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Kadimastem Announces it raised appx 7.5 million NIS by rights offering

Kadimastem2

Kadimastem Ltd. (TASE: KDST), a clinical stage cell therapy company developing treatments for ALS and diabetes, announces the raising of 7.5 million NIS in a rights offering. The company's main stakeholders, Prof. Michel Revel and Mr. Julian Ruggeri, and the European Alpha Capital Anstalt, expressed confidence in the company and participated in the rights offering. Cybele Investments served as a distributor to the transaction. Attorneys Reut Alfiah and Oded Har-Even, of Sullivan & Worcester, accompanied the company in the transaction. A little over a week ago, the company announced the approval of a NIS 3.5 million (US$1 million) budget grant by Israel-U.S. Binational Industrial R&D Foundation (BIRD) to support Kadimastem and iTolerance Inc.’s joint project to develop and commercialize a breakthrough regenerative technology to cure diabetes without the need for chronic immuno-suppression. The total project budget is NIS 7 million, for a period of 30 months. iTolerance is a US company based in Florida that has developed an innovative technology (iTol 100) with the aim of enabling the transplantation of allogenic cells (genetically different from the patient) without tissue matching and without suppressing the recipient's immune system. In preparation for the rights offering, the Company provided a voluntary update on its activities. Regarding the AstroRX product for the treatment of ALS, the company has updated that it intends to submit an IND to the FDA for a phase II/a clinical trial by the end of January 2023. For the submission, the company hired an American CRO for the purpose of planning and implementing the clinical trial. In addition, the company is in contact with experts in the field in the U.S., in preparation for their potential participation in the execution of the clinical trial and is examining potential sites for execution of the experiment. Regarding the IsletRX product for the treatment of diabetes, the company has updated that following the engagement with the French company Defymed, which develops advanced encapsulation solutions for examining an integrated solution for the treatment of diabetics, the companies are in advanced negotiations for cooperation to develop a joint product in the field of diabetes. Regarding the intention to list on NASDAQ, the company has updated that it is in the process of preparing for a dual listing on NASDAQ. The Company also updated that it is in initial communication with a private company to examine a strategic investment in the company and/or strategic cooperation. Asaf Shiloni, CEO: "The raise from the main stakeholders who have been accompanying the company since its inception, gives a boost to the company's development plan and will allow us to securely move forward with the submission of the IND to the American’s FDA, and to move towards a phase IIa clinical trial in the US for patients with ALS." Ronen Twito, Chairman: "We welcome the confidence of the company's main stakeholders in its management, the company's assets, and the quality of science, at a time when the world's capital markets are unstable. I am confident that we will continue to lead Kadimastem to successes and the realization of its potential." About Kadimastem Kadimastem is a clinical stage cell therapy company, developing and manufacturing "off-the-shelf", allogeneic, proprietary cell products based on its technology platform for the expansion and differentiation of Human Embryonic Stem Cells (hESCs) into functional cells. AstroRx®, the company's lead product, is an astrocyte cell therapy in clinical development for the treatment for ALS and in pre-clinical studies for other neurodegenerative indications. IsletRx is the company's treatment for diabetes. IsletRx is comprised of functional, insulin and glucagon producing and releasing pancreatic islet cells, intended to treat and potentially cure patients with insulin-dependent diabetes. Kadimastem was founded by Professor Michel Revel, CSO of the company and Professor Emeritus of Molecular Genetics at the Weizmann Institute of Science. Professor Revel received the Israel Prize for the invention and development of Rebif®, a multiple sclerosis blockbuster drug sold worldwide. Kadimastem is traded on the Tel Aviv Stock Exchange (TASE: KDST). Contact Details Kadimastem Sarah Bazak s.bazak@kadimastem.com Lior lior@gotlive-ir.co.il, s.bazak@kadimastem.com

January 09, 2023 07:01 AM Eastern Standard Time

Over 60% Of Americans Will Experience Back Pain At Some Point - FloSpine’s Solution Makes Surgery Easier, Cheaper, And More Accessible

FloSpine

By Faith Ashmore, Benzinga Interested in investing in FloSpine’s campaign? Click here to get started! Outpatient and inpatient are entirely different worlds in healthcare. Inpatient care refers to anything that happens in a hospital setting and is designed to provide care for patients who might require overnight care. On the other hand, outpatient facilities are built to accommodate procedures that can be done within a day and require less monitoring afterward. Outpatient care, where applicable, has lots of benefits for the patient and practitioners alike. Outpatient care is typically much cheaper than inpatient; there are no hidden or additional fees for things like maintaining a large staff and resources. Sometimes it costs thousands of dollars more for inpatient care versus outpatient. Patients are also able to recover in the comfort of their own homes with outpatient care, a huge draw to many people. COVID-19 has shined a spotlight on the benefits of outpatient facilities, sometimes known as ambulatory surgery centers (ASCs). High patient volumes at hospitals left providers itching for more facilities to provide patients with care at. Not to mention ambulatory surgery centers have resulted in millions of dollars of healthcare savings for providers. Ambulatory surgery centers are only expected to grow in the coming years. The market is expected to grow steadily at a CAGR of 7.5% through 2029. As the Centers for Medicare & Medicaid Services announce more procedures that are approved for outpatient facilities, the popularity of ambulatory surgery centers will only grow further. Spinal Surgery Is Moving To ASCs While major spinal surgery will remain in the jurisdiction of major hospitals, smaller surgeries or minimally invasive spinal procedures are having success at ASCs. Currently, there are more than 160 outpatient surgery facilities in the U.S. that specialize in spinal care. According to data compiled by CardinalHealth, the spine ASC market is expected to grow 200% in the coming years. Spinal fusion implants are one of the approved procedures that are having success in ASCs. Spinal stenosis occurs when a patient’s spinal disc begins to collapse and pinch the nerve roots and spinal cord; this breakdown of the spinal cord can cause pain, mobility issues, and overall deterioration of health. Traditionally practitioners have implanted rods and screws to correct spinal stenosis. FloSpine has pioneered a new device that can replace the existing rod and screw fusion solution. Their proprietary product, The KeyLift™ Device, is inserted through a small incision (about 2 inches). This device and procedure lead to faster patient recovery and less blood loss while limiting the chance of bone cracking because of how it fits in between the laminar of the spine. The company has already had success in the minimally invasive surgical technique industry with its Largo®, Canaveral®, and Panama® products. It is currently hosting a raise to finish the development and execution of its KeyLift Device. One major benefit of the KeyLift Device is the procedure can be performed in ASCs and limits costs to the patient while increasing long-term spinal health. Approximately 60-70% of Americans will experience back pain at some point in their life, making the importance of innovative spinal fusion implants incredibly important. FloSpine could be a leading innovator in the space helping make the lives of many easier. This article was originally published on Benzinga here. At FloSpine, we have developed a new solution to treat back pain, the KeyLift™. The KeyLift™ is implanted and expands to release nerves that are under pressure due to aging or injury. This condition is known as lumbar spinal stenosis and we believe that we have a new solution to treat it. We consider ourselves to be a leading medical device company applying new technology and design concepts to solve medical problems for the human spinal column. With 6 US patents, and 4 Patent Applications (2 International), we are in review with the FDA for the latest solution for back pain: KeyLift™. FloSpine® is registered as a Medical Device Manufacturer with the Food and Drug Administration (FDA). This post contains sponsored advertising content. This content is for informational purposes only and not intended to be investing advice. Contact Details Waldi Harris wharris@flospine.com

