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Completed Redwood Genome Sequence Reveals Genes for Climate Adaptation and Offers Insights into Genetic Basis for Survival

Save the Redwoods League

Save the Redwoods League, University of California, Davis, Johns Hopkins University, University of Connecticut and Northern Arizona University today announced new research that identifies the makeup of the coast redwood and giant sequoia genomes. The information helps scientists and conservationists better understand the genetic basis for these species’ ability to adapt to their changing environments. Through comparative analysis, the research also indicates that the coast redwood genome evolved from a single ancestral species. Today’s announcement follows the official publication of the coast redwood genome research this week in G3: Genes, Genomes, Genetics. The researchers previously made available the completed giant sequoia genome sequence, published in G3 in November 2020. The coast redwood and giant sequoia genome sequence data is available to the scientific community on Neale Lab’s UC Davis website. “It’s remarkable how far genomics research has come since we undertook this challenge in 2017,” said David Neale, Ph.D., plant sciences professor emeritus at UC Davis and lead author on the new coast redwood genome research. “Our work on the coast redwood and giant sequoia genomes will enable us to develop modern genetic tools that can be used in the restoration and conservation of these ecologically important tree species.” The League and its research partners launched the Redwood Genome Project in 2017. Project partners outlined an ambitious plan to fully sequence the coast redwood and giant sequoia genomes for the first time, using new conifer genetic sequencing techniques. The genomic resources and screening tools that can now be developed will allow researchers to quickly assess evolutionary adaptive potential in these forests and ultimately inform forest restoration and management plans. The Coast Redwood Genome The coast redwood is the world’s tallest tree, and its genome is among the most complex sequenced. Nearly nine times larger than the human genome, it is also the second-largest genome sequenced. The redwood genome has 26.5 billion base pairs of DNA, and it is hexaploid, meaning redwoods have six sets of chromosomes. Humans have 3 billion base pairs of DNA and are diploid, with two sets of chromosomes. When comparing the coast redwood genome sequence to that of other conifer species, researchers found hundreds of gene families that are unique to the coast redwood. Many of these are genes that help the trees respond to stress and play a role in resistance to fungal disease, detoxification, repair after injury and the synthesis of flavonoids, which help fight stress on the cellular level. The new research also sheds additional light on the origin of the rare and large hexaploid genome of the coast redwood. Multiple genes exist in triplicate, and those copies share more similarities to each other than to the sequences of other species. This analysis supports the hypothesis that the redwood genome originated from a single ancestral species (autopolyploidy), rather than through hybridization with other conifer species. The Giant Sequoia Genome The giant sequoia is the world’s largest tree species and among the oldest on the planet. As reported by the research team in November 2020, its genome contains 8.125 billion base pairs of DNA. Similar to the human genome, the giant sequoia genome is diploid. The reference genome produced for this study represents the first genome sequenced in the Cupressaceae family, and it lays a foundation for using genomic tools to aid in giant sequoia conservation and management. The genomes of conifers are three to 10 times larger than the human genome. They are highly repetitive and complex. The first conifer genomes ever sequenced were the Norway spruce in 2013 and loblolly pine in 2014, 10 years after the human genome was completed. Sequencing conifer genomes was not previously feasible due to economic and technological limitations. With technological advancements that also reduced the cost, 10 conifer genomes have now been sequenced, including the coast redwood and giant sequoia. The reference genome sequences of coast redwood and giant sequoia enabled the preliminary identification of genes that determine drought-related traits and those that determine adaptation to the environment. These discoveries are reported in papers published in The Plant Journal and Genes. About the Redwood Genome Project Save the Redwoods League has provided strategic guidance and funding for the Redwood Genome Project specifically to inform forest restoration and stewardship activities that will maintain the adaptive genetic diversity of the coast redwood and giant sequoia forests. In the last 160 years, commercial logging and clearcutting claimed 95% of the coast redwood range and about one-third of the giant sequoia range. In 2020, an estimated 10% to 14% of giant sequoia died from high-intensity wildfires, and in some areas, the seedbank also died. Two wildfires also burned through large sections of the giant sequoia range in 2021, and mortality from those is currently estimated to impact another 5% of the mature trees. As a result, both forests have experienced significant losses in total acreage and potentially a loss of genetic diversity as well. With these significant impacts to both populations, the League is leading restoration projects in both forest ranges. It aims to use this and future genetic research to inform efforts to restore and maintain genetic diversity and bolster the resilience of these species in the face of rapid, unprecedented environmental change. “This ambitious scientific research provides a critical foundation for the League and the entire redwoods community. It will ultimately help us understand the incredible range of responses that coast redwood and giant sequoia species have exhibited in the face of climate change and how native genetic diversity has informed these responses,” says Joanna Nelson, Ph.D., director of science and conservation planning for Save the Redwoods League. “The Redwood Genome Project helps us see, for the first time, the full genetic diversity that has allowed these forests to adapt and survive for millennia — and could protect them against a suite of conditions they have never experienced.” The Redwood Genome Project is made possible by Save the Redwoods League, University of California, Davis, Johns Hopkins University, University of Connecticut and Northern Arizona University. Generous donors of Save the Redwoods League have contributed more than $1 million to the project through Forever Forest: The Campaign for the Redwoods, including a significant lead gift from Ralph Eschenbach and Carol Joy Provan. In addition, genomic services companies Illumina, Oxford Nanopore Technologies and Dovetail Genomics contributed in-kind. To learn more about and support this groundbreaking initiative, visit the League’s website at SaveTheRedwoods.org/Genome. *** To schedule an interview, contact Robin Carr at (415) 971-3991 or redwoods@landispr.com. Save the Redwoods League One of the nation’s longest-running conservation organizations, Save the Redwoods League has been protecting and restoring redwood forests since 1918. The League has connected generations of visitors with the beauty and serenity of the redwood forest. The nonprofit’s 29,000 members have enabled the organization to protect more than 216,000 acres of irreplaceable forest in 66 local, state and national parks and reserves. For information, please visit SaveTheRedwoods.org. University of California, Davis UC Davis is a public institution, land-grant university and pioneer in interdisciplinary problem-solving. Its four colleges, five professional schools, more than 100 academic majors and 90 graduate programs make it the most comprehensive of all the University of California campuses. Johns Hopkins University Johns Hopkins is America’s first research university. For more than 140 years Johns Hopkins has been a world leader in both teaching and research, with nine academic divisions — the Krieger School of Arts and Sciences, the Whiting School of Engineering, the Bloomberg School of Public Health, the Carey Business School, the Peabody Institute, the Paul H. Nitze School of Advanced International Studies, and the schools of Medicine, Nursing, and Education — plus the Applied Physics Laboratory, a nonacademic division that supports national security and pursues space science. The University of Connecticut The University of Connecticut is a national leader among public research universities, with more than 32,000 students seeking answers to critical questions in classrooms, labs, and the community. A culture of innovation drives this pursuit of knowledge throughout the University’s network of campuses. Connecticut’s commitment to higher education helps UConn attract students who thrive in the most competitive environments, as well as globally renowned faculty members. Our school pride is fueled by a history of success that has made us a standout in Division I athletics. UConn fosters a diverse and vibrant culture that meets the needs and seizes the opportunities of a dynamic global society. Northern Arizona University Northern Arizona University is a high-research institution providing exceptional educational opportunities in Arizona and beyond. NAU delivers a student-centered experience to its nearly 30,000 students in Flagstaff, statewide and online through rigorous academic programs in a supportive, inclusive and diverse environment. Dedicated, world-renowned faculty help ensure students achieve academic excellence, experience personal growth, have meaningful research opportunities and are positioned for personal and professional success. ### Contact Details Landis Communications Inc. Robin Carr +1 415-971-3991 redwoods@landispr.com Company Website https://www.savetheredwoods.org/

