molecular testing and enhance precision diagnostic strategies. (Poster #7402 ) Follow PathAI on LinkedIn and X for more updates from #AACR24 and visit us in person at booth #1549. 1 PathExplore is For Research Use Only. Not for use in diagnostic procedures. About PathAI PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and laboratory use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of pathology samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

April 03, 2024 10:00 AM Eastern Daylight Time

LOTUS NETWORK BRINGS THE “SHMEALER” TO THE FRONT RANGE FOR ITS SPRING CONNECTOR EVENT

Lotus Network

Lotus Network, a Denver-based non-profit organization providing opportunities for all women to create meaningful connections, announced today its 2024 Spring Connector event, Reigniting the Women’s Spirit, featuring the “Shmealer” (shame healer) Sarah Lajeunesse. An award-winning coach, writer and speaker, Lajeunesse brings Reigniting the Women’s Spirit to the U.S. for the first time at this Lotus Network event. The discussion will explore how the weight of perfectionism, people-pleasing, societal, cultural and gender expectations and pressures, are deeply rooted in guilt and shame. Touching upon the ways these self-conscious emotions can prevent a woman from experiencing a greater, richer quality of life, this timely talk will explore the yearning so many women experience in wanting to feel whole and empowered. Through a hilariously liberating and thought-provoking discussion about uncomfortable emotions, “ Reigniting the Women’s Spirit” is aimed at helping women: Identify and challenge their own personal limiting beliefs and unrelenting patterns that keep them stuck Set healthy boundaries and communicate them effectively with others Cultivate self-compassion and self-care practices that nurture well-being and happiness Uncover individual strengths for achieving self-confidence Lajeunesse will provide tips on how to release the heavy, unnecessary burden of shame that has continued to plague many women for years, decades and even generations. She will also address ways to stop the unconscious passing down of guilt and shame repercussions throughout life. The Spring Connector event will be held on Tuesday, May 7, 2024 from 7:00–9:00 P.M. at the Leach Center for the Performing Arts on the Colorado Academy campus, 3800 South Pierce Street, Denver, CO, 80235. Lotus Network’s hope for the event is that all women – mothers, daughters, sisters and friends – become more empowered to make important and necessary journeys to reclaim their voices, choices and lives by releasing guilt and shame to better trust themselves. “Reflecting Lotus Network’s founding mantra of ‘It’s Never Too Late...,’ we bring the Front Range a premier event to which we believe so many women can relate. Empowering women through connection is a global, topical conversation that we are bringing to the forefront through Sarah’s first U.S. discussion. Our goal for this event – and all our programming – is to truly connect women and provide them platforms and tools for learning, growth and self-discovery,” Lotus Network Co-founders Lisa Cook and Leslie Heins explained. Tickets are $35 for Reigniting the Women’s Spirit Event and can be purchased at Connector Event 2024 Featuring Sarah Lajeunesse - Lotus Network There also will be a VIP Meet & Greet event with Lajeunesse on Monday, May 6 th. In addition, the event will be offered via a virtual platform for out-of-state participants. For more information on ticket purchases and the event, please contact sue@lotusnetwork.org. HealthONE Rose Women's Hospital is the sponsor behind Lotus Network’s Spring Connector event. About Sarah Lajeunesse Sarah Lajeunesse is an award-winning coach, writer, speaker and “shmealer” (shame healer) whose work is devoted to helping women heal the guilt, shame and past experiences that prevent them from moving toward a greater, richer quality of life. From working with, speaking to and supporting hundreds of individuals across several countries, ranging from teens to those in their 60’s and in various phases and stages of life, she’s witnessed the long-term damage and detrimental impacts the weight of shame can carry. Visit the Shmealer at https://www.sarahlajeunesse.com/. About Lotus Network In 2019, best friends and business partners Lisa Cook and Leslie Heins founded Lotus Network, a nonprofit organization raising awareness of purposeful living by inspiring women of all ages to live in authentic and gratifying ways through connection. Lotus Network encourages women to start their next chapter by taking on new challenges – physically, mentally and spiritually – by spreading the message that age is not a limitation. Lotus Network’s pillars include connection, empowerment, integrity, optimism and purpose. Please visit https://lotusnetwork.org and connect with the organization on Facebook, Instagram and LinkedIn to learn more. Contact Details Susan J. Turkell +1 303-766-4343 sturkell@pairelations.com Company Website https://lotusnetwork.org/

April 03, 2024 08:00 AM Mountain Daylight Time

IGC Pharma Releases Positive Interim Analysis Of Its Ongoing Phase 2 Trial In Alzheimer's Research

IGC Pharma, Inc. (IGC)

