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Amendment to Terms of Acquisition of Synergy Aviation Ltd.

Volatus Aerospace Corp.

This notice is an amendment to the announcement released on October 13, 2022, to include additional information relating to Synergy shareholders' option to convert remaining Synergy shares to Volatus equity. The option of the Synergy shareholders to sell the remaining 49% equity in 2024 after meeting minimum operational and financial metrics will be at the same valuation at Closing and in exchange for Volatus shares based on 30 days VWAP (volume weighted average price) on date of Closing with a minimum floor price of $0.65 per share. The total maximum cash value of the shares if all shareholder shares are converted will be $2,205,000. " This amendment illustrates the confidence of Synergy shareholders in the long-term value of Volatus Aerospace, " said Abhinav Singhvi, CFO of Volatus Aerospace. “This addition in our definitive agreement eliminates significant dilution based on current share price and protects the interest of our existing shareholders.” Full amended news release is attached below: Volatus Aerospace Adds Over 500,000 km of Oil & Gas PipelineRight of Way Surveillance with Acquisition of Synergy Aviation Ltd. Volatus Aerospace Corp. (TSXV:VOL) (OTCQB: VLTTF) ("Volatus" or "the Company") announced on October 13, 2022 that it has signed an arm's length definitive agreement dated Oct 12, 2022, to acquire Alberta-based Synergy Aviation Ltd. This acquisition will solidify Volatus’ position in Western Canada providing privileged access to much of the oil and gas industry. Synergy’s leadership in the sector combined with Volatus’ drone technology solutions will positionthe Company with a strong competitive advantage to introduce innovative, efficient, green, remotely operated drone solutions to fulfill regulatory and asset monitoring requirements. Founded in Alberta in 2014, SynergyAviation is an industry leaderin aerial surveillance, pipeline integrity monitoring, and specialized geomatics, patrolling and inspecting more than 500,000 KM of pipeline right of way stretching from the coast of British Columbia to the Manitoba/US border. The company provides Canada’s largest oil & gas producers and pipeline operators with uninterrupted, consistent and highly detailed right-of-way integrity data. “Pipeline inspection, much like other long linear inspection requirements, has traditionally been completed using crewed helicopters and small fixed wing aircraft,” said Glen Lynch, CEO of Volatus Aerospace. “Leveraging Synergy’s oil & gas presence combined with our existing pipeline operations in Ontario will allow us to introduce the power of innovative drone solutions to meet regulatory compliance and asset management requirements with improved efficiencies and a material reduction in greenhouse gas emissions.” There are nearly 5 million kilometers of oil & gas pipelinein North America requiring annual inspections and, in many cases, weekly patrols to meet regulatory and asset management requirements,” said Todd Tkach,President of SynergyAviation. “Becoming part of Volatusgives us the added geomatics capabilities, market reach, and the opportunity to disrupt traditional methods in this sector. Synergy recorded unaudited revenues of $7 million with a 14% EBITDA (Earnings before Interest, tax, depreciation, and amortization) during the first nine months of 2022 and is targeting year end revenuesof $9 million. Under the terms of the agreement, Volatus will make an equity investment of $2.29 million in Synergy Aviation over the course of 10 months from closing in exchange for newly issued shares that will represent 51% of all outstanding shares. The investment will be used by Synergy for ongoing expansion activities. The transaction is scheduled to close on October 31 st conditional on satisfactory completion of due diligence, approval of the respective Board of Directors, and regulatory approval by the TSX Venture Exchange. Subject to operational and financial metric as defined in the definitive agreement, the Synergyinvestors will have an option,expiring in December2024, to sell the remaining 49% equity to Volatus at the same valuation at Closing in exchange of Volatus shares based on 30 days VWAP (volume weighted average price) on date of Closing with a minimum floor price of $0.65 per share and maximum. The total maximum cash value of the shares if all shareholder shares are converted will be$2,205,000. This announcement marks another step in a series of interrelated technology, regulatory, and commercial milestones intended to drive and scale the commercialization of drone technologies. Recent announcements include the launch of the Aerieport drone nesting station, regulatory authority to remotely operate a drone at an airport, the remote operation of drones in Las Vegas from our operations center 3,000 km away, and most recently, a collaboration agreement with Accipiter Radar to provide for larger scale deconfliction between drones and low flying aircraft. The combination of these events with other Volatus technologies provides large scale opportunities in oil and gas, power distribution, and rail throughout the markets served by Volatus. About Volatus Aerospace: Volatus Aerospace Corp. is a leading provider of integrated drone solutions throughout North America and growing into Latin America and globally. Volatus serves civil, public safety, and defense markets with imaging and inspection, security and surveillance, equipment sales and support, training, as well as R&D, design, and manufacturing. Through our subsidiary, Volatus Aviation, we are introducing green and innovative drone solutions to supplement and replace traditional aircraft and helicopters for long-linear inspections such as pipeline, energy, rail, and cargo services. Volatus is committed to carbon neutrality; the fostering of a safe, equitable and inclusive workplace; and responsible governance. Forward-Looking Information This news release contains statements that constitute “forward-looking information” and “forward-looking statements” within the meaning of applicable securities laws, including statements regarding the plans, intentions, beliefs, and current expectations of the Company with respect to future business activities and operating performance. Often, but not always, forward-looking information and forward-looking statements can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or variations (including negative variations) of such words and phrases, or statements formed in the future tense or indicating that certain actions, events or results “may”, “could”, “would”, “might” or “will” (or other variations of the foregoing) be taken, occur, be achieved, or come to pass. Forward-looking information includes information regarding: (i) the business plans and expectations of the Company; and (ii) expectations for other economic, business, and/or competitive factors. Forward-looking information is based on currently available competitive, financial, and economic data and operating plans, strategies, or beliefs as of the date of this news release, but involve known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information. Such factors may be based on information currently available to the Company, including information obtained from third-party industry analysts and other third-party sources, and are based on management’s current expectations or beliefs. Any and all forward-looking information contained in this news release is expressly qualified by this cautionary statement. Investors are cautioned that forward-looking information is not based on historical facts but instead reflects expectations, estimates or projections concerning future results or events based on the opinions, assumptions and estimates of management considered reasonable at the date the statements are made. Forward-looking information and forward-looking statements reflect the Company’s current beliefs and is based on information currently available to it and on assumptions it believes to be not unreasonable in light of all of the circumstances. In some instances, material factors or assumptions are discussed in this news release in connection with statements containing forward-looking information. Such material factors and assumptions include, but are not limited to: the commercialization of drone flights beyond visual line of sight and potential benefits to the Company; and meeting the continued listing requirements of the TSXV. Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. The forward- looking information contained herein is made as of the date of this news release and, other than as required by law, the Company disclaims any obligation to update any forward-looking information, whether as a result of new information, future events or results or otherwise. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information. Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this news release. Source: Volatus Aerospace Corp. TSXV: VOL Contact Details Abhinav Singhvi +1 514-447-7986 abhinav.singhvi@volatusaerospace.com Company Website https://volatusaerospace.com