December 16, 2021 12:15 AM Pacific Standard Time

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Variational AI Partners with the University of British Columbia and adMare BioInnovations to Develop COVID-19 Therapeutic

Variational AI

Variational AI, developer of state-of-the-art generative AI technology to redefine the economics of drug development by accelerating the discovery of novel and optimized small molecule therapeutics, today announced the company has generated and ordered compounds for validation in partnership with the University of British Columbia (UBC) and adMare BioInnovations to develop a novel SARS-CoV-2 Main Protease (3CLpro) inhibitor. The therapeutic is intended to be efficacious against the wild type and current variants of concern, including Delta and potentially Omicron, in the form of an antiviral pill. The COVID-19 drug discovery program is funded by Canada’s Digital Technology Supercluster, which is supported by the Canadian Ministry of Innovation, Science and Industry. “The Variational AI team is honored to partner with the University of British Columbia and adMare BioInnovations to work to address this most urgent medical need,” said Handol Kim, co-founder and CEO, Variational AI. “As society continues to grapple with COVID-19 variants, it is more important than ever to leverage the power of machine learning to accelerate our drug discovery efforts.” Variational AI has trained its generative AI algorithm on a large amount of COVID-19 data to generate new molecules and has ordered a number of compounds to be synthesized that are predicted to be potent and safe with fewer side effects. Variational AI uses a generative model known as Variational Autoencoder (VAE), which is able to optimize molecular properties more quickly and uses data far more efficiently. The company intends to license the antiviral compound to a partner to accelerate progress and get the therapeutics into clinics sooner. “We are proud to support Variational AI’s innovative approach to discovering an effective therapeutic for COVID-19,” said Sue Paish, CEO of the Digital Technology Supercluster. “While vaccines offer the first and best line of defense against COVID-19, the global community needs as many therapeutic options as possible to prevent fatalities and improve patient outcomes.” Generally, pills can be manufactured, distributed and stored more easily and cost-effectively than vaccines and are particularly well-suited to treat people in developing countries. In addition to COVID-19 and its variants, the resulting therapeutic may also be efficacious against other coronaviruses. “Our lab is committed to remaining at the forefront of applying computational methods to discover COVID-19 therapeutics, and our collaboration with Variational AI to leverage the company’s powerful AI adds a promising pipeline of novel and potent SARS-CoV-2 Main Protease inhibitors to the arsenal of antiviral options,” said Artem Cherkasov, Ph.D., professor of medicine, University of British Columbia. About Variational AI Variational AI uses state-of-the-art machine learning in a data-efficient method to rapidly generate novel and diverse compounds that are optimized for multiple properties to avoid the most common causes of drug attrition and increase clinical probability of success. Variational AI works with leading biopharmaceutical partners and is developing its own internal pipeline. To learn more, visit https://variational.ai. Contact Details Sage Morander +1 401-490-9700 variationalai@svmpr.com Company Website https://variational.ai/