January 06, 2023 08:05 AM Eastern Standard Time

Oxford Cannabinoid Technologies "ready to go" after phase 1 trial submission

Oxford Cannabinoid Technologies Holdings PLC

Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

January 06, 2023 04:58 AM Eastern Standard Time

Video

Change Addressing Disparity for Black Kidney Patients Takes Effect

United Network for Organ Sharing

Black patients disadvantaged by a race-based measure of kidney health will now be eligible to receive modifications to their waiting time, potentially improving their prioritization for transplant, according to a new policy passed by the Organ Procurement and Transplantation Network (OPTN) Board. United Network for Organ Sharing (UNOS), the organization that powers the nation’s donation and transplant system, serves as the OPTN under federal contract. The new policy went into effect today, January 5, 2023. The change was unanimously approved by the OPTN Board on December 5, 2022. The policy is intended to address disparities in waiting times faced by Black patients on the kidney transplant waitlist. Some of these patients were disadvantaged by the earlier use of a measure that took race into account when measuring kidney function. For years, some calculations (known as eGFR) included a modifier for Black patients based on outdated assumptions about race and biology. This practice led to the severity of kidney disease in Black patients being systemically underestimated. It may have also negatively affected when Black patients got added to the national waitlist. In June 2022, the OPTN Board approved a policy that required transplant hospitals no longer use race-based calculations when estimating a patient’s kidney health. “This action underscores our commitment to equity in access to transplantation for all candidates,” said Jerry McCauley, M.D., M.P.H., president of the board. “We and many other organizations have now prohibited the use of a race-based calculation that has unfairly delayed care for many Black patients with kidney failure. Waiting time for a transplant is a major factor in the priority that kidney candidates receive. Thus, we are acting along with kidney transplant programs nationwide to ensure that any candidates known to have been disadvantaged by a race-inclusive GFR calculation will receive all the waiting time credit for which they qualify, as soon as possible.” “So many African-Americans have been affected by the use of race-inclusive calculations, and have become very ill or have died waiting for the opportunity to list for a kidney transplant,” said Precious McCowan, a kidney recipient and donor mother who serves on the OPTN Kidney Transplantation Committee, which developed and co-sponsored the policy with the OPTN Minority Affairs Committee. “With the new policy change, I envision more African-Americans having an equal opportunity to list for kidney transplantation.” Transplant programs must comply with the policy by January 3, 2024, which will include reviewing their lists of waitlisted candidates to identify those who may have been impacted by the use of the race-based calculation. About UNOS United Network for Organ Sharing (UNOS) is a non-profit, charitable organization that serves as the Organ Procurement and Transplantation Network (OPTN) under contract with the federal government. The OPTN helps create and define organ allocation and distribution policies that make the best use of donated organs. This process involves continuously evaluating new advances and discoveries so policies can be adapted to best serve patients waiting for transplants. All transplant programs and organ procurement organizations throughout the country are OPTN members and are obligated to follow the policies the OPTN creates for allocating organs. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