October 31, 2022 07:39 AM Eastern Daylight Time

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8 Best "Write My Essay For Me" Websites: Pay Someone To Do It For Cheap

Genuine Papers

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An essay is a form of writing that talks about a specified topic. It could give an overview of the topic or niche-down and discuss sub-topics in such fields. Essays could also relate to taking a side on a given topic. This is usually referred to as an argumentative essay. And here, you approach it from a "for" or "against" perspective. That is, you could argue for such a topic or offer points against it. The other forms of essays include discursive, persuasive, narrative, and descriptive essays. Moreover, one thing is consistent with all these types of essays. And that is a clear outline of thoughts, whether prosaically or argumentatively. Further, most essays are academic. And they are usually regarded as a yardstick for academic performance. Thus, at the middle or end of a teaching term or semester, teachers usually request an essay to test the student's knowledge of the topic taught during that time. And such essays are used as a grading tool for the student's grasp of the topics discussed or taught. Is “do my essay” websites legit to use? “Do my essay” websites are very much legit. They are a safe landing for you when you want to clinch that high grade in your academic pursuits. They are legit because you would not be breaking any law by ordering your essays from them. As a matter of fact, these websites are companies with legally-backed registrations that are government-compliant. Thus, you are safe when you order from them. You do not need to worry about committing any criminal offence when you seek essay assistance from them. Well, simply because you would not be committing any. Also, these websites are legit because they do not offer you plagiarized content as an essay. And alongside, your information is safe with them. So if you are worried about your details leaking on the internet, you should put your mind to rest. This is because they all have a strict anonymity policy where they are discreet with the information of all their customers and clients who place orders on their websites. Is it safe to order college essays online? It is 100% safe to order college essays online. In case you are wondering why, you have to realize that these services are available to assist with your academics. And tons of reviews online would point you to the fact that they are reliable means of getting your essays written. The major reason most customers leave these positive reviews is the level of excellence that accompanies their write-ups. Expert writers on each platform deliver their essays with premium quality—no plagiarism. Rather, you would have access to plagiarism reports upon request. The only moment it becomes unsafe to order college essays online is when you order from unreliable websites. Unfortunately, many sites are posing as original while they are simply fraudulent platforms in disguise looking to scam you. This is why we have a curated list of the best and most trustworthy websites to get your essays written. All you have to do is consider any of them that fits your bill and choose them for your essays. Do professors know if you bought an essay? No. In case you have been wondering, your questions have been answered today. Your professors do not know if you bought an essay. Rather, they are impressed at the excellence of the essay you have submitted. You see, irrespective of your academic level as a high schooler, undergraduate, or even postgraduate, your professors cannot detect that you buy an essay online. Your professor (or any essay detector software like Turnitin, for that matter) cannot detect that you bought an essay online because the essays are original content. The essays written by the "write my essay" websites are written from scratch, and they are with 0% plagiarism. How many students pay for their essays? Don't be surprised that most of the students you know have paid for their essays at one time or the other. It is not a crime to do so. On the contrary, they are absolutely justified to have done so if they ever did. And the reason is that they needed assistance and requested experts' help to write their essays. As a result, most of these students end up topping their classes. And that's because their essays were written by people who have been in their shoes. These specialist writers are academics, and most have bagged postgraduate certifications. Who can write my essay for me? There are many essay writing services online for you to take advantage of. Our 8 best "write my essay for me" websites list to pay someone are reliable online platforms that can write your essays for you. 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October 29, 2022 12:37 AM Eastern Daylight Time

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Volatus Aerospace Corp. to Announce its Q3 2022 Earnings and Host Earnings Call on November 7th

Volatus Aerospace Corp.