December 15, 2021 10:00 AM Eastern Standard Time

Oncotelic’s Dr. Anthony Maida to Present at 2nd Annual TGF-β for Immuno-Oncology Drug Development Summit in January 2022

Oncotelic Therapeutics

Oncotelic Therapeutics, Inc. ("Oncotelic" or the "Company") (OTCQB:OTLC), a leading developer of TGF-β therapeutics for oncology and virology, today announced that the Company’s Chief Clinical Officer and Board Director, Dr. Anthony Maida, will present at the upcoming 2 nd Annual TGF-β for Immuno-Oncology Drug Development Summit ( tgf-beta-summit.com ), which will take place virtually from January 25, 2022 to January 27, 2022. “There is significant worldwide interest in the clinical application of anti-TGF-β inhibitors, in combination with checkpoint inhibitors, as well as other immuno-oncology and chemotherapeutic options. We look forward to sharing the clinical promise of OT-101 in this setting.” noted Dr. Anthony Maida, Chief Clinical Office – Translational Medicine. TGF-β has been recognized by drug developers, for many years, as holding vast therapeutic potential due to its vital role in cell functioning and signaling. But its complex nature and its ability to be both tumor promoting and tumor suppressing has presented many obstacles for the industry. However, the field appears to be at a tipping point at present, with more candidates moving through clinical evaluation, pointing to an explosion of new data on the way. “I am excited that we have the opportunity to join other professionals in the field in January to explore novel insights into targeting TGF-β from discovery through clinical testing, and to learn from fellow colleagues such as Genentech, AbbVie, Takeda, and Mestag Therapeutics.” noted Dr. Vuong Trieu, CEO and Chairman of Oncotelic. OT-101 is a first-in-class anti-TGF-β ribonucleic acid (“RNA”) therapeutic that has exhibited single agent activity in relapsed/refractory cancer patients in multiple clinical trials. OT-101 has also demonstrated activity against the SARS-CoV-2 virus, the virus that causes COVID-19, and is currently being evaluated in the Company’s C001 clinical trial against hospitalized severe COVID-19 patients. Both tumor cells and SARS-Cov-2 induce TGF-β as part of their immune evasion mechanism. Consequently, inhibiting TGF-β through therapeutic use of OT-101 carries significant potential to help both cancer and COVID patients in the future. Recent analyst report for Oncotelic can be accessed here: http://www.hillsresearch.com/wp-content/uploads/2021/12/OTLC-3Q21.pdf Recent Dr. Anthony Maida interview on our clinical program can be accessed here: https://www.asbestos.com/news/2021/12/07/mesothelioma-trial-covid-19-drug/ About Oncotelic Therapeutics Oncotelic Therapeutics, Inc. (f/k/a Mateon Therapeutics, Inc.) ("Oncotelic"), was formed in the State of New York in 1988 as OXiGENE, Inc., was reincorporated in the State of Delaware in 1992, and changed its name to Mateon Therapeutics, Inc. in 2016, and Oncotelic Therapeutics, Inc. in November 2020. Oncotelic is an artificial intelligence driven immuno-oncology company with a robust pipeline of first in class TGF-β immunotherapies for late stage cancers such as gliomas, pancreatic cancer and melanoma. OT-101, the lead immuno-oncology drug candidate of Oncotelic, is a first-in-class anti-TGF-β RNA therapeutic that exhibited single agent activity in relapsed/refractory cancer patients. OT-101 also has shown activity against SARS-CoV-2 and has completed a phase 2 trial against COVID-19 with data cleaning and datalock ongoing. Oncotelic is seeking to leverage its deep expertise in oncology drug development to improve treatment outcomes and survival of cancer patients with a special emphasis on rare pediatric cancers. Oncotelic also has rare pediatric designation for DIPG (OT-101), melanoma (CA4P), and AML (OXi 4503). The Company also acquired PointR Data Inc. ("PointR") in November 2019. For more information, please visit www.oncotelic.com Oncotelic Therapeutics, Inc. ("Oncotelic" or the "Company") (OTCQB:OTLC), a leading developer of TGF-beta therapeutics for oncology and virology This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this communication regarding strategy, future operations, future financial position, prospects, plans and objectives of management are forward-looking statements. Words such as "may", "expect", "anticipate", "hope", "vision", "optimism", "design", "exciting", "promising", "will", "conviction", "estimate," "intend," "believe", "quest for a cure of cancer", "innovation-driven", "paradigm-shift", "high scientific merit", "impact potential" and similar expressions are intended to identify forward-looking statements. Forward looking statements contained in this press release include, but are not limited to, statements about future plans, the progress, timing, clinical development, scope and success of future clinical trials, the reporting of clinical data for the company's product candidates and the potential use of the company's product candidates to treat various cancer indications. Each of these forward-looking statements involves risks and uncertainties, and actual results may differ materially from these forward-looking statements. Many factors may cause differences between current expectations and actual results, including unexpected safety or efficacy data observed during preclinical or clinical studies, clinical trial site activation or enrollment rates that are lower than expected, changes in expected or existing competition, changes in the regulatory environment, failure of collaborators to support or advance collaborations or product candidates and unexpected litigation or other disputes. These risks are not exhaustive, the company faces known and unknown risks, including the risk factors described in the Company's annual report on Form 10-K filed with the SEC on April 15, 2021 and in the company's other periodic filings. Forward-looking statements are based on expectations and assumptions as of the date of this press release. Except as required by law, the company does not assume any obligation to update forward-looking statements contained herein to reflect any change in expectations, whether as a result of new information future events, or otherwise. Contact Details Amit Shah ashah@oncotelic.com Company Website https://www.oncotelic.com

