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Principal Technologies laser focussed on acquiring healthcare tech to launch in North America

Principal Technologies

Jerry Trent, CEO of Principal Technologies joined Steve Darling from Proactive to share insights in a recent interview about the company's focus on healthcare technology companies in Europe. The company aims to identify local champions with exceptional healthcare technologies that are often limited to specific regions. Principal Technologies plans to leverage its access to these opportunities, helping them expand globally and bridge valuation gaps between European assets and the North American market. The company's strategic focus includes businesses with proven technologies and databases of patient information. The goal is to create a conglomerate of participations with synergies to benefit patients and shareholders. Principal Technologies has also acquired a clinical research organization (to facilitate efficient international distribution rights for healthcare tech companies while expanding its database. Trent mentioned that they are actively exploring significant acquisitions in line with their criteria, signaling exciting growth prospects for Principal Technologies in the coming months. The interview revealed the company's commitment to improving healthcare globally, driven by a seasoned team and guided by Liechtenstein's Prince, offering a promising future for the company and its stakeholders. Stay tuned for more updates on Principal Technologies' developments. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

September 13, 2023 02:00 PM Eastern Daylight Time

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Rakovina Therapeutics continues to make progress as company provides corporate update

Rakovina Therapeutics Inc

Rakovina Therapeutics Executive Chairman Jeffery Bacha joined Steve Darling from Proactive to discuss the company's corporate highlights as part of its second-quarter financial report. Bacha highlighted several significant developments for the company during this period: including a publication in the Journal of Clinical Oncology. Rakovina Therapeutics published a paper in the Journal of Clinical Oncology describing pre-clinical data for its lead pre-clinical candidate, kt-3283. This data demonstrates the potential of kt-3283 to treat cancers that are resistant to first-generation PARP inhibitors. This development is crucial as it suggests that Rakovina's compound could address unmet medical needs in the treatment of various treatment-resistant cancers, including Ewing sarcoma. Bacha also said the company presented at the American Association of Cancer Research. The company presented new preclinical in vitro and in vivo data at the annual meeting of the American Association of Cancer Research. This data demonstrated the potential of Rakovina's kt-3000 series in treating treatment-resistant Ewing sarcoma, a rare childhood tumor. The kt-3000 series is a novel class of DNA-damage response inhibitors designed to selectively inhibit two important anti-cancer targets: poly(ADP) ribose polymerase (PARP) and histone deacetylase (HDAC). These developments reflect Rakovina Therapeutics' commitment to advancing innovative treatments for challenging and resistant cancers. The company's research and progress in the field of cancer therapy offer hope for patients and represent significant strides in addressing unmet medical needs. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

September 13, 2023 01:30 PM Eastern Daylight Time

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xCures Platform advances progress on the White House Cancer Moonshot mission to end cancer as we know it.

xCures

xCures, a leader in data-driven cancer solutions, is thrilled to announce that its platform has been highlighted as a new commitment to deliver progress on the White House Cancer Moonshot mission – ending cancer as we know it. The xCures health-data technology platform has been designed to overcome a key challenge for many rare diseases: collecting, organizing, and standardizing comprehensive data from patients across the US. In alignment with the Cancer Moonshot Initiative’s goals to reduce cancer death rates by 50% over the next 25 years, xCures is launching an ambispective natural history study of DMG and DIPG. This study will speed up the identification of patterns that can inform more personalized treatment plans and targeted therapies. xCures will provide access without licensing fees to the data for academic and government researchers. Open access to this valuable resource will accelerate scientific breakthroughs and foster a community actively seeking a cure. “We recognize that collaboration is key to success. Our pledge extends to fostering an ongoing relationship with all stakeholders - patients, families, physicians, researchers, and advocacy organizations,” said Mika Newton, CEO of xCures. “Together, we can create a powerful collective dedicated to advancing the understanding and treatment of DMG DIPG.” DMG and DIPG patients are encouraged to sign up for the study at www.xcures.com/dmg About xCures xCures Inc. operates an AI-assisted platform that automatically retrieves medical records from all sites of care. The (unstructured) data is aggregated and organized into a powerful, always up-to-date care summary that helps cancer patients get the right therapy at the right time. The platform's portals, xINFORM for patients and xDECIDE for providers, facilitate treatment option decisions. The research portal, xUTILITY, generates Real-time, Regulatory-grade, Clinical data (RRC) for studies and decentralized trials. For more information, contact info@xcures.com or visit http://www.xcures.com. Contact Details xCures Inc Patrick van der Valk pvandervalk@xcures.com Company Website https://xcures.com