Volatus Aerospace Corp. (TSXV: VOL) (OTCQB: VLTTF) ("Volatus" or "the Company"), a global leader in the drone industry, will be announcing its Q3 2022 Earnings on November 7 th before market opening and will host earnings call later that afternoon for investors and stakeholders. Volatus investor relations will host a webinar on Monday, November 7 th at 4:30 PM EST at which time Glen Lynch, Chief Executive Officer, and Abhinav Singhvi, Chief Financial Officer, will review the quarterly results and major milestones with Danielle Gagne, Head of Corporate Communications as moderator. Investors are invited to register for the webinar here. https://us06web.zoom.us/webinar/register/WN_uAeXAvY2SySzMEJf8FIi5g Audio Replay Options An audio replay of the event will be archived on the Investor Relations page of the company's website here. The condensed consolidated interim financial statements for the three months ended September 30 th, 2022, and associated management discussion and analysis, will be available under the Company's profile on SEDAR at www.sedar.com on November 7 th 2022. This news release is not in any way a substitute for reading those financial statements, including the notes to the financial statements. About Volatus Aerospace: Volatus Aerospace Corp. is a leading provider of integrated drone solutions throughout North America and growing into Latin America and globally. Volatus serves civil, public safety, and defense markets with imaging and inspection, security and surveillance, equipment sales and support, training, as well as R&D, design, and manufacturing. Through our subsidiary, Volatus Aviation, we are introducing green and innovative drone solutions to supplement and replace traditional aircraft and helicopters for long-linear inspections such as pipeline, energy, rail, and cargo services. Volatus is committed to carbon neutrality; the fostering of a safe, equitable and inclusive workplace; and responsible governance. Forward-Looking Information This news release contains statements that constitute “forward-looking information” and “forward-looking statements” within the meaning of applicable securities laws, including statements regarding the plans, intentions, beliefs, and current expectations of the Company with respect to future business activities and operating performance. Often, but not always, forward-looking information and forward-looking statements can be identified by the use of words such as “plans”, “expects”, “is expected”, “budget”, “scheduled”, “estimates”, “forecasts”, “intends”, “anticipates”, or “believes” or variations (including negative variations) of such words and phrases, or statements formed in the future tense or indicating that certain actions, events or results “may”, “could”, “would”, “might” or “will” (or other variations of the foregoing) be taken, occur, be achieved, or come to pass. Forward-looking information includes information regarding: (i) the business plans and expectations of the Company; and (ii) expectations for other economic, business, and/or competitive factors. Forward-looking information is based on currently available competitive, financial, and economic data and operating plans, strategies, or beliefs as of the date of this news release, but involve known and unknown risks, uncertainties, assumptions and other factors that may cause the actual results, performance or achievements of the Company to be materially different from any future results, performance or achievements expressed or implied by the forward-looking information. Such factors may be based on information currently available to the Company, including information obtained from third-party industry analysts and other third-party sources, and are based on management’s current expectations or beliefs. Any and all forward-looking information contained in this news release is expressly qualified by this cautionary statement. Investors are cautioned that forward-looking information is not based on historical facts but instead reflects expectations, estimates or projections concerning future results or events based on the opinions, assumptions and estimates of management considered reasonable at the date the statements are made. Forward-looking information and forward-looking statements reflect the Company’s current beliefs and is based on information currently available to it and on assumptions it believes to be not unreasonable in light of all of the circumstances. In some instances, material factors or assumptions are discussed in this news release in connection with statements containing forward-looking information. Such material factors and assumptions include, but are not limited to: the commercialization of drone flights beyond visual line of sight and potential benefits to the Company; and meeting the continued listing requirements of the TSXV. Although the Company has attempted to identify important factors that could cause actual actions, events or results to differ materially from those described in forward-looking information, there may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended. The forward- looking information contained herein is made as of the date of this news release and, other than as required by law, the Company disclaims any obligation to update any forward-looking information, whether as a result of new information, future events or results or otherwise. There can be no assurance that forward-looking information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information. Neither the TSXV nor its Regulation Services Provider (as that term is defined in the policies of the TSXV) accepts responsibility for the adequacy or accuracy of this news release. Source: Volatus Aerospace Corp. TSXV: VOL Contact Details Abhinav Singhvi +1 514-447-7986 abhinav.singhvi@volatusaerospace.com Company Website https://volatusaerospace.com

October 28, 2022 01:45 PM Eastern Daylight Time

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Comcast California Hosts Inaugural Digital Equity Summit in San Francisco