January 05, 2023 02:39 PM Eastern Standard Time

News Release

NuggMD releases landmark 210k-record patient study on medical cannabis trends

NuggMD

As legal cannabis continues to enjoy broad, bipartisan support among the general public and as more states legalize the substance for either medical or recreational purposes, a recently released landmark study sheds new light on the conditions for which patients seek medical cannabis and how those conditions vary by geographic region, age, and gender identity. The study, the 2022 Cannabis Conditions Report, was conducted by NuggMD using more than 210,000 anonymized patient records, among the largest data sets of its kind. NuggMD is a telemedicine provider that helps patients obtain medical cannabis cards in 22 states. It conducted the study in order to add more facts to the prevailing dialogue about the addition of medical cannabis to a treatment regimen. The full report is available here. It was first reported by Marijuana Moment, one of the nation’s leading trackers of developments and news in the cannabis industry. Concurrent with its Conditions Report, NuggMD also released the details of a complementary survey of more than 500 current medical cannabis card-holders. Importantly, 68 percent of respondents said they have ceased or reduced other pharmaceutical treatments since incorporating medical cannabis. More than 80 percent of respondents said they are comfortable discussing medical cannabis with their doctors, and more than 94 percent said cannabis provides to them moderate or total relief of the conditions for which they sought treatment. "The evidence here is clear: medical cannabis works. It provides relief for a wide variety of conditions. More importantly, it's giving patients an alternative to dangerously addictive, often deadly pharmaceuticals. More than a century of disinformation and propaganda peddled by cannabis foes does not change these facts,” said Alex Milligan, co-founder and chief marketing officer of NuggMD. Analysis: Inconsistent standards limit access and create unreliable data Still, a significant barrier to access is how states limit the qualifying conditions for which a patient may be recommended medical cannabis. In some states, legislators have expanded their regulations to include more qualifying conditions or to allow physicians to recommend medical cannabis in broad terms, such as for treatment of a “debilitating medical condition.” Other states continue to unjustly prohibit their residents from accessing this form of healthcare. Of note, the states that allow physicians to determine the qualifying condition saw a higher rate of patients reporting “other condition” as a reason they were seeking medical cannabis. Based on that datapoint, NuggMD believes that states with fewer qualifying conditions are either deterring patients from seeking the medication they need or reducing the accuracy of available data by forcing patients in need of medical cannabis to select a comorbidity rather than the primary ailment for which they were seeking an evaluation. A majority of patients in the study listed multiple conditions, which can be expected as many conditions exist co-morbidly. “From a policy standpoint, one piece of low-hanging fruit for lawmakers is more consistency to the qualifying conditions under which states approve medical cannabis licenses for patients,” said Milligan. “The current status quo does not promote equal access to care or the evidence-based evaluation of medical outcomes, which are both cornerstones of other areas of healthcare.” The report was authored by NuggMD's Alexandra Arnett, a University of Maryland School of Pharmacy candidate for a Master of Science in Medical Cannabis Science and Therapeutics. Medical review was provided by Dr. Brian Kessler, MD, Pain Management & Sports Medicine, with analysis, editing, and fact-checking conducted by NuggMD's Tyler Elson and Deb Tharp. About NuggMD NuggMD is the nation's leading medical marijuana technology platform, serving patients in California, Connecticut, Georgia, Illinois, Iowa, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Jersey, New York, Ohio, Oklahoma, Pennsylvania, Texas, Vermont, Virginia, and West Virginia. They've connected over 1,000,000 patients face-to-face with their new medical marijuana doctors via their state-of-the-art telemedicine platform. They believe every human being has the right to explore the benefits of medical cannabis and are fully committed to helping each patient explore every option in their journey to wellness. For further information, visit NuggMD.com. Contact Details Andrew Graham andrew.g@getnugg.com Company Website http://www.nuggmd.com

January 05, 2023 02:11 PM Eastern Standard Time

Variational AI Files Two US Provisional Patents for Potential COVID-19 Drug Created by Generative AI

Variational AI

Variational AI, developer of the Enki™ generative artificial intelligence (AI) drug discovery platform to redefine the economics of drug development, today announced that the company has filed two provisional patents with the United States Patent and Trademark Office (USPTO) related to new chemical entities (NCE) successfully created using generative AI. Variational AI’s protease inhibitors are among the first NCEs created via a purely generative model and will be useful in the development of COVID-19 drugs as part of the company’s coronavirus antiviral program. Of even greater significance, this method underscores the potential of generative AI to create novel, efficacious, safe, and synthesizable molecules. “The filing of these patents is a concrete milestone not just for Variational AI, but for the applicability of generative AI to the domain of drug discovery,” said Handol Kim, co-founder and CEO, Variational AI. “Whereas adoption of AI for drug discovery is accelerating, until now it has been based on older discriminative models. Though powerful, these models are essentially just performing faster and better virtual screening of known or existing molecules. Enki™ does not screen, but rather truly creates new molecules, similar to how other generative AI models like DALL-E and ChatGPT create novel images and text based on prompts. In our case, we use the language of chemistry as prompts to describe the molecules we want.” While generative AI has recently been applied at scale to the creation of novel images, text, music, video, and software code, the successful application of generative AI to drug discovery is still nascent but potentially transformative. Variational AI’s platform created two novel lead candidates that each bind differently and distinctly to the SARS-CoV-2 main protease, the most promising therapeutic target implicated with COVID-19 across variants and potentially other coronaviruses. The platform is based on a generative model framework known as a variational autoencoder (VAE) and created these lead candidates after being trained on large sets of public and proprietary data including older SARS-CoV (SARS) main protease data. The candidates demonstrated potency, selectivity, and novel binding modes on the SARS-CoV-2 main protease that show potentially better safety profiles compared to the existing standard of care. Variational AI is now focused on training Enki™ for multiple drug targets in oncology and making rapid progress in this disease area, leveraging learnings from its success in antivirals, as well as other disease areas. “Our team of machine learning researchers has been developing and applying generative models for years, long before the recent interest,” said Jason Rolfe, co-founder and CTO, Variational AI. “Drug discovery is a massively difficult undertaking, yet we continue to make rapid progress working hand-in-hand with our drug discovery team as we move to addressing unmet medical needs in oncology and beyond.” Funding for this work was supported in part by Canada’s Digital Technology Supercluster in collaboration with adMare BioInnovations and the University of British Columbia. About Variational AI Variational AI uses generative AI to create novel and diverse compounds that are optimized for multiple properties to avoid the most common causes of drug attrition and increase clinical probability of success. Variational AI works with leading biopharmaceutical partners and is developing its own internal pipeline. To learn more, visit https://variational.ai. Contact Details SVM Public Relations Jordan Bouclin +1 401-490-9700 variationalai@svmpr.com Company Website https://variational.ai/