December 14, 2021 09:01 AM Eastern Standard Time

Series of Infographics From Quidel Corporation Helps Educate Consumers on the Characteristics, Warning Signs and Prevalence of Lyme Disease

Quidel Corporation

With Lyme disease being identified in record numbers throughout the country, Quidel releases a series of consumer-friendly infographics to help educate Americans on its characteristics, warning signs, seasonality and areas of prevalence. The infographics can be found at LymeDiseaseAnswers.com. “Lyme disease afflicts nearly 480,000 Americans each year; so people are rightfully concerned about where it is most pervasive, how to avoid getting it, and what to do if you think you may have been bitten by an infected tick,” said Judi Tilghman, Ph.D., vice president of technology assessment at Quidel Corporation. “These infographics provide the information people are seeking in an easy-to-understand manner, and we encourage anyone who spends any time outdoors to educate themselves on this vitally important topic.” One infographic, for example, displays the early warning signs of Lyme disease—which could include headache, fatigue, a bulls-eye rash and muscle aches—while a second infographic depicts such late-stage symptoms as nerve pain, shortness of breath, brain fog and heart palpitations. There is an infographic showing the relative sizes of the larva, nymph and adult ticks; while still another infographic illustrates the evolution of these ticks through spring, summer, fall and winter. There is also a map showing those states where various types of ticks are most prevalent. Lyme disease can strike anyone of any age, especially those who spend time in wooded or grassy areas or who play sports on grass fields in high-risk areas of the country. The challenge is that unlike a mosquito bite where people know immediately if they have been bitten, deer ticks that may carry Lyme disease are tiny—the size of a poppy seed—and symptoms may not appear for two to six weeks. That makes it critically important that anyone who spends time outdoors in heavily wooded areas—hikers, hunters, campers—or travels to such places be particularly vigilant and educated. Quidel is the diagnostic health care manufacturer behind the industry’s most rapid and reliable in-office test for Lyme disease, the Sofia® 2 Lyme FIA test. This revolutionary test provides the patient and physician with indicative results within 15 minutes, as opposed to days, which has historically been the norm (and during which time organisms can spread and become systemic). It can be performed in the privacy of a doctor’s office or local clinic; and it is the only test that can get results from a simple finger prick of blood. In addition to the infographics, LymeDiseaseAnswers.com contains answers to frequently asked questions, the latest statistics and clinical research taking place regarding the disease, and links to additional resources on the subject. Also housed on the site is a series of attention-grabbing educational videos called “Quick Takes” that help consumers and health care professionals alike enhance their knowledge of Lyme disease by providing the information and up-to-the-minute data needed to confront this disease quickly and clearly. About Quidel Corporation Quidel Corporation (Nasdaq: QDEL) is a leading manufacturer of diagnostic solutions at the point of care, delivering a continuum of rapid testing technologies that further improve the quality of health care throughout the globe. An innovator for over 40 years in the medical device industry, Quidel pioneered the first point-of-care test for influenza in 1999 and was the first to market a rapid SARS-CoV-2 antigen test in the U.S. Under trusted brand names, SofiaÂ®, SolanaÂ®, LyraÂ®, TriageÂ® and QuickVueÂ®, Quidel's comprehensive product portfolio includes tests for a wide range of infectious diseases, cardiac and autoimmune biomarkers, as well as a host of products to detect COVID-19. Quidel's mission is to provide patients with immediate and frequent access to highly accurate, affordable testing for the good of our families, our communities and the world. For more information about Quidel, visit quidel.com. # # # Contact Details Jim Yeager +1 818-264-6812 jim@breakwhitelight.com Company Website http://Quidel.com