September 13, 2023 01:04 PM Eastern Daylight Time

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Microban launches Ascera™: a patent-pending, cutting-edge antimicrobial technology inspired by nature

Microban International

Microban International is pleased to introduce its latest ground-breaking technology – Ascera™. This patent-pending, next generation antimicrobial technology uses an active ingredient inspired by nature*, and is designed for use in olefinic polymers and solvent-based coatings. Ascera is sustainable, metal free and less toxic than alternative technologies, and provides the lifelong antimicrobial product protection that Microban is known for around the world. As the global leader in antimicrobial and odor-control technologies, Microban is committed to the development of solutions that support product sustainability by extending their useful lifetimes. Ascera exemplifies the company’s commitment to sustainability by offering lasting product protection while maintaining critical attributes, such as ease of incorporation, safe handling, and good chemical, thermal and UV stability. Ascera will perform for the product’s expected lifetime when applied according to Microban’s standards, effectively inhibiting the growth of odor-causing bacteria to prevent stains and premature aging of the finished product. “Microban has always led the antimicrobial industry with technological innovations that contribute to product sustainability,” said Dr. Souvik Nandi, Vice President of R&D at Microban International. “In the past decade, regulatory and environmental groups have put increasing pressure on many of the antimicrobial chemistries that are currently used. As a result, Microban has invested significant resources in identifying naturally occurring solutions that are more sustainable and effective. We are very proud to roll out Ascera, which represents the culmination of many years of intensive research. This is the first of an exciting series of nature-inspired solutions that we will be launching in the next few years for different market segments and material types.” “As the global leader in antimicrobial, odor-control and surface modification solutions, Microban is always standing at the forefront of the industry. As we work towards our vision of becoming the most trusted brand in ultimate cleanliness and product protection, we want the world to rely on Microban for best-in-class solutions.” Michael Ruby, President of Microban International, said. “Our R&D teams are laser-focused on developing a range of cutting-edge technologies that are nature inspired for the different market sectors we serve. Our partners look to us first for what is next. Ascera will help leading brands to create clean, odor-free and high value end-use products, which their customers will choose to support sustainability and live a clean and refreshing lifestyle." Ascera is available to manufacturers in the U.S. and Asia, along with Microban’s support and expertise. Find out more at https://www.microban.com/antimicrobial-solutions/technologies/ascera and get in touch with a representative today! *The Microban ® technology used in this product is similar to acids found in nature and is used in multiple consumer product applications. Contact Details Audrey Jestin at kdm communications limited, St Neots, UK +44 1480 405333 ideas@kdm-communications.com Company Website https://www.microban.com/

September 13, 2023 10:00 AM Eastern Daylight Time

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Microban launches Ascera™: a patent-pending, cutting-edge antimicrobial technology inspired by nature

Microban International

Microban International is pleased to introduce its latest ground-breaking technology – Ascera™. This patent-pending, next generation antimicrobial technology uses an active ingredient inspired by nature*, and is designed for use in olefinic polymers and solvent-based coatings. Ascera is sustainable, metal free and less toxic than alternative technologies, and provides the lifelong antimicrobial product protection that Microban is known for around the world. As the global leader in antimicrobial and odor-control technologies, Microban is committed to the development of solutions that support product sustainability by extending their useful lifetimes. Ascera exemplifies the company’s commitment to sustainability by offering lasting product protection while maintaining critical attributes, such as ease of incorporation, safe handling, and good chemical, thermal and UV stability. Ascera will perform for the product’s expected lifetime when applied according to Microban’s standards, effectively inhibiting the growth of odor-causing bacteria to prevent stains and premature aging of the finished product. “Microban has always led the antimicrobial industry with technological innovations that contribute to product sustainability,” said Dr. Souvik Nandi, Vice President of R&D at Microban International. “In the past decade, regulatory and environmental groups have put increasing pressure on many of the antimicrobial chemistries that are currently used. As a result, Microban has invested significant resources in identifying naturally occurring solutions that are more sustainable and effective. We are very proud to roll out Ascera, which represents the culmination of many years of intensive research. This is the first of an exciting series of nature-inspired solutions that we will be launching in the next few years for different market segments and material types.” “As the global leader in antimicrobial, odor-control and surface modification solutions, Microban is always standing at the forefront of the industry. As we work towards our vision of becoming the most trusted brand in ultimate cleanliness and product protection, we want the world to rely on Microban for best-in-class solutions.” Michael Ruby, President of Microban International, said. “Our R&D teams are laser-focused on developing a range of cutting-edge technologies that are nature inspired for the different market sectors we serve. Our partners look to us first for what is next. Ascera will help leading brands to create clean, odor-free and high value end-use products, which their customers will choose to support sustainability and live a clean and refreshing lifestyle." Ascera is available to manufacturers in the U.S. and Asia, along with Microban’s support and expertise. Find out more at https://www.microban.com/antimicrobial-solutions/technologies/ascera and get in touch with a representative today! *The Microban® technology used in this product is similar to acids found in nature and is used in multiple consumer product applications Contact Details Audrey Jestin at kdm communications limited, St Neots, UK +44 1480 405333 ideas@kdm-communications.com Company Website https://www.microban.com/