By Faith Ashmore, Benzinga As of 2023, the estimated number of Americans living with Alzheimer’s disease was 6.7 million. However, a lesser-known subsection of Alzheimer’s is Agitation in dementia from Alzheimer’s Disease (AAD). Recent research suggests that up to 76% of individuals with Alzheimer's also suffer from AAD. AAD is known to contribute to accelerated cognitive decline, increased burden on caregivers, higher rates of hospitalization and a greater need for medication – which collectively significantly diminish patients’ quality of life. Unfortunately, existing therapies for AAD carry black-box warnings, indicating the potential for serious adverse reactions that can result in death or serious injury. AAD has been associated with neuroinflammation, neurotransmitter imbalance and CB1 receptor dysfunctions. Research has also shown that AAD correlates with an upregulation of the inflammasome-3 and can contribute to neuroinflammation, ultimately leading to aggressive behavior. IGC Pharma (AMEX: IGC) is looking to provide treatment for millions of Americans struggling with ADD; its current drug, IGC-AD1, has been specifically designed to target the underlying causes of AAD and aims to fill the gap for a safe and effective therapy. Promising Clinical Studies For IGC-AD1 IGC-AD1 is undergoing extensive clinical trials to evaluate its effectiveness and safety in treating Alzheimer's disease. The phase two clinical trial, begun in 2023, encompasses 20 sites across the United States and Canada. With a target of 146 participants, this trial focuses on determining the efficacy of IGC-AD1 in alleviating agitation, a common symptom experienced by many Alzheimer's patients. The company has just announced the results of an interim analysis of its ongoing phase 2 trial. The main objective of the study is to evaluate the change in AAD over six weeks, utilizing the Cohen Mansfield Agitation Inventory (CMAI). The study showed that patients who were given IGC-AD1 had a more significant reduction in agitation levels compared to those who were given a placebo, with positive effects being observed as early as week two of the trial. At the six-week mark, the difference in agitation levels between the IGC-AD1 group and the placebo group was quite noticeable, with an effect size of 0.66 according to Cohen's d measure. The mean difference in the CMAI scores between the active treatment and placebo was -10.45, which indicates a meaningful contrast. Additionally, at the two-week mark, a secondary evaluation showed a positive effect size of 0.79 for IGC-AD1 compared to the placebo. "We are excited with the positive interim results from the Phase 2 trial of IGC-AD1 for agitation in dementia due to Alzheimer's disease. IGC-AD1’s interim results demonstrate a clinical and statistically significant reduction in agitation compared to placebo, suggesting a strong plausibility to address a substantial unmet medical need. This interim data validates IGC-AD1's potential as a transformative therapeutic option with a large market opportunity in Alzheimer's disease management,” said Ram Mukunda, CEO of IGC Pharma. “We are actively pursuing next steps, including with regulators, and remain committed to advancing IGC-AD1 toward commercialization. We foresee a medication that can help alleviate caregiver burden and family distress as managing Alzheimer’s patients, especially ones with agitation, can have a significant emotional toll on families. With IGC-AD1's promising clinical profile, we are confident in its ability, subject to further trials, to improve patient outcomes and drive shareholder value,” he added. In 2023, Alzheimer’s and other types of dementia were projected to cost the U.S. $345 billion. By 2050, these costs could rise to nearly $1 trillion. IGC-AD1 offers a glimmer of hope for the millions of individuals living with Alzheimer's disease, as well as their families. Featured photo by Ravi Patel on Unsplash IGC Pharma Inc. (IGC) is at the forefront of the fight against Alzheimer's disease, developing innovative solutions to address this devastating illness. The company's mission is to transform the landscape of Alzheimer's treatment with a robust pipeline of five promising drug candidates. IGC-AD1 and LMP target the hallmarks of Alzheimer's disease, including neuroinflammation, Aβ plaques, and neurofibrillary tangles. IGC-AD1 is currently undergoing a Phase 2b clinical trial for agitation in dementia associated with Alzheimer's (clinicaltrials.gov, CT05543681). TGR-63 disrupts the progression of Alzheimer's by targeting Aβ plaques. IGC-M3, currently in preclinical development, aims to inhibit the aggregation of Aβ plaques, potentially impacting early-stage Alzheimer's. IGC-1C, also in preclinical stages, targets tau protein and neurofibrillary tangles, representing a forward-thinking approach to Alzheimer's therapy. In addition to its drug development pipeline, IGC Pharma is actively leveraging Artificial Intelligence (AI) for Alzheimer's research. Their AI projects encompass various areas, including clinical trial optimization and early detection of Alzheimer's. These forward-looking statements are based largely on IGC Pharma’s expectations and are subject to several risks and uncertainties, certain of which are beyond IGC Pharma’s control. Actual results could differ materially from these forward-looking statements as a result of, among other factors, the Company’s failure or inability to commercialize one or more of the Company’s products or technologies, including the products or formulations described in this release, or failure to obtain regulatory approval for the products or formulations, where required, or government regulations affecting AI or the AI algorithms not working as intended or producing accurate predictions; general economic conditions that are less favorable than expected; the FDA’s general position regarding cannabis- and hemp-based products; and other factors, many of which are discussed in IGC Pharma’s U.S. Securities and Exchange Commission ("SEC") filings. IGC Pharma incorporates by reference the human trial disclosures and Risk Factors identified in its Annual Report on Form 10-K filed with the SEC on July 7, 2023, and Quarterly Report on Form 10-Q filed with the SEC on February 14, 2024, as if fully incorporated and restated herein. Considering these risks and uncertainties, there can be no assurance that the forward-looking information contained in this release will occur. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Rosalyn Christian rchristian@imsinvestorrelations.com Company Website https://igcpharma.com/