January 05, 2023 10:00 AM Eastern Standard Time

News Release

10 Best Essay Writing Services in the USA: TOP College Paper Writing Websites

Genuine Papers

A stitch in time saves nine. So, as a student, you may want to ask, “Can I prevent low grades in my academic essays?” The answer is yes, especially with the assistance of paper writing services waiting for you to take advantage of their experienced writers. But are you ready to meet them? Before sharing this list of the TOP rated essay writing companies in the United States, you should know the criteria for choosing these websites. To start with, they have excellent writing consistency with many repeat customers. Furthermore, first-time buyers often commend them for quality and prompt delivery. These services have respect for deadlines and submission dates, making them the joy of many students worldwide. Again, these are the best American essay writing services available online today, because of their excellent customer support. Their customer care team is fully armed with all it takes to answer all your inquiries and tend to questions posed to them when you reach out. Also, they keep tabs on your order on their platform. If you are looking for more reasons to check them out, know that when you hire them, you will receive plagiarism-free content. That is, your essay is original. Thus, you would not have to worry about it being flagged by your professor or any plagiarism checker software. All you have to do is check the internet for more proof of excellence. The digital world is littered with many positive reviews. So, do you want to be one of their lucky customers? To make things much easier for you, we have provided a well-curated list of the best essay writing services in the next college season in the United States. These companies were well researched and added to this updated in January, 2023 rating based on excellent turn-ins over the years from their clients and prompt delivery. The List of the 10 Best Essay Writing Services in USA PaperHelp - the best college essay writing service today in the United States. 99Papers - recommended for New York students. SpeedyPaper - same-day writing company. EssayPro - the cheapest U.S. paper writing provider in 2023. MyAdmissionEssay - the best essay service in Florida. EssayBox - a professional American website to hire writers online. IQEssay - "do my essay" qualified writers from Ohio. Studdit - newest company to buy an essay from Texas. SuperbPaper - company from Arizona that can write your essay. PaperCoach - trusted MBA essay writing service est. 2012. Now, we can see what advantages they have and what features they may cover for students looking to get the best service for their grade. Let's check full trusted reviews from experts for each website. 1. PaperHelp PaperHelp is one of the most popular essay writing services in the United States today. And their place in the market is that of the top seat in 2023. Well, they go to that level from sheer grit in their excellence creed since their inception in 2008. And that is reflected in the quality of their deliveries to their customers. When you order from them, they strive to give an experience commensurate with their creed of being the best essay writing service. The reason for that is not far-fetched. They simply realize that human referrals are the best way to keep their business booming. So, if they make you feel good, they have invested in their publicity among your friends and colleagues in school. Ordinarily, you are bound to get hooked on their website. Most customers buy from them because of how super intuitive their interface is. It is both easy to understand and navigate. The website layout, design, graphics, and interactions are cool, making you stay on the website long enough to order from them. All these contribute to their efforts to give you the best experience possible as you order. Thus, they do not only deliver excellent written-from-the-scratch content for you, but they also make sure that your process of ordering and getting the content delivered to you is as seamless as possible. Their customer journey reflects how much they put into your work to make t come out beautifully. Now, nice graphics aside, can they write your essays well? With tons of feedback, reviews, and comments from many reliable sources, PaperHelp does not only have first-time buyers. They have a ton of repeat buyers who are always on edge to order from them. Why? Because the platform delivers excellent delivery to them all the time. So, why go elsewhere when I am being served excellently here? Right? Thus, you should know that PaperHelp creates fresh content for your essays and promptly delivers with 0% plagiarism. And they can also tend to all forms of essay writing services you might require. That is, from a highschooler essay to the most academically complex ones such as Ph.D. dissertations. All are welcome and can be excellently written by their professional writers. Speaking of professional writers, they have an army of seasoned writing specialists with rich academic writing experience. Most of these writers are academics themselves. So, they are familiar with the in and out of the most complex essays, theses, and dissertations. On the PaperHelp platform, these writers can turn in essays with an urgent deadline as fast as 3 hours. And with just $10.00, you can have a good paper written for you. Also, you can monitor the progress of your work on the control panel with options for other means of communication, such as toll-free numbers, Skype, Facebook Messenger, and the PaperHelp app. 2. 99Papers Are you a New York student? Then get in here. 99Papers is perhaps the best writing service you will encounter as a student. As one of the oldest platforms, they have rich experience in how to write essays for varying academic difficulties. All you have to do is order from them and see the magic. You may be wondering what is unique about them. Of course, their existence is a distinctive factor. However, it is not the major propelling reason many people buy from them. They simply deliver quality. This feature stands out to most of their customers. They create original essays, not plagiarized ones. They offer plagiarism reports on request. Further, they have a considerably low-price range for an essay per page. By the way, they are one of the essay writing services with a wide range of essays they can write. Whether you are a high schooler looking to work on a mini-essay or a full-blown academic looking to get an A in your dissertation as a Master's student, all of your writing needs can be well met at 99Papers. And with just $9,95 per page, you get access to a well-written essay. This is coupled with several discounts on their website that you can benefit from when ordering, especially if it is your first order. You also enjoy some premium features with this piece, such as proofreading or plagiarism check. Unlimited revisions, bibliography, and title pages are also free of charge on their platform. Little wonder many students looking for where to save some buck and still get stellar work opt for this writing service. Also, 99Papers places a premium on their writers. They are quite strict on the admission of people into their writing intelligentsia. They verify their writers' academic backgrounds and only hire those with rich writing and knowledge experience. Interestingly, some writing experts work in reputable universities such as Yale, Cambridge, Oxford, Berkeley, etc. All these extra efforts in recruitment are so that they can always serve the customers with only quality orders. Similarly, their customer support is also made of quick-response and prompt personnel. Do you know that their average response time is 10 seconds? Yes, that is quite remarkable for a company as big as that. 3. SpeedyPaper This essay writing service is called SpeedyPaper for a reason! Their response rate to essay delivery is one of the fastest in the entire American market. And it is one of their major selling points. Most of their buyers, mostly from California, reach out to them when they need an essay written within hours. And when you make this kind of quick order, their prices do not unnecessarily shoot off the roof to scare you away. No. Another thing that stands out for most people is the level of quality retention. That is, their essays are both quickly done and excellently written. With them, you can expect your essay to be well-researched and grammatically compliant without plagiarizing or stealing from another source. If you need an essay in 6 hours, they can take on the order and deliver it efficiently. Further, if you are looking for a synonym for SpeedyPaper's support team, the phrase you are looking for might be "as fast as lightning". They respond swiftly to all new buyers' inquiries, complaints, and comments from their current customers. Little wonder they have an outstanding reputation in public for their beautiful work culture and customer relations. They also have a high rating with many review sites that have taken a recount of how good their service is. The customer support swiftness is part of the SpeedyPaper attempt to make your order from them and enjoy one of the best customer services out there in the essay writing services space. In addition, their pricing is quite affordable for most people. Their rates start at $9 per page for high-school-level writing on a 14-day deadline. However, several things may affect the price by lowering or increasing it. And one of these is the use of coupons on their websites. That might lower how much you have to pay cumulatively for your order. If you request a plagiarism report or the deadline for your turn-in is shorter than usual, you might have to pay more than what you would ordinarily have to pay. 4. EssayPro If you mention the names of the best cheap essay writing services from U.S., EssayPro will make its way to that updated list. The reason for this high ranking is not far-fetched; they have etched a distinct experience in the minds of all their customers. And that is the fact that they offer a wide range of services on their platform. With all the different forms of essays you can get with them, you can also rest assured that your orders are safe and will be done to your taste. They do essay writing, editing, rewriting, as well as proofreading. Many buyers have found themselves iterating between EssayPro and other writing services, yet choosing the former every time they are left to pick where to get their essays done. This shows that this writing service is trusted by many in the market. Checking out their website gives you a lot of straightforward ease with ordering. For example, the first thing you see on their website is a price calculator. It asks for your preferences, such as the paper's type, length, and deadline. This is to determine a minimum price per page. You can get a well-written essay for just $10.8 per page. And that is especially if the deadline is around 5 days. However, depending on the academic difficulty and the short deadline involved in the order, the price might go up to around $14.36 per page. And the price is quite reasonable compared to many other services in the market. Further, EssayPro also runs discounts that many of its buyers look forward to. Usually, the discounts depend on the number of pages you are ordering and the times you have ordered from them. The discounts range between 10% to 33%. Also, their FAQ section reveals that there is a referral program. And you get a $10 PayPal transfer when you bring a new customer, and they order from their platform. 