Comcast California

Today, Comcast hosted a Digital Equity Summit in San Francisco. The gathering brought together more than 100 executives, program directors, community leaders, public officials, and other key stakeholders from around the Golden State working to close the digital divide and create digital equity. The goals of the summit were to highlight best practices; learn more about the current and future needs of vulnerable communities; and identify challenges, solutions, and available funding resources. The summit also served as a moment to celebrate the work of Comcast’s valued digital equity partners across California, who worked throughout the pandemic to help drive Internet adoption and provide digital literacy training for those in need. In addition, the company announced it has exceeded its expanded goal to launch 1,250 Lift Zones before the end of this year. Comcast’s award-winning Lift Zones program provides free WiFi access in neighborhood community centers nationwide. Since September 2020, Lift Zones have enabled nearly 6 million free WiFi user sessions for students, veterans, seniors, and adults. According to a consumer survey of users who visited a Lift Zone: 4 in 10 report they would not have had Internet access without the Lift Zone. 50% of low-income households in major Comcast markets are within walking distance of a Lift Zone. 58% of Lift Zone users strongly believe that the site helps them achieve more. 58% report the Lift Zone reduces stress with studying, working remotely, and/or managing tasks online. 56% say the Lift Zone is critical for success at school, work, and/or managing tasks online. 92 percent of sites report that being a Lift Zone helps them increase digital equity in their communities. The Lift Zones program is part of Comcast’s Project UP – a comprehensive initiative to advance digital equity and build a future of unlimited possibilities. Backed by a $1 billion commitment, Project UP will help reach tens of millions of people with the skills, resources, and opportunities needed to succeed in a digital world. “We have a once-in-a-generation opportunity right now to help connect the unconnected,” said Broderick Johnson, EVP of Digital Equity and EVP of Public Policy, Comcast Corporation. “Working together between Comcast, our nonprofit partners, and the state and federal government, we will connect more households to the Internet and help even more people take advantage of critical resources such as the federal Affordable Connectivity Program and digital skills training.” “Comcast’s continued partnership and dedication to our communities have resulted in allowing more students, children, seniors, and families to get connected to the Internet, “said San Francisco Mayor London Breed. “Public-private partnerships like these allow us to ensure that all of our communities have access to services they need to thrive.” Comcast’s Lift Zones were initially created in partnership with city leaders and nonprofit partners to help keep students connected to schools during the early stages of the pandemic. These digital navigators helped countless communities at a time when they needed it the most. Even as students return to their classrooms, Comcast continues to see strong demand for Lift Zones that serve underrepresented populations and offer an array of digital literacy programs, access to online healthcare services, workforce development training, and digital navigator support. “Thanks to Comcast, we’ve been able to connect many of our families to the Internet with high-speed WiFi to support a dynamic learning environment for their children,” said Gloria Corral, President, and CEO of Parent Institute for Quality Education. “Today’s Digital Equity Summit confirms Comcast’s commitment to the communities we serve. I am eager to see how today’s conversation will improve and help support the lives of the children and families.” In addition to the Lift Zone program, which earlier this year won SXSW’s “ People’s Choice Award,” Comcast is proud to participate in the Federal Government’s Affordable Connectivity Program (ACP). ACP provides eligible households with a $30/month subsidy that can be applied toward their Internet service. When used to pay for Comcast’s Internet Essentials service, home broadband Internet is effectively free. Powered by a Comcast Business solution, the company has installed more than 150 Lift Zones across the state of California. To find a Lift Zone near you, please visit: https://internetessentials.com/learningsearchpage and for additional information on Project UP, please visit corporate.comcast.com/impact/project-up. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on connectivity, aggregation, and streaming with 57 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Jon Koriel +1 925-315-2690 jon_koriel@comcast.com

October 28, 2022 10:28 AM Pacific Daylight Time

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Comcast Donates 200+ Laptops to San Joaquin Valley Students and Launches Five New ‘Lift Zones’ to Help Close the Digital Divide

Comcast California

In an effort to help close the Digital Divide in California, Comcast today donated 200+ laptops to students at El Concilio Academy in Stockton, CA, while also opening five new Lift Zones at several El Concilio California locations to provide free access to high-speed WiFi. As part of its larger digital equity initiative, Comcast also made a cash contribution of $50,000 to El Concilio, California, which is one of the largest community-based, nonprofit social service providers in California’s San Joaquin and Stanislaus Counties. Comcast’s award-winning Lift Zones program offers free WiFi, powered by a Comcast Business solution, which enables students, seniors, families, and community members to get online and more fully participate in the digital economy. With these new locations, Comcast has now established five Lift Zones in San Joaquin County—and a total of over 150 Lift Zones throughout its California service area. “It’s no secret that having access to high-speed, reliable broadband is even greater today than it was a couple years ago, and I’m grateful to see business partners like Comcast continuing to invest in our underserved communities,” said Jose R. Rodriguez, President & CEO of El Concilio California. “The resources provided by Comcast to our students and families today will have a significant impact on their overall quality of life, help maximize their potential and create lasting change.” “Thank you, Comcast for positively impacting our community through technology services, financial resources, and the launch of new Lift Zones in Stockton.” said Mayor Kevin Lincoln, of Stockton, CA. “Internet access is not a luxury, it is a necessity. I am grateful for Comcast’s continued support in providing these critical tools for our city.” “Closing the digital divide and addressing digital equity remain two of Comcast’s top priorities here in Stockton and across the nation,” said Broderick Johnson, EVP, Digital Equity and EVP, Public Policy, Comcast Corporation. “Programs like Lift Zones and our continued donations to provide digital literacy resources are helping to level the playing field and make sure the Internet is available to everyone who needs it.” Today’s announcement and donation is part of Project UP, Comcast’s $1 billion commitment to reach millions of people with the tools, resources, and skills needed to succeed in a digital world. The Comcast Lift Zones program complements the Internet Essentials program, which since 2011, has helped connect more than 10 million low-income people to the Internet at home. In California, Comcast has connected more than 1.7 million residents, making it the number one state in terms of overall participation in the Internet Essentials program. Comcast continues to be an avid participant in the Federal Government’s Affordable Connectivity Program (ACP), which provides eligible people up to a $30/per month credit toward their Internet and mobile services. New and existing Xfinity Internet or Internet Essentials customers can learn more about the program and sign up by visiting: https://www.xfinity.com/learn/internet-service/acp/free-internet. About El Concilio California Academies: El Concilio California Academies (ECCA) partners with community groups to build and operate free K-12 public charter schools serving students in the California. ECCA’s system of schools is designed to eliminate the achievement gap and provide school choice to families so their children are prepared for success in high school, college, and beyond. For more information or to enroll your student in the new Academy, visit ECCAcademies.org. About El Concilio California: In continual operation for 54 years, El Concilio California is a 501(c)(3) nonprofit multi-service agency with the trusted mission to uplift and advocate for California’s marginalized, minority, economically segregated, and communities of color by providing access to crucial services, programs, and resources to over 75,000 individuals and families annually for a whole-person approach to increased physical, psychological, and economic well-being, to help people create better futures for themselves and their families reach their full potential, become leaders to the community, and in turn empower others. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on connectivity, aggregation, and streaming with 57 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Jon Koriel +1 925-315-2690 jon_koriel@comcast.com