April 03, 2024 09:00 AM Eastern Daylight Time

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Sharps Technology's Global Expansion: Achieving Key Milestones To Strengthen Market Position

Benzinga

by Kenneth Adams, Benzinga Sharps Technology, Inc. (NASDAQ: STSS), an innovative medical device and pharmaceutical packaging company, and Roncadelle Operations, an Italian-based driving force in the development of novel medical drug delivery devices announced a collaboration aimed at transforming the landscape of drug delivery systems worldwide. This strategic partnership encompasses a series of agreements and initiatives designed to enhance market access, drive collaboration and innovation and promote patient safety worldwide. The partnership commenced in mid-January with the signing of a Letter of Intent (LOI) between Sharps Technology and Roncadelle Operations to enter into a sales and marketing agreement that would enable Sharps and Roncadelle to cooperatively sell and distribute each other’s products to their respective areas of influence and expand Sharps’ American-based product market into Europe, the Middle East, Africa and the Asia-Pacific region. By mid-February Sharps began working with Owens & Minor, a leading global healthcare logistics supplier, to establish a 3PL and distribution network across North and South America for both the Sharps and Roncadelle lines of smart disposable safety syringes. “We are excited about this opportunity to collaborate with Roncadelle, a premier manufacturer of smart safety syringes and a leader in the development of drug delivery systems, to expand both our solution offerings in the U.S. and our reach into the world market,” commented Sharps Technology CEO Robert Hayes. “This agreement is very beneficial for both of our companies.” Sharps Technology specializes in the development and manufacturing of innovative drug delivery systems. The company’s Securegard and Sologard product lines focus on low-waste and ultra-low waste syringe technologies that incorporate both active safety features and World Health Organization-accredited reuse prevention measures. Roncadelle’s SafeR Retractable Safety Syringe and needles offer a passive safety system with both auto-disable and reuse prevention features. “Sharing our product portfolio gives our healthcare customers, from large pharmaceutical companies to startup biologics, access to a broad range of solutions and price points to match even their most challenging requirements. This will open up a completely new level of service to the market,” states Ben Scheu, Sharps’ Senior Director of Sales. Sharps reports that the synergy between Sharps and Roncadelle will bring together more than 30 established distribution points with Sharps’ new Owens & Minor partnerships to deliver products to the world healthcare market that stand for simplicity of use and are unparalleled in safety and patient protection, setting new global standards to safeguard people from infection and disease. The business alliance additionally potentially creates a very important player in advancing syringe market opportunities through the development of unique technologies such as prefilled syringes, needle guard systems, auto-injectors and injector pen devices. “It is exciting to see how well our companies complement each other and how we can leverage our combined relationships, expertise, and resources to build out our distribution network, enhance syringe safety around the world, and introduce novel drug delivery solutions to the healthcare industry,” said Robert Hayes, Sharps CEO. On February 21, 2024, Sharps Technology. announced that it was preparing to make the first shipment of its 1mL and 3mL Securegard smart safety syringe line to the Latin American healthcare market. Tapping into the growing interest in safety syringe technology in Latin America, the collaboration will make the Securegard syringe line available to hospitals, pharmacies and direct points of sale and will give healthcare networks access to utilizing the technology and firsthand experience with its real-world benefits. “We are building strategic partnerships within the entire Latin American distribution network to support region-wide efforts to improve medical safety and healthcare outcomes. While implementing wide-scale change can be challenging, we are well positioned to introduce Securegard to healthcare agencies and facilities across the region,” comments Robert Hayes, Sharps Technology CEO. “Based on prior studies, we are confident that once healthcare practitioners use Securegard syringes, they will want to continue to use them in their practice, leading to ongoing purchase orders.” Securegard syringes provide clinicians with an ultra-low waste drug delivery technology that incorporates active safety features as well as World Health Organization-accredited reuse prevention measures. These features maximize the amount of drug therapy that is available to patients while both protecting frontline healthcare workers from life-threatening needle stick injuries and protecting the public from the dangers of needle reuse. Securegard syringes offer a promising drug delivery solution for healthcare markets, facilities and providers by incorporating safety and reuse prevention features into their design. Moreover, the use of ultra-low waste syringe technology ensures that the maximum number of doses of needed drug therapies can be made available to the people who depend on them. On March 7, 2024, Sharps Technology and Roncadelle Operations signed a sales and distribution agreement to cooperatively sell and distribute each other’s products to their respective areas of influence. The agreement lays the groundwork for further collaboration between Sharps and Roncadelle to develop and manufacture next-generation drug delivery products. “We believe that this is just the beginning of Sharps’ collaboration with Roncadelle. It expands our footprint as a premier manufacturer and a distributor of smart safety syringes as well as a collaborative leader in the development of drug delivery systems for the world market,” commented Sharps Technology CEO Robert Hayes. “Sharing our product portfolio gives healthcare customers one-stop access to a broad range of delivery solutions and price points to match their needs and strictest requirements.” As part of the cooperative agreement, Sharps and Roncadelle intend to collaborate on the development of new drug delivery products. The need for innovative injection solutions is expected to grow over the next several years as injectables are the first choice for therapies as diverse as vaccines, biologics, weight loss and maintenance, ophthalmics, gene therapies and diabetes management. The collaboration between Sharps and Roncadelle potentially creates a very important player in advancing these market opportunities through the development of technologies such as prefilled syringes, needle guard systems, auto-injectors and injector pen devices. In light of the recent FDA safety communications concerning the use of syringes manufactured in China, the company believes that the market for safer syringes produced in the U.S. and Europe will grow at an accelerated rate. Featured photo by LookerStudio on Shutterstock. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