5. MyAdmissionEssay Are you in Florida and looking for the “write my essay service” you should patronize? Then your search has ended. EssayFactory has proven itself as a strong name for delivering excellent content for its customers. They are known for creating from-the-scratch content with no plagiarism. They are so confident in their essays that they are willing to provide plagiarism checks for all that request them. As a result, many students have made them solace when it comes to writing excellent essays to achieve better academic results. Be it a high school grade essay or more academically difficult ones such as theses or dissertations; they are ready to woe your teachers and supervisors with their excellent writing skills. Furthermore, they have such a good reputation for their writing in the USA because of their team of expert writers. These folks strive to achieve top-grade writing every time they touch the keyboard. Every time they write, their works go through a thorough and immersive plagiarism check and review before such a paper is delivered. As a result, they ensure minimal to zero grammar or spelling mistakes. Not only that, but they also ensure that you receive prompt delivery of your order. Interestingly, they have one of the best support teams in the industry. Their customer support teams are available 24/7, and they are ready to attend to all your inquiries and complaints if you ever have any. They are also known for fast response and finding the best solutions that suit you as an individual and not generic responses that would put you off balance. They are available to speak to you via chat or phone. You can also access them via the email indicated on the website. 6. EssayBox EssayBox is another notable name in the U.S. essay writing service market. From ordering on their website to receiving your order, this writing service strives to give you a seamless experience with getting your essay written on their platform. Whether it is a basic high school essay or a full-blown dissertation or thesis, you can rest assured that you will be getting good and original content at the end of the delivery. Ordering on their website is quite easy. And this is because their website is suited to give you a great welcoming experience. And it is designed so that all the necessary infographics, promos, discount codes, reviews, and price calculators are available at first contact. Also, the color scheme is carefully chosen. It does not disturb or distract the eyes from the most important details needed. You can put your heart at rest when it comes to the quality of writers on their platform. This is because they hire native speakers who can write effectively in UK English and the US. Their writing specialists undergo some language tests before allowing them to take orders on the platform. Thus, as a customer, you can choose the writer you would like to attend to your order based on their qualifications, field of expertise, and experience. In case you are wondering, EssayBox charges $12 per page. However, depending on the specifications of your order, there might be a few tweaks to the eventual price. These specific adds could be the academic difficulty of the paper, deadlines, the number of pages, topics, etc. In addition, they offer services like revisions, inquiry, titles, outlines, and bibliography for free. 7. IQEssay IQEssay is that one-stop shop for all of your essay writing needs. You need not stress too much about most of their papers. Their customers trust them to deliver quality all the time. This is attested to by innumerable comments, reviews, and positive feedback they have garnered over the years of working as a top-notch essay writing company based in Ohio, USA. They are another writing service that most USA students rush to when they need their assignments done. This is because they not only have a sterling reputation for excellent papers written for you, but also deliver your papers promptly. Thus, if you are looking for expert writers from the U.S. who can give you a great paper within a short time frame of delivery, you can check out IQEssay. Since 2005, they have specialized in making geniuses of many students by assisting with papers ranging from short essays to exam notes, proofreading, and editing, or a full dissertation. They also offer some services not common to most essay writings service. And one of them is a CV writing service. They also write personal statements, assignments, etc. In short, they are available to help you to achieve your academic, business, or even personal goals. And with all these, you can be at rest of a high standard work to be done on your work. Not only that, but they also respond promptly to all of your orders regarding delivery. The pricing of IQEssay, like every other platform in the market, can be influenced by the order's specifications. You can get an excellent article within a 30-hour delivery for $30 per page. And this price is influenced by the caliber of writers that work on your order. Also, they give their customers discounts that aid their pay on the platform. A good example is the 20% slash on orders if you are buying paper from them for the first time. 8. Studdit With hundreds of positive reviews about them from Texas college students, Studdit has a strong root in the industry as one of the strongest names. This reputation is one of reliability and trust. They will write your essay and other related writing services like a CV from you from scratch. Not only that, but you would also be able to present a plagiarism-free essay to your supervisor for your dissertation and theses. Little wonder many students keep going back to them to write their academic essays, difficulty level notwithstanding. Thus, whether you are a high schooler needing an assignment written or a postgraduate student looking to wow your supervisor, all writing needs are ably met on the Studdit platform. Further, Studdit can brag of sterling, original, and quick content because of their team of writing specialists. This platform particularly has a great knack for treating its writers well. 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The writers who work on these original and prompt contents are in categories. You have an opportunity to pick the ones you prefer to work on your order, only that it might increase your price a little. This service also has a strong support team always available to you. They are ready to answer all your questions, including pricing. So you can rest assured that you will get a special delivery at $8 per page. FAQ How an essay writing services work? American essay writing services are one of the easy-to-navigate services in the world presently. And you do not need to search all over the internet to find them. We have carefully curated them for you above. So, as highlighted above, you can choose any of the best essay writing services in 2023. But note that ordering most of these writing services is quick to understand. You do not have to struggle much with them. Most of what you need to make a successful order is on their website. 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It is legal and ethical to use the help of expert writers to assist in your essays when you cannot work on them yourself. This eases the burden on you and allows you to focus on most things you need. Most of the essays are written from your order specifications. Thus, you are guiding the mind of the writer to help you write based on the resources you have made available. Students who are the breadwinners of their families or those who work two jobs to support themselves through school are incapable of writing essays. There are even students without a proper grasp of the English language. How can they write essays and score high grades in their academic pursuit? Asking for help is not a bad thing and would not be one. Using the services of an essay writing service is simply asking for help from an expert writer. And that's okay and cool. Legitimacy of buying an essays in the United States Buying essays in USA online is 100% legit. However, it depends on where you decide to buy your essays. If you decide to buy them from unverified sites or platforms, you are left alone to face the brunt of whatever comes your way. But to avoid this, we have listed and carefully explored each service we consider the best in the market. And they are all completely legitimate. No need to fear using them. Just get your purse ready and order away! Most of them have a lot of online reviews, so you can check them out before putting your money on any of them to make an essay purchase from any of their writers. Further, you would get fully original content from these websites. Not plagiarized ones that unverified sites bring your way. So, you do not need to be afraid that plagiarism checker software will flag your content or that your supervisor will think you stole the research from somewhere. You would enjoy complete transparency with excellent content delivery. That sound like a legit platform to us. Don't you think? 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You can also choose to speak with them via phone if you so choose. How to hire somebody, who can write a professional essay for me? There are tons of ways to hire somebody to write essays for you. However, many of these paths lead to meeting the wrong folks on the internet. Fraudsters posing as good essay writing services are very rampant these days. And the only way to interact with trusted and reliable professional services online is via the lists of services we have made available above. These have a simple approach to ordering from them. And they are always ready to be hired to work on any of your writing needs that might surface at any time. Hire somebody to write your essays for you is easy today in USA. Since you have the internet and can scroll through, you can access the above-mentioned platforms. So, if you are a student on the lookout for platforms that can help you best craft a great paper that would make your supervisors smile at you, then consider using any of the services listed above. They have been carefully curated just for you for this purpose. A few words in conclusion Your future is in your hands. Likewise, a sage affirms that a man is the architect of his destiny. This means that, as humans, we can pick from available options and carefully plan for the life we want to see. The same goes for you as a student today seeking to be one of the best in his class or level. The truth is, it is your choice to either ask for help or not. If you cannot write your essay, contacting professional essay writing services in the USA would be a great choice. Seeing that the essay writing services highlighted above are available to tend to all the writing needs of students, it becomes easier to pass courses. Most courses and subjects have a larger chunk of their marks allocated to assignments and papers/essays, which expert writers are ready to take; perhaps you cannot do it. Even if you can but still require an expert's perspective, you should buy your essay from these platforms. Take a step in the right direction toward your stellar academic future today! Contact Details Martina Brenwood usa_writers@best-essay-services.com