December 14, 2021 06:00 AM Pacific Standard Time

Kadimastem Announces the Approval of a 4M NIS ($1.29M) Budget from the Israel Innovation Authority

Kadimastem

Kadimastem Ltd. (TASE: KDST), a clinical stage cell therapy company developing a treatment for ALS and a potential cure for diabetes, has received a grant of NIS 1.6 million ($500K), 40% of the approved budget of NIS 4 million ($1.29M) from the Israel Innovation Authority (IIA). This brings the total amount of financing raised by Kadimastem in 2021 to NIS 51.6 million ($16 M). As Kadimastem intends to submit the IND for the Phase IIa clinical study before the end of 2022, the IIA funding will be used to scale up the production of a frozen, off-the-shelf product of AstroRx® in preparation for the trial. Using large reactors and special tools, hundreds of millions of high-quality astrocyte cells, the brain supporting cells that comprise AstroRx®, will be produced for the clinical trial, as well as for future commercialization purposes for the benefit of the hundreds of thousands of ALS patients worldwide. Kadimastem has already completed a Phase I/IIa clinical trial ( ClinicalTrials.gov Identifier: NCT03482050 ). This trial was the first of its kind in the world, whereby the supporting cells of the central nervous system (AstroRx®), produced by the company, were injected into the spinal fluid of patients, in a standard lumbar puncture procedure. Five ALS patients were injected with 100 million cells and five patients were injected with 250 million cells. The results of both doses demonstrated a high safety profile. No serious treatment-related side effects were reported and no side effects limiting the treatment dose were found. In order to determine initial efficacy, an analysis was performed comparing the rate of disease progression according to the ALSFRS-R index in the pre-treatment follow-up period and the post-treatment follow-up period. It was found that with both doses the rate of disease progression slowed significantly during the three months following injection. In light of these clinical trial results, in the next study, the company intends to examine if dosing every three months with the cellular off-the-shelf AstroRx® product prolongs the therapeutic effect. Kadimastem CEO Asaf Shiloni said, "In the past year, Kadimastem has experienced an unprecedented show of support from both existing and new investors. Today’s grant by the Israeli Innovation Authority is another strong endorsement of the company’s important work in developing an improved therapeutic treatment for the millions suffering from debilitating neurological diseases. Kadimastem is at an exciting turning point and this grant supports us with the necessary resources to advance the plans for the quantitative production of the company's flagship product - AstroRx®. In other words, after this past year’s fund raising, we now have the capital to create increased quantities of brain supporting cells, enough to truly make a big difference in helping the hundreds of thousands of ALS patients worldwide." Chief Scientist of Kadimastem Professor Michel Revel said, "We thank the Israel Innovation Authority for its continued support and for further helping Kadimastem to proceed on this very worthwhile journey." About Kadimastem: Kadimastem is a clinical stage cell therapy company, developing and manufacturing "off-the-shelf", allogeneic, proprietary cell products based on its technology platform for the expansion and differentiation of Human Embryonic Stem Cells (hESCs) into functional cells. AstroRx®, the company's lead product, is an astrocyte cell therapy in clinical development for the treatment for ALS. IsletRx is the company's second product in development. IsletRx is comprised of functional, insulin producing, pancreatic islet cells intended to treat and cure patients with insulin-dependent diabetes. IsletRx demonstrated safety and efficacy in a proof-of-concept preclinical study. An INTERACT meeting took place with the FDA on October 7, 2021, where the diabetes treatment program was discussed, and the company received directions how to prepare its Pre-IND submission. In November 2021, the company announced its intention to list on NASDAQ. Kadimastem was founded by Professor Michel Revel, CSO of the company and Professor Emeritus of Molecular Genetics at the Weizmann Institute of Science. Professor Revel received the Israel Prize for the invention and development of Rebif®, a multiple sclerosis blockbuster drug sold worldwide. Kadimastem is traded on the Tel Aviv Stock Exchange (TASE: KDST). Forward Looking Statement: This document may include forward-looking information as defined in the Securities Law, 5728 – 1968. Forward-looking information is uncertain and mostly is not under the Company's control and the realization or non-realization of forward-looking information will be affected, among other things, by the risk factors characterizing the Company's activity, as well as developments in the general environment and external factors affecting the Company's activity. The Company's results and achievements in the future may differ materially from any presented herein and the Company makes no undertaking to update or revise such projection or estimate and does not undertake to update this document. This document does not constitute a proposal to purchase the Company's securities or an invitation to receive such offers. Investment in securities in general and in the Company in particular bears risks. One should consider that past performance does not necessarily indicate performance in the future. Contact Details Asaf Shiloni +972 73-797-1613 s.herzl@kadimastem.com Company Website https://www.kadimastem.com/

December 13, 2021 07:00 AM Eastern Standard Time

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Centre for Neuro Skills Introduces Telerehabilitation: Instant Access to Therapies, Staff and CNS Physicians