April 03, 2024 08:30 AM Eastern Daylight Time

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Accelerating New Molecule Discovery: Rakovina Therapeutics AI Integration

Rakovina Therapeutics Inc

Rakovina Therapeutics President and Chief Science Officer Mads Daugaard and Dr. Art Cherkasov from the Vancouver Prostate Centre and UBC joined Steve Darling from Proactive to unveil an exciting collaboration agreement between Rakovina and Dr. Artem Cherkasov, granting exclusive access to the proprietary Deep Docking AI Platform for DNA-damage response targets. Dr. Cherkasov, who was appointed to Rakovina's scientific advisory board in November 2023, brings unparalleled expertise to the table. The collaboration aims to leverage the cutting-edge capabilities of the Deep Docking AI Platform, powered by advanced AI algorithms, to revolutionize the discovery and development of targeted cancer drugs. By harnessing the power of AI-driven molecular analysis, Rakovina can rapidly evaluate billions of molecular structures to identify potential candidates for targeted cancer therapy. This innovative approach enables the team to focus on DNA-damage response-related vulnerabilities, which are prevalent across various types of cancer. The Deep Docking AI Platform plays a pivotal role in this process, facilitating the rapid screening of billions of drug candidates against validated DNA-damage response targets. Through predictive modeling, the platform can assess safety, efficacy, and pharmaceutical properties, enabling Rakovina to prioritize the most promising candidates for further validation. With access to the Deep Docking AI Platform, Rakovina can expedite the drug discovery process, accelerating the transition from preclinical research to human clinical trials and potential pharmaceutical partnerships. By combining AI-driven molecular analysis with established R&D infrastructure, Rakovina aims to spearhead the development of innovative therapies that target critical vulnerabilities in cancer cells. This collaboration underscores Rakovina's commitment to advancing precision medicine and delivering groundbreaking therapies to patients in need. With the support of Dr. Cherkasov and the cutting-edge capabilities of the Deep Docking AI Platform, Rakovina is poised to make significant strides in the fight against cancer, offering hope to millions of individuals affected by this devastating disease. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

April 02, 2024 12:49 PM Eastern Daylight Time

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Cloud DX Achieves nearly 100 % Contract Renewals worth 1.5 million in revenue