January 04, 2023 11:15 PM Eastern Standard Time

UNOS Leadership Requests USDS Engagement Concerning Leaked Report and Impact on Patients

United Network for Organ Sharing

Senior leadership at United Network for Organ Sharing (UNOS), the federally contracted non-profit that unites the organ donation and transplantation community and serves as the Organ Procurement and Transplantation Network (OPTN), have raised concerns with a draft report by the United States Digital Service (USDS). In a letter sent today to USDS Administrator and Deputy Chief Federal Information Officer Mina K. Hsiang, UNOS leadership shared that in 2022 its organization received a supposed draft report by the USDS concerning its information technology (IT) systems. The letter was authored by UNOS Board President Dr. Jerry McCauley, Vice President/President-Elect Dr. Dianne LaPointe Rudow, Past President Dr. Matt Cooper, Vice President of Patient and Donor Affairs Valinda L. Jones and Interim CEO Dr. Maureen McBride. “As noted in an August 2, 2022, letter to the HRSA Administrator, we would have welcomed a USDS review of our system, but did not receive notice of this review before, during or after its development, nor are we aware of a final version of the document,” wrote McCauley, Rudow, Cooper, Jones and McBride. “A safe, reliable, and secure technology infrastructure for the national donation and transplantation network is of critical importance to the public and the patients we all serve, and UNOS would be pleased to support the USDS’ work in updating and finalizing the report.” The leaders went on to request a meeting with the USDS to mutually review and discuss the draft report and invited the USDS to conduct an in-person review of its IT systems. The report, which was leaked to members of the press last summer, served as the basis for public discussions surrounding the IT infrastructure for the national donation and transplantation system. Routine audits of UNOS technologies are performed by the Health Resources and Services Administration (HRSA) and have not identified the findings outlined by the USDS report. “We believe both UNOS and the USDS want the same thing: to get as many donor organs as possible to the patients who need them, both equitably and efficiently,” wrote McCauley, Rudow, Cooper, Jones and McBride. “We both want to improve organ donation and transplantation in a way that’s based on facts, and without service interruptions in a system upon which so many patients, professionals and clinicians depend.” A safe, reliable and secure IT infrastructure is instrumental to the continued success of the U.S. organ donation and transplantation network. The IT system that powers the OPTN is highly effective and secure, helping make over 41,000 transplants possible per year nationwide and fending off over 3,000,000 hacking attempts per day. Also copied on the letter were HRSA Administrator Carole Johnson, HRSA Acting Associate Administrator Suma Nair, HRSA Chief Information Officer Adriane Burton, U.S. Chief Information Officer Clare Martorana and U.S. Office of Management and Budget Director Shalanda D. Young. A copy of the full letter can be found here. About UNOS United Network for Organ Sharing (UNOS) is a non-profit, charitable organization that serves as the Organ Procurement and Transplantation Network (OPTN) under contract with the federal government. The OPTN helps create and define organ allocation and distribution policies that make the best use of donated organs. This process involves continuously evaluating new advances and discoveries so policies can be adapted to best serve patients waiting for transplants. All transplant programs and organ procurement organizations throughout the country are OPTN members and are obligated to follow the policies the OPTN creates for allocating organs. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