September 13, 2023 10:00 AM Eastern Daylight Time

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Poolbeg Pharma "moving forward rapidly" with POLB001

Poolbeg Pharma PLC

Poolbeg Pharma PLC (AIM:POLB, OTCQB:POLBF) CEO Jeremy Skillington speaks to Thomas Warner from Proactive after announcing the pharma & biotech's interim results for the six months to 30 June 2023. Skillington highlights Poolbeg's "healthy" financial position and attributes it to low operational cash burn and strong financial discipline. Skillington also emphasises cost-effective R&D, citing examples like the LPS challenge study and AI programs that utilise supercomputers for efficiency. They continue to seek non-diluted funding opportunities to support infectious disease programs, following a €2.3 million grant from the Irish government in 2022 for an oral vaccine program. Operational achievements include positive results from a POLB001 LPS human challenge trial, showing potential in treating acute inflammatory conditions and oncology-related issues. The company's collaboration with CytoReason identified valuable drug targets for influenza treatment. Additionally, progress was noted in oral vaccine delivery and clinical trials for an oral GLP-1 agonist. Skillington hinted at new indications for POLB001 in the oncology sector, addressing cytokine release syndrome, a significant market opportunity. Future milestones include RSV dataset validation, oral vaccine encapsulation, and influenza drug target validation. The company remains focused on clinical trial preparations and partnerships with pharmaceutical companies, reflecting a proactive approach to advancing their programs. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

September 13, 2023 08:58 AM Eastern Daylight Time

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BioVie chief social impact officer sees major need for Alzheimer’s support and research

BioVie Inc

BioVie chief social impact officer Sarah Hoit joined Steve Darling from Proactive to talk about the growing need for support for individuals suffering from Alzheimer's Disease and their caregivers, including family members. Hoit emphasized that while research into Alzheimer's treatments and cures is ongoing, it remains a significant challenge. The quest for effective treatments and potential cures is a critical aspect of addressing the Alzheimer's crisis. Hoit addressed how BioVie is helping on the clinical side with a very unique and different approach. Additionally, she shed light on the rising costs associated with Alzheimer's care, which have significant financial implications for both healthcare systems and families. The financial burden of Alzheimer's care often falls on families, and the cost of care can be substantial. Moreover, the interview highlights the importance of brain health throughout one's life, not just in seniors, and the role of epigenetics in controlling around 70% of health outcomes. Hoit also introduced Social Impact Partners, a global brain health initiative, and encourages collaboration between the private sector, nonprofits, and governments to combat the dementia crisis. Overall, the discussion underscored the urgent need for ongoing research, treatment development, and support systems for individuals and families affected by Alzheimer's disease. Contact Details Proactive USA +1 347-449-0879 na-editorial@proactiveinvestors.com

September 12, 2023 02:10 PM Eastern Daylight Time

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Willow Bioscience eyes another use for BioOxi platform with R&D of ursodeoxycholic acid

Willow Biosciences Inc.