Cloud DX

Cloud DX CEO Robert Kaul joined Steve Darling from Proactive to unveil some exciting developments as the company aims for a 100% renewal rate among its clients whose contracts are expiring in the first quarter of 2024. As of the current date, 11 out of 14 potential renewals have been secured, with the remaining 3 expected to follow suit. Cloud DX specializes in executing contracts with various healthcare providers, offering Connected Health Kits that include approved medical devices and customized tablet computers. These kits are prescribed to patients for chronic care management, post-surgical recovery, remote rehabilitation, or palliative care purposes. Kaul highlighted the diverse range of clients renewing their contracts in the first quarter, including Canadian hospitals, primary care clinics in Alberta, family health teams in Ontario, community paramedic services in Ontario, the Canadian Lung Health Foundation, and a Canadian Provincial health ministry. These clients collectively enrolled approximately 2,900 unique patients in 2023. With the renewal of these contracts, Cloud DX has received orders for Connected Health Kits valued at $96,000 CAD.Furthermore, recurring subscription revenues from these contracts are projected to increase to $575,000 CAD per year, amounting to a total contract value of $1.5 million CAD by December 31, 2025. It's worth noting that Cloud DX maintains a robust gross margin of approximately 77%, as indicated in the company's most recent Financial Statements. Overall, these developments underscore Cloud DX's commitment to advancing healthcare through innovative technology solutions, while also solidifying its position as a leader in the industry. Contact Details Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

April 02, 2024 12:46 PM Eastern Daylight Time

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9 Home Remedies Backed by Science