October 27, 2022 04:00 PM Pacific Daylight Time

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Comcast Makes Significant Investments in Fresno, CA to Help Close the Digital Divide

Comcast California

As part of its ongoing commitment to digital equity, workforce development, and work readiness skills, Comcast today announced the launch of a new “Lift Zone” at Saint Rest Baptist Church, surprising 200 families with free laptops, and investing $200,000 to bring digital equity to the Valley. This new Lift Zone will provide free WiFi access, powered by a Comcast Business solution, to help connect youth and their families, seniors, and community members to the Internet so they can fully participate in educational opportunities and the digital economy. With this new location, Comcast has now established 16 Lift Zones in Fresno County—and a total of more than 150 Lift Zones throughout its California service area. Comcast also donated $25,000 to Saint Rest Baptist Church to help create a new computer lab as well as provide digital literacy training to students, families, seniors, and community members within Fresno. Earlier this year, Comcast also invested $1 million to expand its network to Biola, CA, a rural community in Fresno County, along with opening a Lift Zone at the Biola Community Services District. Through these significant investments and supply of reliable WiFi service at multiple educational and community spaces, in addition to homes and businesses, Comcast has helped thousands get online, bringing the Central Valley a step closer to eliminating the digital divide. Additionally, Comcast announced today at an event with tech apprentices a $200,000 investment in Bitwise Impact, a 501(c)(3) to provide paid apprenticeships to learn technology skills and connect to meaningful technology opportunities in the Central Valley. The donation will help these organizations continue their impactful work in Fresno “For years, Comcast has shown its commitment to supporting low-income families and our community by ensuring they have access to an affordable, fast and reliable Internet connection,” said Pastor D.J. Criner, Pastor of Saint Rest Baptist Church. “We’re proud to partner with Comcast on the opening of this Lift Zone and look forward to the positive benefits it will bring to our Saint Rest community.” “Comcast’s significant investment in Fresno will expand workforce development initiatives and shows their commitment to connecting those who have largely been underserved with life changing opportunities in tech,” said Irma Olguin Jr., board member, Bitwise Impact. “Today’s announcement, and continued Comcast support, will increase access to tech training that supports small businesses, creates future leaders and entrepreneurs from individuals who otherwise would not have seen the tech industry as a place for them.” “Our continued partnership with the St. Rest Baptist Church community and Bitwise is part of our constant work here in Fresno, in which we’re striving to advance digital equity and workforce readiness in communities across the Central Valley,” said Broderick Johnson, EVP, Digital Equity and EVP, Public Policy, Comcast Corporation. “The opening of this new Lift Zone and computer lab at St. Rest and our $200,000 donation to Bitwise allows us to support students, seniors and families and provide them with the tools, skills, and resources they need to get connected and achieve their goals.” Today’s announcement and donation is part of Project UP, Comcast’s $1 billion commitment to reach millions of people with the tools, resources, and skills needed to succeed in a digital world. Comcast’s award-winning Lift Zones program complements the Internet Essentials program, which since 2011, has helped connect more than 10 million low-income people to the Internet at home. In California, Comcast has connected more than 1.7 million residents, making it the number one state in terms of overall participation in the Internet Essentials program. Lastly, Comcast continues to be a proud participant in the Federal Government’s Affordable Connectivity Program (ACP), which provides eligible people up to a $30/per month credit toward their Internet and mobile services. New and existing Xfinity Internet or Internet Essentials customers can learn more about the program and sign up by visiting: https://www.xfinity.com/learn/internet-service/acp/free-internet About Bitwise Impact Bitwise Impact, a 501(c)(3) nonprofit, launched in 2022 with the mission of mobilizing resources and communities to uplift underestimated individuals and/or those coming from a story of poverty. Bitwise Impact partners with mission-aligned organizations to unite resources, and connect community activators with the purpose of removing barriers for individuals aspiring for high-growth, high-wage employment in the tech industry. Beyond supporting partners through financial infusions, Bitwise Impact conducts and shares research to better understand demographics served, and systemic issues preventing upward mobility. All of this is done with the goal of building philanthropic alliances to create an equitable society. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on connectivity, aggregation, and streaming with 57 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, multiple cable networks, Peacock, NBCUniversal News Group, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. Contact Details Comcast California Jon Koriel +1 925-315-2690 jon_koriel@comcast.com

October 27, 2022 11:00 AM Pacific Daylight Time

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Elsevier and the American College of Medical Genetics and Genomics Announce the Forthcoming Launch of Genetics in Medicine Open