Centre for Neuro Skills

Centre for Neuro Skills (CNS), a premier provider of treatment for traumatic and acquired brain injury, has introduced telerehabilitation services to offer patients greater flexibility in their therapy program. CNS’ telerehabilitation services offer enhancements beyond its previously offered telehealth program. Since the beginning of 2020, CNS has delivered more than 125,000 hours of telehealth care to patients. Using the RingCentral Video® platform, powered by Zoom, patients receive full rehabilitation at home, virtually access therapies, clinicians and their treatment team from their CNS clinic. “CNS cares about rehabilitation success both in-clinic and at home, and telerehabilitation therapies focus on building life skills that lead to independence,” said Chris Persel, Regional Director of Clinical Services and Director of Behavior Programming at Centre for Neuro Skills. “Now, in their own environment, patients can work with their therapy team using the telerehabilitation toolkit as a desktop box of essentials to help build memory, cognition, reasoning, dexterity, education and other personal management details.” Therapy in real-time: All treatment modules are provided and vital living skills are taught; in-clinic therapies are replicated in the patient’s home setting and staff can suggest adaptive aids by viewing the home environment; return-to-work scenarios that can be modeled and practiced at home; therapists teach safety skills that patients can practice in real time. Telerehabilitation kit: CNS sends a boxed kit of learning aids to telerehabilitation and some hybrid patients. Included is a user’s guide for navigating RingCentral Video, learning tools, notebooks, a calculator, pens, a water bottle and a desktop whiteboard. Hybrid rehabilitation: Patients can opt for both in-clinic and virtual treatment. Telemedicine: Patients, therapists and families can consult online with physicians. In a recent national survey by the Brain Injury Association of America, telehealth was found to be a highly effective therapy platform. According to the survey of more than 400 providers, 94% of therapists reported that their patients’ recovery progressed using telehealth. About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Centre for Neuro Skills, visit: www.neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership, clinical staff or patients, please contact Robin Carr at (415) 971-3991 or CNS@landispr.com. Contact Details Landis Communications Inc. Robin Carr +1 415-971-3991 cns@landispr.com Company Website https://www.neuroskills.com/

December 10, 2021 06:17 AM Eastern Standard Time

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COMCAST'S INTERNET ESSENTIALS PROGRAM AND SERJOBS ANNOUNCE TECHNICAL SKILLS TRAINING PARTNERSHIP AND $30,000 DONATION

Comcast Houston

Comcast's Internet Essentials program today announced the award of a $30,000 financial grant and donated 1,000 laptops to SERJobs, whose mission is to help individuals from low-income communities transform their lives through education training, employment, and financial empowerment services. The grant and donation are part of a new partnership to fund technical skills training and readiness certifications for clients of SERJobs. This program will offer digital skills training opportunities, including Microsoft Office, PowerPoint, Excel and professional development. “SERJobs is excited to celebrate 10 years of Comcast's Internet Essentials program,” said Sheroo Mukhtiar, CEO, SERJobs. “The Workforce Development Rally highlights the importance of digital literacy in our increasingly virtual world—especially as technology and the needs of our economy evolve. We are grateful to Comcast for their ongoing partnership and support of SERJobs’ and our members.” The announcement is part of Project UP, Comcast’s comprehensive initiative to advance digital equity and help build a future of unlimited possibilities; and coincides with the 10th anniversary of its Internet Essentials program, which has connected a cumulative total of more than 10 million people to the Internet at home – most for the very first time. Comcast’s expanded eligibility for Internet Essentials, now including all Federal Pell Grant recipients within its service area, will enable even more students to stay connected as they continue to pursue degrees at colleges, universities, and technical schools. “Ten years is a remarkable milestone, signifying an extraordinary amount of work and collaboration with our incredible community partners across Houston,” said Toni Beck, Vice President of External Affairs, Comcast Houston. “Together, we have connected hundreds of thousands of people to the power of the Internet at home, and to the endless opportunity, education, growth, and discovery it provides. Our work is not done, and we are excited to partner with SERJobs to ensure the next generation of leaders in Houston are equipped with the technical training they need to succeed in an increasingly digital world.” Comcast’s top priorities are connecting people to the Internet at home, equipping safe spaces with free WiFi and working with a robust network of nonprofit community organizations, city leaders, and business partners to create opportunities for low-income Americans. As the nation’s largest internet provider, Comcast supports cooperation between communities, businesses and non-profit organizations to enhance digital equity. Comcast’s $1 billion commitment will include investments in several critical areas, including: additional support for the Lift Zone initiative, which establishes free WiFi access in 50 community centers in Houston, and 1,000+ community centers nationwide, for students and adults by the end of 2021; new laptop and computer donations; over $100,000 in digital equity grants for local Houston nonprofit community organizations to create opportunities for low-income Houstonians – particularly in media, technology, and entrepreneurship; and continued investment in the company’s landmark Internet Essentials program. Project UP & Comcast’s $1 Billion Commitment to Advancing Digital Equity: For over a decade, connecting more people to the Internet and the technology they need to participate and excel in an increasingly digital world has been a core focus for the company. Looking toward the next ten years, Comcast is building on that foundation and expanding its impact through Project UP, a comprehensive initiative to advance digital equity and help build a future of unlimited possibilities. Backed by a $1 billion commitment to reach 50 million people, Project UP encompasses the programs and community partnerships across Comcast, NBCUniversal, and Sky that connect people to the Internet, advance economic mobility and open doors for the next generation of innovators, entrepreneurs, storytellers, and creators. For more information on Project UP and the latest news on efforts to address digital inequities visit https://corporate.comcast.com/impact/project-up. About Comcast Corporation Comcast Corporation (Nasdaq: CMCSA) is a global media and technology company that connects people to moments that matter. We are principally focused on broadband, aggregation, and streaming with over 57 million customer relationships across the United States and Europe. We deliver broadband, wireless, and video through our Xfinity, Comcast Business, and Sky brands; create, distribute, and stream leading entertainment, sports, and news through Universal Filmed Entertainment Group, Universal Studio Group, Sky Studios, the NBC and Telemundo broadcast networks, Peacock, NBC News, NBC Sports, Sky News, and Sky Sports; and provide memorable experiences at Universal Parks and Resorts in the United States and Asia. Visit www.comcastcorporation.com for more information. About SERJobs: SERJobs Houston, a regional affiliate of SER Jobs for Progress National, Inc., is a nonprofit organization empowering individuals to transform their lives through education, training, employment, and financial empowerment services. Founded in 1965 as a volunteer job bank for Hispanic veterans, SERJobs has evolved, and now operates offices in Houston, Galveston and Fort Bend. SERJobs serves individuals in 13 Texas counties and assists more than 4,000 members access better opportunities every year. For more information, visit serjobs.org Contact Details Comcast Foti Kallergis +1 832-986-0196 Foti_Kallergis@comcast.com SERJobs Christi Vasquez +1 832-890-3606 Company Website https://houston.comcast.com/