Spark Metro

Many Home remedies are available to address a range of issues including colds, inflammation, and pain. While not all of these remedies are backed by scientific research, some have garnered support from scientists indicating their potential effectiveness. You've likely experimented with a home remedy before, whether it involved herbal teas for a cold, essential oils for a headache, or natural supplements for better sleep. Perhaps you heard about it from your grandma or stumbled upon it online. Regardless, you gave it a shot, and now you're contemplating its efficacy. The exact mechanism behind why home remedies work remains unclear. Is it due to a physiological change in the body, or is it simply the placebo effect at play? Fortunately, in recent years, scientists have delved into these questions within the confines of a laboratory. Their findings suggest that many of our traditional plant-based remedies hold genuine therapeutic value beyond mere folklore. So, for the skeptics seeking evidence beyond the power of suggestion, rest assured, there's scientific backing to validate the effectiveness of certain home remedies. Here are 9 Home Remedies Backed by Science: Turmeric for Pain and Inflammation: Turmeric, a golden spice used in Ayurvedic medicine for centuries, contains an active compound called curcumin. Research suggests that curcumin is effective in treating pain associated with inflammation. For example: A study found that curcumin was more effective in reducing arthritis pain than an anti-inflammatory drug called diclofenac sodium. Turmeric extract was as effective as ibuprofen in treating pain related to knee osteoarthritis. To benefit from turmeric, consider taking curcumin supplements (about 2 to 5 grams per day) along with a pinch of black pepper to enhance absorption Chili Peppers for Pain and Soreness: Capsaicin, the active component in chili peppers, has a long history in folk medicine. It’s now widely accepted for managing pain. Capsaicin works by causing a warming sensation on the skin, followed by numbness. You can find prescription capsaicin patches (like Qutenza) that contain a high concentration of capsaicin (8 percent) for pain relief. If you have sore muscles or generalized body pain, consider using hot peppers or cayenne pepper topically. Ginger: Ginger has anti-inflammatory properties and may help with nausea, especially during pregnancy or after surgery. You can consume ginger as a tea, in cooking, or take ginger supplements. Shiitake Mushrooms: Shiitake mushrooms contain compounds that support the immune system and may have antiviral properties. Incorporate shiitake mushrooms into your diet for overall health. Eucalyptus: Eucalyptus oil is commonly used for respiratory issues. It may help relieve symptoms of colds and congestion. Use eucalyptus oil in a diffuser or as a chest rub. Lavender: Lavender essential oil is known for its calming effects. It may help reduce anxiety and improve sleep quality. Use lavender oil in a diffuser or add a few drops to your bath. Mint: Peppermint oil can alleviate symptoms of irritable bowel syndrome (IBS), including bloating and abdominal pain. Consider using peppermint oil capsules or drinking peppermint tea. Fenugreek: Fenugreek seeds may help regulate blood sugar levels and improve insulin sensitivity. Soak fenugreek seeds overnight and consume them in the morning. Magnesium: Magnesium supplements can help with muscle cramps, migraines, and sleep disturbances. Consult a healthcare professional before starting magnesium supplementation. Remember that while these remedies have scientific support, individual responses may vary. Always consult with a healthcare provider before trying any new remedy or supplement. What other natural remedies can I try? Here are some additional natural remedies you can explore: Honey and Lemon for Sore Throats: Mix warm water with honey and a squeeze of lemon. Gargle this solution to soothe a sore throat. Honey has antimicrobial properties, and lemon provides vitamin C. Apple Cider Vinegar for Digestive Issues: Dilute apple cider vinegar in water and drink it before meals. It may help with digestion, bloating, and acid reflux. Peppermint Tea for Digestive Discomfort: Peppermint tea can ease indigestion, bloating, and gas. It also has a calming effect on the stomach. Chamomile Tea for Sleep and Anxiety: Chamomile tea is known for its calming properties. It can help with anxiety and promote better sleep. Garlic for Immune Support: Garlic contains compounds that boost the immune system. Incorporate fresh garlic into your meals. Aloe Vera for Skin Irritations: Aloe vera gel can soothe sunburns, minor cuts, and skin irritations. Apply it topically. Cranberry Juice for Urinary Tract Health: Cranberry juice may help prevent urinary tract infections by preventing bacteria from adhering to the bladder wall. Oatmeal Baths for Itchy Skin: Add colloidal oatmeal to your bathwater to relieve itchy skin caused by conditions like eczema or insect bites. Ginger Tea for Nausea: Ginger tea or ginger candies can alleviate nausea, especially during pregnancy or motion sickness. Epsom Salt Baths for Muscle Relaxation: Dissolve Epsom salt in warm water and soak to relax sore muscles and reduce inflammation. Remember that individual responses may vary, and it’s essential to consult with a healthcare provider before trying any new remedy. What are some natural remedies for headaches? Here are natural remedies that you can try to alleviate headaches: Drink Water: Hydration is crucial. Dehydration can trigger headaches, so make sure to drink enough water throughout the day. Water-rich foods like fruits and vegetables also contribute to hydration. Magnesium: Magnesium deficiency has been linked to frequent migraines. Consider taking magnesium supplements or consuming magnesium-rich foods. Apply Cold Compress: Place a cold compress on your forehead or the back of your neck. Cold temperatures can help reduce inflammation and ease headache discomfort. Ginger Tea: Ginger has anti-inflammatory properties and may relieve nausea associated with headaches. Brew ginger tea or chew on ginger candies. Peppermint Oil: Peppermint oil applied to your temples or massaged onto your forehead can provide relief from tension headaches. Lavender Oil: Inhaling lavender essential oil can promote relaxation and