Willow Bioscience CEO Dr Chris Savile joined Steve Darling from Proactive to announce some significant developments within the company. Willow Bioscience specializes in the production of ursodeoxycholic acid (UDCA), a vital pharmaceutical ingredient with extensive applications in nutraceutical and pharmaceutical products. UDCA is notably used in the management and treatment of cholestatic liver diseases and gallstone conditions. Moreover, it serves as a crucial intermediate compound for tauroursodeoxycholic acid (TUDCA), an essential active pharmaceutical ingredient in a recently approved combination therapy for the treatment of ALS in Canada and the United States. In partnership with Sandhill One, LLC, Willow has successfully completed research and development on its UDCA program. This collaborative initiative enabled Willow to optimize a proprietary enzyme necessary for UDCA development. Of particular significance is the achievement of selective C-H hydroxylation at an industrial scale, often regarded as a challenging feat in the field of chemistry. Dr Savile's announcement also extended to the financial front. Willow Bioscience is initiating an offering of convertible debenture units in a non-brokered private placement to raise approximately $1.2 million. Notably, insiders, including members of the Board of Directors and senior management, are expected to subscribe to approximately 50% of the total funds raised. This underscores the strong commitment and confidence that the company's leadership has in Willow's vision and future prospects. These developments indicate that Willow Bioscience is making significant strides in its mission to advance pharmaceutical research and contribute to the development of innovative therapies and treatment options. With a focus on expanding its product portfolio and securing essential funding, the company is poised to play a pivotal role in the pharmaceutical and nutraceutical industries. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

September 12, 2023 01:39 PM Eastern Daylight Time

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Cannabis As Effective As Opioids for Treating Neuropathy Pain, Say Respondents to New Survey

NuggMD

Cannabis may be as effective at treating symptoms of neuropathy as are addictive drugs such as opioids, according to the results of a new survey from NuggMD, the largest telehealth platform for cannabis. Furthermore, according to respondent data, the potency of the cannabis used to treat the condition is more predictive of pain relief than any other variable, including frequency of consumption. This data calls into question the validity of previous research on this subject that used low-potency cannabis. Conducted earlier this year, the survey polled 9,700 cannabis users who have neuropathy and received 603 responses, achieving a confidence level of 95 percent with a 3.87 percent margin of error. The findings were first reported in the cannabis industry outlet Marijuana Moment. Neuropathy is a painful neurological condition that results from nerve damage. The risk of developing neuropathy generally increases with age, and addictive opioids are frequently prescribed to treat its symptoms. However, 10 states list neuropathy as a qualifying medical condition for medicinal cannabis recommendations, and many other states have legal statutes that make cannabis a treatment option for patients who have the condition. “We were not surprised that respondents told us that cannabis is effective for pain relief. What we were surprised by is how much of a factor potency plays in providing that relief among the population that we surveyed,” said Alex Milligan, co-founder and CMO of NuggMD. “Potency may be a more important variable than is commonly understood. We hope that future research further explores the potency factor.” The NuggMD survey included respondents who reported using cannabis with more than 20 percent THC, a potency that is common in both the medical and recreational markets. These respondents reported the greatest levels of relief among survey participants. The positive correlation between potency and pain relief in this survey calls into question the validity of prior studies that used government-grown cannabis, which is generally much lower in potency. Until 2021, government researchers were hamstrung by federal regulations that allowed them to use cannabis from just one source in their research. By contrast, there are many thousands of cannabis varieties available in legal markets, many of which may produce unique clinical effects because of varying chemical profiles, terpenes, and potencies. The NuggMD survey is not a peer-reviewed study and it contains selection bias. It does not provide causal evidence of cannabis being effective in the treatment of neuropathic pain. Further research into this subject by medical professionals is necessary. NuggMD’s report on the survey was written by Alexandra Arnett, MS, fact-checked by NuggMD legal and policy researcher Deb Tharp, and medically reviewed by Dr. Brian Kessler. The company can provide the full data set of its work to journalists and third-party researchers upon request. About NuggMD NuggMD is the nation's largest medical marijuana technology platform, serving patients in California, Connecticut, Georgia, Illinois, Iowa, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Jersey, New York, Ohio, Oklahoma, Pennsylvania, Texas, Vermont, Virginia, Washington, and West Virginia. They've connected over 1,000,000 patients face-to-face with their new medical marijuana doctors via their state-of-the-art telemedicine platform. They believe every human being has the right to explore the benefits of medical cannabis and are fully committed to helping each patient explore every option in their journey to wellness. For further information, visit NuggMD.com. Contact Details Andrew Graham +1 646-385-0189 andrew.g@getnugg.com Company Website http://www.nuggmd.com

September 12, 2023 12:23 PM Eastern Daylight Time

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