January 04, 2023 02:36 PM Eastern Standard Time

Programming, Writing and Research skills dominate the freelance job market

FREELANCER.COM

Freelancer.com (ASX: FLN) (OTCQX: FLNCF), the world’s largest freelancing and crowdsourcing marketplace by number of users and jobs posted, today released its quarterly Fast 50 Index for Q4 2022. The index, which is based on data from 372,000 jobs posted on Freelancer.com between October 1 to December 31st 2022, ranks programming, report writing, and research related jobs among the fastest growing skills on the platform. At the end of the year, many businesses and companies often rely on freelancers to assist with high volume tasks. According to the Q4 data, the leading tasks for the end of 2022 were Report Writing, Research and Technical Writing. These job types were trending as employers were hiring freelancers to support them with compiling 2022 retrospective reports, creating strategic plans for 2023, and writing business reports. Research jobs also spiked as many entrepreneurs aim to start businesses in the new year, increasing the number of market research and business plan projects posted to the platform. Report Writing (up 59.5%, from 3,374 to 5,384) takes the number one spot in the index when ranking the percentage growth of more than 2,000 skills available on Freelancer.com. Coming in a close second is the skill Matlab and Mathematica (up 56.4%, from 1,250 to 1,955), which are separate programming languages used by engineers and scientists to analyze data. Research jobs and Research Writing rank as the third and fifth fastest growing skills, up by 36.3% (from 3,905 to 5,325) and 32.1% (from 7,527 to 9,944), respectively. Top 5 Fast Growing Skills for Q4 2022: Report Writing - up 59.5% Matlab and Mathematica - up 56.4% Research - up 36.3% Web Scraping - up 32.6% Research Writing - up 32.1% A sudden increase in projects for tech and IT related skills on Freelancer is a continuation of the trends observed in Freelancer’s Fast 50 for Q2 2022 and Fast 50 for Q3 2022 - where freelance jobs for software, app and website developers surged as a result of global tech layoffs. In Q4 2022, the data reveals the new trend is employers hiring for programming jobs, as skills specific to programming dominated the rankings. Web Scraping, often used for lead generation and price monitoring, came in as the fourth fastest growing skill, increasing by 32.6% (from 3,891 to 5,162). C Programming and C++ Programming, general-purpose programming and coding languages used to develop systems and applications, increased by 28.9% (from 4,974 to 6,415) and 23.7% (from 4,775 to 5,907), respectively. Jobs requiring skills in Python, a high-level, general-purpose programming language, also grew by 20.7% (from 10,712 to 12,931). Adding to the growth of engineering-related programming Matlab and Mathematica, projects seeking skills in Engineering also increased in Q4 2022 with Electrical Engineering jobs growing by 25.6% (from 2,305 to 2,897) and Mechanical Engineering jobs increasing by 17.3% (from 1,544 to 1,812). “The latest index truly demonstrates the breadth of skills and jobs available on our platform. We have employers turning to freelancers for content jobs, such as writing and research projects, all the way to highly complex jobs like mathematics, programming and engineering. The trend that we continue to see is the surge in tech-related projects as a result of global tech layoffs,” said Matt Barrie, Chief Executive at Freelancer.com. While programming specific skills grew in Q4, other tech-related skills ranked as some of the fastest falling jobs of the quarter. CSS3, an advanced language used to style web pages, ranked as the fastest falling skill and was down by 67.8% (from 1,227 to 395) in Q4 2022. A similar skill for web page development called AJAX also decreased by 51.8% this quarter (from 1,763 to 849) after ranking as the second fastest growing skill in Q3 2022. As both of these website development skills decreased, jobs relating to WordPress and general-purpose scripting language used in web development called PHP increased significantly. Projects for WordPress increased by 12.8% (from 17,275 to 19,499), while projects for PHP increased by 8.1% (from 44,333 to 47,937). PHP also ranks as the second most in-demand skill on Freelancer.com in Q4 2022. Top 5 Fast Falling Skills for Q4 2022: CSS3 - down 67.8% Angular - down 58.3% API Integration - down 55.3% Data Extraction - down 53.2% Blog Writing - down 53% Fast 50 Q4 2022 Trends & Analysis Demand shifts from niche IT skills in Q3 to Programming in Q4 While technical skills have always been sought out on the Freelancer platform, global layoffs are causing increases in niche tech skills and unprecedented fluctuations in demand. In the previous quarter, Freelancer uncovered the trend of employers turning to the platform to hire highly skilled IT and tech specialists to support following mass tech layoffs. Tech-related skills made up 40% of the in Q3 2022, with Android App Development, AJAX and API ranking as the three fastest growing skills. A similar trend was also observed in Freelancer’s Fast 50 for Q2 2022 as Software Development ranked as the quarter’s fastest growing skill, up 47% compared to the previous quarter. This quarter, the demand for tech skills continues with employers hiring Programming related skills. Matlab and Mathematica, Web Scraping, C Programming and Python experienced the highest percentage growth for programming skills in this quarter’s index. Other increases include C# Programming up by 11.2% (from 5,986 to 6,657), JavaScript up by 9% (from 17,439 to 19,010) and PHP up by 8.1% (from 44,333 to 47,937). On the other hand, application development saw a decrease in demand in Q4 2022. Jobs requiring skills in Angular, a platform for building mobile and web applications, decreased by 58.3% (from 1,459 to 608). Projects seeking App Developers dropped by 52.2% (from 1,196 to 571), while projects for Android App Development fell by 49.4% (from 1,948 to 984). “Mass layoffs in tech are causing ripple effects as companies scramble to plug skills gaps within their organisations. We’re observing this in waves. As the tech giants lay off staff, we’re seeing employers lean on freelancers for support with tech-related skills. Last quarter, web and app development was in-demand, but this demand has now shifted to programming with increases across the board for many programming language jobs. In 2023, we can expect to see more demand for tech related skills on Freelancer as layoffs continue and employers look to hire on-demand freelancers,” said Barrie. Generative AI leads to spike in Machine Learning Jobs The second half of 2022 saw significant leaps in Artificial Intelligence and Machine Learning. Public access to powerful generative AI tools - such as Stable Diffusion, Dall-E, OpenAI’s GPT-3 and ChatGPT - which are now changing the way designers design and writers write. This is now bleeding