reduce headache intensity. Use it in a diffuser or add a few drops to your bath. Stay Consistent with Meals: Skipping meals can trigger headaches. Maintain regular eating patterns and avoid extreme hunger or undereating. Limit Caffeine Intake: While caffeine can sometimes help with headaches, excessive consumption or sudden withdrawal can worsen them.Find a balance that works for you. Practice Relaxation Techniques: Techniques like deep breathing, meditation, and progressive muscle relaxation can reduce stress and prevent tension headaches. Get Adequate Sleep: Lack of sleep can contribute to headaches. Prioritize quality sleep to support overall well-being. What are some acupressure points for headaches? Acupressure involves stimulating specific pressure points on the body to alleviate headaches. While scientific evidence is limited, some people find relief through these techniques. Here are a few acupressure points to try: Third Eye (GV 24.5): Locate the third eye pressure point between your eyebrows, slightly above the bridge of your nose. Apply gentle pressure or massage it in a circular motion. This point is believed to help with headache relief. Back of the Head (Occiput): There are two points on the back of the head (occiput) that can relieve tension headaches. Apply pressure to these points to ease discomfort. Neck-Shoulder Junction: Focus on the area where your neck meets your shoulders. Massage this junction to release tension and reduce headache symptoms. Hands: The hands contain several acupressure points that may help with headaches. Explore the webbing between your thumb and index finger (known as Hegu or LI4 ). Apply pressure here to potentially alleviate headaches. Tell me more about acupressure for other conditions. Acupressure is a traditional Chinese therapy that involves stimulating specific pressure points on the body. While scientific evidence varies, many people find relief from various conditions through acupressure. Here are some areas where it may be beneficial: Insomnia: Acupressure can help manage sleep disturbances and promote better rest. Stress Management: Certain pressure points may alleviate stress and induce relaxation. Headaches: Massaging specific points can ease tension headaches and migraines. Menstrual Cramps: Acupressure may provide relief from menstrual discomfort. Motion Sickness: Applying pressure to specific points may reduce symptoms of motion sickness. Muscle Tension and Pain: Acupressure can target muscle knots and tension. Nausea and Vomiting During Pregnancy (Morning Sickness): Some pregnant individuals find relief through acupressure. Cancer Treatment Side Effects: Acupressure may help manage side effects of cancer treatments. Immune System Problems: It’s believed that acupressure can positively influence immune function. Infertility: While not a standalone treatment, acupressure may complement fertility therapies. Irritable Bowel Syndrome (IBS): Some individuals with IBS report symptom improvement with acupressure. Menopause and Hot Flashes: Acupressure might help manage menopausal symptoms. Pregnancy Discomforts: From back pain to nausea, acupressure may offer relief during pregnancy. Repetitive Strain Disorders and Overuse Syndrome: Acupressure could be part of a holistic approach to managing these conditions. How can I use acupressure for stress relief? Certainly! Acupressure is a natural technique that involves stimulating specific pressure points on your body to promote relaxation, reduce stress, and improve overall well-being. Here are some acupressure points you can try for stress relief: Hall of Impression Point: Located between your eyebrows, this point is said to help with both anxiety and stress. To use this point: Sit comfortably and close your eyes. Touch the spot between your eyebrows with your index finger or thumb. Take slow, deep breaths and apply gentle, firm pressure in a circular motion for 5 to 10 minutes. Heavenly Gate Point: Found in the upper shell of your ear, at the tip of the triangle-like hollow. Stimulating this point may relieve anxiety, stress, and insomnia. To use this point: Locate it in your ear (a mirror might help). Apply firm, gentle pressure in a circular motion for two minutes. Shoulder Well Point: Located in your shoulder muscle. To find it, pinch your shoulder muscle with your middle finger and thumb. This point helps with relieving stress, muscle tension, and headaches. Avoid using this point if you’re pregnant, as it can also induce labor. To use this point: Pinch the muscle with your thumb and middle finger. Apply gentle, firm pressure with your index finger and massage the point for four to five seconds. Union Valley Point: Found in the webbing between your thumb and index finger. Stimulating this point is said to reduce stress, headaches, and neck pain. Like the shoulder well point, avoid it during pregnancy. To use this point: With your index finger and thumb, apply firm pressure to the webbing between the thumb and index finger of your other hand. Final words on 9 Home Remedies Backed by Science In conclusion, these home remedies offer promising natural alternatives supported by scientific research for various health concerns. Turmeric's curcumin, capsaicin from chili peppers, and ginger showcase anti-inflammatory properties, while shiitake mushrooms and fenugreek contribute to immune health and blood sugar regulation, respectively. Essential oils like eucalyptus and lavender offer respiratory and calming benefits. Incorporating these remedies into daily routines, such as in teas or topical applications, can provide significant relief. Additionally, considering alternative remedies like honey and lemon for sore throats or apple cider vinegar for digestive issues broadens the spectrum of natural solutions available. For headache relief, acupressure presents an intriguing avenue, targeting specific pressure points linked to tension and migraine headaches. However, individual responses may vary, emphasizing the importance of consulting healthcare professionals before integrating these remedies. With a holistic approach, leveraging these home remedies alongside conventional treatments can empower individuals to manage their health effectively and naturally. Contact Details Medicoworlds Alex +1 302-597-6768 Apexreviews154@gmail.com Company Website https://medicoworlds.com/