December 02, 2021 09:01 AM Central Standard Time

Regenerative Medicine Company Vascudyne Closes $10 Million Series A Financing

Vascudyne, Inc.

Investment will support expanded clinical trials of TRUE Graft, establish a commercial GMP manufacturing facility, and further develop the TRUE Tissue platform technology for additional products. Vascudyne, Inc., a biotechnology trailblazer in regenerative medicine, announced today that it has raised $10 million Series A cash financing through a global group of investors. In July, Vascudyne also announced the successful first human use of TRUE™ Graft for hemodialysis access in end-stage renal disease patients. Vascudyne’s early product development and preclinical studies were funded by angel investors. Since incorporation, Vascudyne transferred the regenerative technology, vertically integrated manufacturing, and launched TRUE Graft’s first human use clinical trial. Vascudyne’s TRUE to Nature™ biomaterials are unique and 100% natural. While other regenerative medicine cardiovascular devices contain synthetic polymer-based scaffolds that slowly degrade in the body and may lead to adverse immune response, Vascudyne’s TRUE™ Tissue technology is 100% biological: nothing synthetic or artificial is ever used in the manufacturing process. “We are thrilled that investors share our passion for bringing our TRUE Tissue platform technology to patients worldwide,” shared Rick Murphy, VP of Operations and GM of Vascudyne. “We are scaling up our GMP manufacturing facility to support the expansion of the clinical safety study of our TRUE Graft for hemodialysis access and accelerate new products towards clinical use that are currently in development for multiple cardiovascular applications.” “Closing the Series A finance round is a very exciting milestone for Vascudyne,” said Kem Schankereli, Chief Executive Officer of Vascudyne. “We are gaining momentum and paving the way to being able to supply our TRUE Tissue regenerative material technology to patients in need. The Series A funding provides the needed support to grow the organization so we can continue our clinical trials, expand operations, and translate additional products using our TRUE technology platform from pre-clinical to clinical trials.” Vascudyne licensed its proprietary TRUE Tissue technology developed by world renowned tissue engineering leader Robert Tranquillo, PhD, Distinguished McKnight University Professor, and his colleagues from the University of Minnesota in 2017. The TRUE Graft is not available for commercial sale. About Vascudyne Headquartered in the heart of Medical Alley in Minnesota, Vascudyne is on a mission to improve patient care with regenerative biomaterials that are inspired by nature. Vascudyne, a privately held company founded in 2014, uses the TRUE™ Tissue technology to develop TRUE to Nature™ biomaterials for soft tissue repair and replacement. For more information, please visit https://www.vascudyne.com/. About TRUE Tissue Technology TRUE™ Tissue is developed from cells isolated from donor tissue and is 100% biological. There are no synthetic materials or chemical fixation used, and implanted tissues are completely cell-derived and acellular. The TRUE Tissue technology can be readily shaped into tubes, sheets, and other geometries making it suitable for many soft tissue applications, is mechanically comparable to native tissues, and is a ready to use, off-the-shelf allograft. Forward Looking Statements This announcement contains forward-looking statements. Such statements may include, without limitation, statements identified by words such as "projects," "may," "will," "could," "would," "should," "believes," "expects," "anticipates," "estimates," "intends," "plans," "potential" or similar expressions. These statements relate to future events or Vascudyne’s clinical development programs, reflect management’s current beliefs and expectations and involve known and unknown risks, uncertainties and other factors that may cause Vascudyne’s actual results, performance or achievements to be materially different. Vascudyne undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future presentations or otherwise, except as required by applicable law. Contact Details Vascudyne Sandy Williams, Marketing Director +1 952-412-5975 swilliams@vascudyne.com Company Website https://vascudyne.com/