Elsevier

The American College of Medical Genetics and Genomics (ACMG), the only nationally recognized US medical professional organization solely dedicated to improving health through the practice of medical genetics and genomics, and Elsevier, a global leader in research publishing and information analytics, are delighted to announce the January 2023 launch of a new gold open access, online only journal: Genetics in Medicine Open ( GIM Open ), an Official Journal of the ACMG. GIM Open will complement ACMG’s flagship journal Genetics in Medicine ( GIM ), also published by Elsevier, and is designed to meet the evolving needs of the global medical genetics and genomics community and expand its open access publishing options. Published under Creative Commons license, all GIM Open articles will be immediately, permanently, and openly available online for readers to view, download, share, and reuse. This will enable authors to more easily comply with funder and institutional mandates, even as requirements continue to evolve. ACMG’s decision to expand the breadth of its openly available content directly supports its mission to improve personal and public health through the clinical and laboratory practice of medical genetics; advocacy, education, and clinical research programs; and the safe and effective integration of genetics and genomics into all of medicine and healthcare. “I am excited about our new gold open access journal that will be available to anyone, anytime, anywhere in the world independent of financial resources or library access. GIM Open will be an international journal with a focus on medical genetics and genomic medicine including all aspects of therapy,” noted ACMG retiring Chief Executive Officer Maximilian Muenke, MD, FACMG, who led the development of the new journal. “It will be a trail blazer for diversity, equity, and inclusion from a double anonymous review process of manuscripts, to the Editor-in-Chief and an editorial board that truly reflects our society in the United States and around the world. We are fortunate to work with our colleagues Robert D. Steiner, MD, FAAP, FACMG, and Jan Higgins, PhD, ELS, from GIM and our publisher Elsevier on the start of this new venture. As a medical geneticist who thinks that genomic medicine is the present and future of medicine, GIM Open will educate healthcare professionals to contribute to optimal patient care everywhere.” GIM Open’s eminent international editorial board will be led by Editor-in-Chief Bo Yuan, PhD, FACMG, Baylor College of Medicine, an internationally recognized expert in the field. “I am tremendously honored and excited to serve as the founding editor of this new journal that will actively support open science for the medical, scientific and research professionals in a broad range of specialties who comprise our ACMG community,” said Dr. Yuan. “Collectively, members of the editorial board and I are dedicated to the rapid dissemination of high quality, authoritative and cutting-edge medical genetic knowledge both within and beyond the genetics community with the ultimate goal of improving patient outcomes.” Louise Curtis, Senior Vice President, Life Sciences and Social Sciences, Elsevier, commented, “We are extremely pleased to expand our publishing portfolio with ACMG, building on our collaborative partnership with this prestigious society that began in 2022 with publication of GIM. Launching GIM Open strongly aligns with our mission to help researchers and healthcare professionals advance science and improve health outcomes for the benefit of society, and we share the commitment to inclusion and diversity at the heart of this exciting new venture.” GIM Open manuscript processing will include rigorous double anonymous peer review, a rapid submission to publication decision turnaround time, and an expedited publication timeline. Detailed instructions for authors and information regarding open access and publishing fees can be found here. Manuscript submission will open as of October 25, 2022. Papers submitted to GIM may be considered for publication in GIM Open if deemed more appropriate for that journal. It is Elsevier’s intention to submit GIM Open for inclusion in the major abstracting and indexing services at the earliest opportunity. As one of the fastest-growing open access publishers in the world, nearly all of Elsevier's 2,700 journals enable open access publishing, including 600 fully open access journals. In 2021, Elsevier published 119,000 gold or pay-to-publish open access articles, an increase of more than 46% over 2020, making Elsevier one of the largest open access publishers in the world. Notes for editors About Genetics in Medicine Open ( GIM Open ) Genetics in Medicine Open ( GIM Open ) is an open access journal with a broad focus on medical genetics and genomic medicine including all aspects of therapy. It will have a strong emphasis on diversity, equity, and inclusion and will have a double anonymous review process for submitted manuscripts. Positioned as an official journal of the American College of Medical Genetics and Genomics (ACMG) and the companion journal of Genetics in Medicine, GIM Open aims to be an international journal publishing research studies that advance the knowledge, understanding, and practice of medical genetics and genomic medicine for all continents. GIM Open welcomes submissions of Original Research, Reviews, Commentaries and Brief Reports in the areas of clinical genetics, cytogenetics, molecular genetics, biochemical genetics, reproductive medicine, cancer genetics, pharmacogenomics, clinical trials, population genetics, public health, genome-wide association studies, polygenic risk, bioinformatics, methodologies, clinical implementation, ELSI (ethical, legal and social issues), genetic counseling, and practical standards and guidelines. Manuscripts reporting animal models providing clinically relevant insights into human disease mechanisms and potential therapeutics are also welcome. Manuscripts of candidate disease gene discoveries based on a small cohort size but solidified by a high standard of scientific rigor, validity and reproducibility may be considered. Rare case reports may be considered if they fill a knowledge gap in populations underrepresented in genetics research or experiencing health disparities, or inform exceptionally significant actionability in diagnosis, prognosis, and therapeutics. GIM Open promotes studies that include diverse especially under-represented populations. www.gimopen.org About Elsevier and society partnerships Elsevier has long-standing partnerships with over 600 learned societies worldwide, helping them to realize their missions and inspire and support their communities. We pride ourselves on consistently delivering outstanding publishing outcomes through strategic insight, reliable finances, global dissemination, embracing open science and open access, and championing the needs of the communities we jointly serve. www.elsevier.com/societies About American College of Medical Genetics and Genomics (ACMG) Founded in 1991, the American College of Medical Genetics and Genomics (ACMG) is the only nationally recognized medical professional organization solely dedicated to improving health through the practice of medical genetics and genomics, and the only medical specialty society in the US that represents the full spectrum of medical genetics disciplines in a single organization. The ACMG is the largest membership organization specifically for medical geneticists, providing education, resources and a voice for nearly 2,500 clinical and laboratory geneticists, genetic counselors and other healthcare professionals, nearly 80 percent of whom are board certified in the medical genetics specialties. ACMG’s mission is to improve health through the clinical and laboratory practice of medical genetics as well as through advocacy, education and clinical research, and to guide the safe and effective integration of genetics and genomics into all of medicine and healthcare, resulting in improved personal and public health. www.acmg.net About the Editor-in-Chief Bo Yuan, PhD, FACMG is an Associate Professor of the Human Genome Sequencing Center (HGSC) and the Department of Molecular and Human Genetics at Baylor College of Medicine (BCM). He is also a Division Director of the Clinical Laboratories of HGSC. After receiving his Bachelor’s degree from Nankai University in China, he came to the United States and completed his PhD training in molecular and human genetics at BCM. He then received the American Board of Medical Genetics and Genomics (ABMGG) fellowship at BCM and was subsequently board-certified in Clinical Molecular Genetics and Clinical Cytogenetics. Dr. Yuan is an active laboratory geneticist and academic researcher with interest in characterizing new mechanisms of human genetic disorders, investigating, developing and implementing tools to improve molecular diagnostics and genomic data interpretation, and enhancing the visibility of genomic medicine in clinical care. He has authored and co-authored more than 60 peer-reviewed publications and book chapters. Dr. Yuan is a Fellow of the American College of Medical Genetics and Genomics (ACMG). He is also a contributing member of other professional communities, including the American Society of Human Genetics (ASHG), ClinGen Variant Curation Expert Panel, and ACMG evidence-based guideline (EBG) workgroup. He has also been a longtime reviewer for a number of journals. About Elsevier As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems. In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders. Elsevier employs 8,700 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on our over 2,700 digitized journals, including The Lancet and Cell; our over 43,000 eBook titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. www.elsevier.com Contact Details Elsevier Kiran Dhaliwal - Global Press & Communications Manager newsroom@elsevier.com American College of Medical Genetics and Genomics Kathy Moran - Senior Director, Communications and Public Relations kmoran@acmg.net Company Website https://www.elsevier.com/