March 30, 2024 06:28 AM Eastern Daylight Time

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The Next Wave Of AI? How Hailo’s Edge AI Chips May Help Transform The Industry

OurCrowd

By Meg Flippin, Benzinga Artificial intelligence is no longer restricted to big data centers, crunching complex data sets to help businesses increase productivity and improve processes. It is becoming ubiquitous as more use cases for this transformative technology emerge. One only has to look to Microsoft Corp.’s (NASDAQ: MSFT) Copilot and OpenAI’s ChatGPT for evidence. Relying on a large language model, the chatbots enable users to research and write content in seconds. That’s just one example of how AI is becoming more mainstream. “We’re in the IBM mainframe era of AI, with the giant data centers representing a few giant computers that dominated the scene during the mainframe era,” George Gilder, the well-known investment advisor who has often been ahead of trends and predicted the world would shift to a decentralized model, said during a webinar for the community and the Gilder Private Reserve subscribers. “I think AI is going to be in every smartphone and every pocket, and it's going to be distributed through the Internet of Things. It's going to be ubiquitous. It's really a new IO for the new technology platform of the age.” Hailo Sits On The Edge That shift to decentralized AI where it no longer lives in the cloud or isolated in a data center, but rather on the edge, is where Hailo, the Israeli semiconductor startup, is operating. It sees a big opportunity for newcomers like itself to take advantage of the natural progression of AI. “AI is learning from examples, contrary to plastic computers which are just being given a very specific set of rules. It’s kind of intuition versus logic,” Orr Danon, CEO at Hailo, said during an interview portion of the webinar with John Schroeder of the Gilder Private Reserve. “It’s a huge pivot in the kind of technology you need to implement this. It’s an opportunity for a new player to come and emerge and take a significant market share. And that's exactly what we are doing in the company.” It is a big and growing market opportunity. Danon said the global chip market is about $600 billion today and is projected to cross the $1 trillion per annum mark at the end of the decade. Hailo makes AI vision processors and AI accelerator chips designed to accelerate embedded deep learning applications on edge devices. The company’s chips can be embedded in a variety of devices including autonomous vehicles, personal computers, smart cameras, robotics, industrial machinery, healthcare devices, drones and home appliances. Hailo Does It Cheaper While big chip companies like Nvidia Corp. (NASDAQ: NVDA) are focusing on making AI chips for data centers and cloud computing, Hailo is seeing growing demand for AI chips that sit on the edge, processing the data locally for use with everything from in a variety of devices including autonomous vehicles, personal computers, smart cameras, robotics, industrial machinery, healthcare devices and drones. Hailo says its chips are cheaper, more efficient and only require a few watts for power consumption. In comparison Nvidia's chip requires up to hundreds of watts, Hailo said. “The apps that you run are local. Of course, you use data that is connected to the cloud, but the majority of data crunching is being done locally. And that's exactly what we believe in,” said Danon. “This is very beneficial in terms of power consumption of the communication requirements. If you're doing anything that requires a response quickly, like a car moving and needing to understand what's going on around it, you have to be local.” That means someday these edge AI chips will be able to make everyday devices even smarter whether it is a high-definition camera or a vacuum cleaner. Are you looking for an AI investment that won’t cost a fortune? Check out what the founders of Hailo are doing to revolutionize this transformative technology here. Cloud Will Always Have Its Role That’s not to say there won’t be a need for the cloud when it comes to AI, it’s rather that they will complement each other and evolve. For example, cloud and big data centers will always be needed to train the AI, but when it comes to processing or performing the tasks the AI was trained to do, Hailo believes it will happen locally or on the edge. Danon said since the company launched in 2017, Hailo has seen the majority of AI deployments occurring outside of data centers – and that’s also happening with large language models like ChatGPT. “Over the past few years, we've seen the first wave of AI, which is based on fundamentally machine learning models trained by massive amounts of data,” said Danon. “But now we're seeing the second wave emerge. And that is, generative AI, which we are seeing in things like ChatGPT.” AI is in its infancy, but it’s quickly moving outside of the big data center and into the devices we use every day. That presents a big opportunity for chip makers catering to this area of the market including Hailo. Interested in getting in on a startup before the second wave of AI takes off? Click here. Featured photo courtesy of Hailo. OurCrowd was started in 2013, driven by the idea that the business of building startups grows bigger and better when the global ‘crowd’ gains access to VC-level investment opportunities.Today, OurCrowd is a global venture and alternative investing platform that empowers institutions and individuals to invest and engage in emerging companies. OurCrowd vets and selects companies, invests its capital, and provides its global network with unparalleled access to co-invest and contribute connections, talent and deal flow. OurCrowd builds value for its portfolio companies throughout their lifecycles, providing mentorship, recruiting industry advisors, navigating follow-on rounds and creating growth opportunities through its network of multinational partnerships. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Lisa Graston lisa.graston@ourcrowd.com Company Website http://www.ourcrowd.com

March 28, 2024 08:45 AM Eastern Daylight Time

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Algernon Pharmaceuticals Strikes Deal to Advance Ifenprodil in Chronic Cough Treatment

Algernon Pharmaceuticals Inc.

Algernon Pharmaceuticals CEO Christopher Moreau joined Steve Darling from Proactive to announce a significant agreement regarding the company's drug, Ifenprodil with U.S. Based Seyltx. Originally discovered in Japan and not utilized in the US or Europe, Ifenprodil was initially developed to treat intermittent claudication but found application in Japan for vertigo post-stroke. Dr. Mark Williams, Algernon's co-founder, identified Ifenprodil's potential for repurposing in new markets, particularly for Idiopathic Pulmonary Fibrosis (IPF) and chronic cough, a symptom associated with IPF. During the interview, Moreau disclosed that the company has entered into a transformative agreement with a private US firm, granting them rights to advance Ifenprodil through a Phase 2b study targeting chronic cough. This agreement provides Algernon with a 20% interest in the acquiring company and a $2 million U.S. cash infusion. This financial injection strengthens Algernon's financial position and enables it to focus on other projects, including a promising study on DMT for stroke treatment. The agreement represents a pivotal moment for Algernon, positioning Ifenprodil for further development in a market with significant potential. Moreover, it allows Algernon to concentrate on advancing its broader drug development pipeline, ensuring the company remains at the forefront of innovation in the pharmaceutical industry. In summary, the agreement concerning Ifenprodil marks a significant milestone for Algernon Pharmaceuticals, underscoring its commitment to advancing novel treatments and maximizing shareholder value. With a strengthened financial position and a focus on strategic initiatives, Algernon is well-positioned for future growth and success in the competitive pharmaceutical landscape. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

March 28, 2024 08:40 AM Eastern Daylight Time

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