into other business areas. Since the release of Chat GPT on November 30th 2022, there have been 26 jobs posted on Freelancer in December that aim to harness the power of generative AI. Many of these projects are seeking AI and Machine Learning experts to help create chatbots, assemble GPT-3 and Stable Diffusion workflows when transcribing video, and integrating Chat GPT-3 to websites. As a reaction to these new technologies, there has been an increase in Machine Learning jobs in Q4 - up by 26.6% (from 2,215 to 2,809). Projects for Machine Learning, AI and Deep Learning are only expected to increase as more businesses become aware of these tools and their potential to integrate them across their business. “There has been an absolutely transformational step that has happened in the last few months with Artificial Intelligence, Machine Learning and Deep Learning. Any creative task man can do, AI can or will be able to do better. Leaps in AI will affect every facet of business. Not just in years, but potentially within months. Companies, businesses and startups are taking notice and exploring ways of harnessing these new tools,” said Barrie. Search Engine Optimisation (SEO) jobs continue surge, Search Engine Marketing (SEM) bounce back from Q3 slump The first expense most companies cut in a downturn is paid advertising. In Q3, Freelancer observed a shift in advertising behavior as employers turned away from paid advertising or SEM projects and began hiring freelancers for more traditional marketing or SEO projects. In this quarter, we’re seeing these companies turn back to SEM and Google Adwords, as well as continue their efforts to improve their SEO. Jobs for Google Adwords increased by 21.4% (from 2,221 to 2,697), while Web Search jobs grew by 15.8% (from 4,111 to 4,763) and SEM-related projects increased by 12.9% (from 1,597 to 1,804). For freelancers, projects relating to SEM are some of the highest paying job types on the platform. On average, Search Engine Marketing jobs pay US$2,231 per project. SEO jobs also pay relatively high on the platform with an average of US$1,704 per project. The areas that did see a noticeable decrease in jobs posted in Q4 2022 compared to Q3 were Creative Design (down by 48.2%, from 1,309 to 677), Content Creation (down by 41.9%, from 1,181 to 686) and Advertisement Design (down by 38.6%, from 1,754 to 1,077). 2022 Fast 50 Reports track major crash in Bitcoin, NFT and Ethereum Each quarterly edition of the Fast 50 Index for 2022 has tracked the rapid rise and fall of freelance crypto and NFT related jobs. At the beginning of the year, the Q1 2022 saw projects for NFTs and NFT-related skills, such as Caricature & Cartoon Design, rank as the fastest growing skills on the platform growing by 30% compared to the previous quarter. During this same period, jobs for Bitcoin were down heavily by 31.1% and jobs for Ethereum began to fall by 23.9%. Q2 2022 saw projects for NFTs shift from the fastest growing jobs on the platform to the fastest falling, with a percentage decrease of 48.9% compared to the previous quarter. Jobs for Bitcoin also fell by 48%, while Ethereum and Blockchain projects fell by 33.9% and 32.9% respectively. Smart Contracts, NFT and Ethereum were amongst the fastest falling in Q3 2022, with most project numbers being cut in half during the quarter. Solidity, high-level language for implementing smart contracts, and Smart Contracts were the top fastest fallers, decreasing by 56.8% and 49.6% respectively. A comparison between Q4 2021 and Q4 2022 demonstrates how quickly these jobs have fallen in popularity from their dominance a year ago. NFTs, down by 75.4% (from 2,045 to 503), and Bitcoin, also down by 74.9% (from 1,518 to 381), took out the top spot for fastest falling project category year-on-year. These were followed by Ethereum, down 73.8% (from 2,340 to 613) and Solidity, down by 69.1% (from 1,988 to 614). ##### Freelancer Fast 50 The Freelancer Fast 50 index is the world’s largest forward indicator of trends in online jobs related to industries, technologies, products, and companies. The data is based on 372,000 jobs posted to the Freelancer platform between 1st October to 31st December 2022. Fast 50 Quarterly Index – Q4 2022 Fast 50 - Q4 Year-on-Year Comparison ###### About Freelancer.com Twelve-time Webby award-winning Freelancer.com is the world's largest freelancing and crowdsourcing marketplace by total number of users and projects posted. More than 63 million registered users have posted over 22.1 million projects and contests to date in over 2,000 areas as diverse as website development, logo design, marketing, copywriting, astrophysics, aerospace engineering and manufacturing. Freelancer owns Escrow.com, the leading provider of secure online payments and online transaction management for consumers and businesses on the Internet with over US$5 billion in transactions secured. Freelancer also owns Freightlancer & Loadshift, enterprise freight marketplaces with over 550 million kilometers of freight posted since inception. Freelancer Limited is listed on the Australian Securities Exchange under the ticker ASX:FLN and is quoted on OTCQX Best Market under the ticker FLNCF. Forward-looking statements This document contains certain "forward-looking statements". The words "anticipate", "believe", "expect", "project", "forecast", "estimate", “outlook”, “upside”, "likely", "intend", "should", "could", "may", "target", "plan" and other similar expressions are intended to identify forward-looking statements. Indications of, and guidance on, future earnings and financial position and performance, including Freelancer’s FY22 outlook, are also forward-looking statements, as are statements regarding Freelancer’s plans and strategies and the development of the market. Such forward-looking statements are not guarantees of future performance and involve known and unknown risks, uncertainties and other factors, many of which are beyond the control of Freelancer, which may cause actual results to differ materially from those expressed or implied in such statements. Freelancer cannot give any assurance or guarantee that the assumptions upon which management based its forward-looking statements will prove to be correct or exhaustive beyond the date of its making, or that Freelancer's business and operations will not be affected by other factors not currently foreseeable by management or beyond its control. Such forward-looking statements only speak as at the date of this announcement and Freelancer assumes no obligation to update such information. The release, publication or distribution of this document in jurisdictions outside Australia may be restricted by law. Any failure to comply with such restrictions may constitute a violation of applicable securities laws. Contact Details Marko Zitko +61 404 574 830 mzitko@freelancer.com Sebastian Siseles +1 415-801-2271 sebastian@freelancer.com

January 04, 2023 12:55 PM Eastern Standard Time

Healthcare