October 27, 2022 09:00 AM Eastern Daylight Time

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Robots & Pencils Announces Launch of Student Apps to Simplify and Elevate Learner Success

Robots & Pencils

Today, Robots & Pencils, a digital product company focused on transforming businesses with mobile, web, and frontier technologies, announced the release of its new education product, Student Apps. Concurrently, the company has appointed Ryan Gialames as Head of Product, Edtech, to lead and execute the ongoing strategy and design of Student Apps. Student Apps provides students with a seamless, customized experience that supports each learner’s unique journey. Powered by Salesforce, Student Apps integrates backend systems, including student information systems and learning management system platforms, under a user-centered front end. This multi-app platform is a breakthrough in the educational technology field as its unique method of consolidating all student data eliminates the data silos that normally impede the ability of staff to support students. “Student Apps is designed to meet the needs for institutions focused on providing full support to learners who would like to optimize their existing technological investments, unlock the power of Salesforce and Slack for education, build a journey unique to each learner through automation, connect learners to their community, and deliver innovative programs,” said Tracey Zimmerman, President and CEO of Robots & Pencils. “Our goal is to break current barriers and create new and innovative solutions that meet the needs of our clients in the current digital landscape.” Student Apps has already had a successful trial run with Arizona State University. In 2019, ASU and Robots & Pencils partnered to find a way to streamline ASU’s technology in order to better communicate with students. Robots & Pencils created a Slack bot, now available as part of the Student Apps suite, that helps with the onboarding process and cuts down the amount of manual labor required to get students enrolled and engaged with the institution, driving better student outcomes. “Universities often “ship the org chart”, with each department vying for the learner’s time and attention. Combine this with a landscape of disparate edtech technologies and the student experience suffers. Student Apps solve this problem, providing a set of tools to help learners manage the important tasks and milestones that will support their success and connecting them to those who can help, including staff and peers. ” said Gialames. “I’m thrilled to have the opportunity to work with a forward-thinking company like Robots & Pencils to help universities and professional learning providers solve pressing matters and build the optimal learner experience.” Effective immediately, Gialames has stepped into the role of Head of Product for the company’s education technology. In this role, he will be responsible for launching edtech products, such as Student Apps, and bringing them to market while also driving the future innovation of these products. Most recently Gialames served as the Sr. Director, UX/UI at Western Governors University. Previously, he served as the Director in Product Design at Robots and Pencils where he led product strategy and design across all education clients including Arizona State University, University of Texas, Texas Oncourse, and Trilogy Education which was acquired by 2U. Prior to joining Robots & Pencils, Gialames was the Senior Director of Product Strategy and UX at the Carnegie Mellon University backed edtech startup, Acatar, and was Manager of Online Student Experience at Education Management Corporation. Student Apps is now available in the Salesforce Appexchange. The platform has an annual license fee and implementation service fees, and can be configured to suit the needs of the institution. This rollout follows additional growth across industries for Robots & Pencils, who announced an investment from Salesforce Ventures and the company’s partnership with LunaYou, a women-centered maternal wellbeing program created to address the maternity crisis earlier this year. To learn more about Robots & Pencils, please visit www.robotsandpencils.com About Robots & Pencils: Established in 2009, Robots & Pencils is a digital innovation firm founded on the then-contrarian view that mobile would be more transformative than the Internet. Today, in an age of unprecedented technology acceleration, Robots & Pencils helps companies maintain a competitive advantage by developing new digital strategies and products focused on education, financial services, and retail & consumer goods. For more information, please visit robotsandpencils.com. Contact Details N6A for Robots & Pencils Paige Blair robotsandpencils@n6a.com

October 25, 2022 09:05 AM Eastern Daylight Time

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Hong Kong Baptist University-led research identifies Salvia miltiorrhiza extract as potential preventive agent for gastric cancer induced by bile reflux