December 02, 2021 09:23 AM Eastern Standard Time

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UK SMEs forge ahead with cautious optimism as post-pandemic business confidence grows

Stockwood Strategy

Despite lingering anxieties about the pandemic and a variety of economic and commercial issues, the majority of SMEs believe it is now imperative to begin building back from the crisis. They are ready to step up their business investment, with ambitious plans for recruitment, renewal of equipment and machinery, and both domestic and international expansion. Fintech business lender MarketFinance asked 2,000 SME owners across the UK about their outlook for 2022 and beyond, gauging their short and long-term plans for business investment and growth. MarketFinance has today released a comprehensive research report of its findings. Confidence Analysis of the survey results has shown that business confidence amongst SMEs is improving, with many firms now focused on recovery and growth. With pandemic disruptions now largely settled, half of SMEs (48%) expect their turnover to stabilise or to increase over the next 12 months. Similarly, 50% of SMEs expect demand for their products or services to stabilise or to increase over the next six months. MarketFinance’s research has found that the majority of SMEs (63%) expect their business to grow over the next three years Investment With survival mode no longer a necessity and cash flow pressures beginning to ease, the vast majority of SMEs (70%) now feel confident enough to increase business investment over the next 12 months. A quarter of SMEs plan to hire new staff, while 24% expect to purchase new equipment and machinery. When asked how they were factoring borrowing into their investment plans, 23% of SMEs said access to a broader range of borrowing options could enable them to increase investment even further. Borrowing The research findings demonstrate that borrowing will play a key role in recovery and growth with 62% of SMEs saying that prudent borrowing could help them fund growth. However, three quarters (71%) of SMEs do not believe traditional banking products are the most obvious and convenient way to borrow for investment. Despite this lack of alignment between current finance needs and the options available through traditional routes, more than a third of SMEs (37%) are looking to take on new borrowing facilities. Growth With confidence high and a sense of having moved beyond recovery and into a new stage of growth, many businesses are looking forward to seizing a host of opportunities in 2022. Almost all SMEs surveyed (81%) plan to invest in sustainability, while 30% say they are considering merger and acquisition (M&A) activity in the year ahead – more than twice as many as those primarily focusing on organic growth (14%). Over a third of businesses (34%) say they already sell overseas, or have plans to begin doing so. That figure is highest amongst the largest businesses surveyed (turnover between £5m and £6.5m) but even amongst smaller enterprises significant numbers are focused on export. Anil Stocker, CEO at MarketFinance, commented: “ It’s clear that the business environment has shifted and SMEs are looking ahead with a quietly confident and cautiously optimistic view. UK businesses intend to ramp up growth through domestic and international expansion, digital transformation and even M&A activity. But as they reset their post-pandemic goals for a post-pandemic, they’ll need to be confident of their funding base. Given that so many SMEs are looking outside of traditional routes in their search for finance, we’re particularly proud to have been accredited by the British Business Bank as one of the few alternative providers under The Recovery Loan Scheme. Schemes like the RLS are a golden opportunity for SMEs looking to gear up for growth, providing easily accessible funding at a lower cost across a wide range of products. We expect to see a large number of SMEs taking advantage of the scheme over the next 6 months as their growth and expansion efforts gain momentum and they invest in ambitious plans for 2022 and beyond.” About MarketFinance MarketFinance is a fintech business lender which believes that SMEs are building the world. By making finance frictionless, they’re solving the cash flow issues getting in the way of progress. MarketFinance uses smart technology to deliver better access to faster, more affordable finance; with one-to-one help whenever businesses need it. Since 2011, MarketFinance has advanced over £2.6 billion worth of invoices and loans, enabling thousands of UK businesses to bridge today’s funding gaps and fuel tomorrow’s big ambitions. MarketFinance is an accredited Recover Loan Scheme lender and has a wide-reaching network of strategic partners including Barclays Bank UK PLC, Tide, Equals Group and Ebury. MarketFinance is backed by Barclays Bank UK PLC, Mouro Capital, Paul Forster (co-founder of Indeed.com) European venture capital fund Northzone (invested in Klarna, iZettle and Trustpilot), Viola Capital and private equity group MCI Capital (also invested in iZettle, Azimo and Gett). Further information visit: www.marketfinance.com Contact Details MarketFinance Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://marketfinance.com/

December 01, 2021 08:00 AM Eastern Standard Time

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