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 25 October 2022 - Research led by the School of Chinese Medicine at Hong Kong Baptist University (HKBU) has identified cryptotanshinone, a compound extracted from the Chinese herbal medicine Salvia miltiorrhiza, with the potential for the treatment and prevention of gastric cancer associated with bile reflux. The researchers unveiled the mechanism of how bile reflux induces gastritis and gastric cancer. They explained that refluxed bile acids (BAs) lead to the proliferation of pro-inflammation bacteria that promote gastric carcinogenesis, the formation of cancer. Professor Jia Wei, Associate Dean (International Collaboration) of Chinese Medicine and Cheung On Tak Endowed Professor in Chinese Medicine at HKBU, has identified cryptotanshinone with the potential for the treatment and prevention of gastric cancer associated with bile reflux. The research findings have been published in the international scientific journal Advanced Science. Role of bile reflux in gastric cancer unclear Bile, secreted by the liver, is stored in the gallbladder and is released to the duodenum to help digest fat. When the pylorus connecting the stomach and the duodenum is damaged or fails to work properly, bile in the duodenum can enter the stomach, causing gastritis. People with stomach surgery complications, peptic ulcers or gallbladder removal surgery have higher risks of bile reflux. However, the mechanism of how bile reflux induces gastric carcinogenesis remains unclear. Professor Jia Wei, Associate Dean (International Collaboration) of Chinese Medicine and Cheung On Tak Endowed Professor in Chinese Medicine at HKBU, in collaboration with researchers from Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, conducted a study on how bile reflux induces gastric carcinogenesis, and looked for new prevention and therapeutic approaches. Professor Jia said: “We unveiled for the first time the underlying mechanism by which bile reflux promoted the development of gastric carcinogenesis. It offers important clinical insights on the development of novel prevention and therapeutic approaches for the disease. Based on the newly discovered mechanism, we identified cryptotanshinone as a potential Chinese medicine-based pharmaceutic agent for the prevention and treatment of gastric carcinogenesis due to bile reflux.” Bile reflux alters gastric environment The research team analysed the gastric juice samples of 50 patients with bile reflux gastritis (BRG group), 50 patients with gastric cancer (GC group) and 45 subjects in the control group using chromatography and mass spectrometry techniques. It was found that the amounts of BAs, the major component of bile, in the gastric juice samples of BRG and GC groups are significantly higher than in the control group. Furthermore, the acidities of gastric juice samples of the BRG group (pH value about 3.5) and the GC group (pH value about 4) are drastically lower than in the control group (pH value about 2). The phenomenon is explained by the fact that BAs are weak acids compared with strong gastric acid, and their influx into the stomach changed the gastric environment by upsetting the normal acid-base balance of the gastric juice. Further investigation found that a specific type of BA, called taurodeoxycholic acid (TDCA), showed a strong positive correlation with pH value of gastric juice samples of the BRG and GC groups. Previous studies showed that bile reflux is closely related to chronic gastric inflammation and gastric carcinogenesis. The researchers thus examined the concentrations of lipopolysaccharide (LPS), a pro-inflammation cytokine, in the gastric juice of the 145 subjects above, and found that the BRG and GC groups have LPS concentrations significantly higher than those of the control group. Change in microbiota associates with gastric carcinogenesis As LPS is produced and found in the outer membrane of certain kinds of bacteria, the researchers applied gene sequencing and other techniques and confirmed that LPS-producing bacteria are significantly more abundant in the gastric juice of BRG and CG groups compared to the control group. Among these LPS-producing bacteria, a species called P. melaninogenica had the highest relative abundance. From these experimental results, it is suggested that bile reflux induces significant changes in the gastric environment, alters the gastric microbiota, and results in the development of gastritis and gastric carcinogenesis. The hypothesis was tested with a series of in vitro and in vivo experiments in mice, which confirmed that application of TDCA and LPS promotes gastric epithelial cell proliferation, and induces gastric inflammation. Cellular and molecular analysis revealed that P. melaninogenica promoted gastric inflammation in mice by activating the IL-6/JAK1/STAT3 pathway, a chain of interactions between proteins in a cell involved in processes such as immunity, cell division, cell death, and tumour formation. Cryptotanshinone as potential pharmaceutic agent After unveiling the mechanism of bile reflux-induced gastric cancer, the researchers turned to explore a corresponding preventive and therapeutic approach. They focused on cryptotanshinone, a bioactive compound isolated from the roots of Salvia miltiorrhiza, which is a Chinese herbal medicine that facilitates blood circulation with an anti-inflammatory effect. Cryptotanshinone is also known as an inhibitor of the STAT3 signaling pathway in cells. The researchers tested the effects of cryptotanshinone with a bile reflux mouse model developed through surgery. In a group of eight mice without application of cryptotanshinone, three mice developed gastric lesions 50 weeks after surgery. However, in another group of six mice injected with cryptotanshinone, no obvious gastric lesions were observed. The results suggested that cryptotanshinone has abolished the effects of TDCA and LPS in activating the IL-6/JAK1/STAT3 pathway. “Based on the research findings, it can be concluded that cryptotanshinone is a potential Chinese medicine-based pharmaceutic agent for the prevention and treatment of gastric carcinogenesis due to bile reflux. It provides an alternative strategy for the development of medication which targets on the newly discovered mechanism of how bile reflux induces gastric carcinogenesis,” said Professor Jia. Contact Details HKBU Communication and Public Relations Office Christina Wu hkbunews@hkbu.edu.hk

October 25, 2022 09:00 AM Eastern Daylight Time

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