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Addex Therapeutics focused on securing new partnerships to fund promising treatments

Addex Therapeutics Ltd

Addex Therapeutics co-founder and CEO Tim Dyer speaks to Thomas Warner from Proactive about the work that the central nervous system-focused clinical-stage pharmaceutical company has been doing in the promising area of allosteric modulation. He explains that company is currently collaborating with Johnson & Johnson on a phase two study for epilepsy, with results expected in Q2 of the following year. Additionally, Addex is developing treatments for chronic cough, schizophrenia, and cognition, with the latter receiving a grant from the European Union. Dyer explains that the company's unique approach to allosteric modulation offers a competitive edge in drug discovery, setting them apart from competitors. Their long-term strategy revolves around advancing their programs and securing partnerships to ensure steady cash inflows, especially given the challenging capital market environment. With seven programs in the pipeline and two already partnered, Addex is poised for significant growth in the coming years. Dyer says that "at the moment we continue to move the programs forward... we're very focused today on securing cash inflows to keep the business going through partnerships." Contact Details Proactive United States Proactive United States +1 347-449-0879 action@proactiveinvestors.com

October 05, 2023 11:20 AM Eastern Daylight Time

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Shield Therapeutics' pricing will be "key metric" - Proactive Research Analyst

Shield Therapeutics PLC

Proactive Research Analyst Robin Davison speaks to Thomas Warner after publishing a new research note on iron defiency-focused commercial-stage specialty pharmaceutical company Shield Therapeutics. Davison gives an overview of what readers can expect from the note, highlighting Shield's recent half-year results and accompanying financing transactions. The company's burgeoning relationship with commercial partner Viatris is a key focus. While the product's trajectory is promising, Davison explains that Shield has been grappling with the challenge of drug reimbursements in the US, leading to the incurring of some costs. However, plans are underway to assist doctors in navigating this system, with a view to securing a higher average drug price. Davison suggests that Shield's ability to increase that average price will be a "key metric going forward." He concludes by saying that "the trajectory is going extremely well, [they' really just want to get the pricing issue sorted now and it should be a great story." Davison's research note is available on the Proactive website as is a interview with Shield Therapeutics' CEO Greg Madison. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 05, 2023 04:00 AM Eastern Daylight Time

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Northern Leaf "on the road in terms of sales" ahead of London listing

Northern Leaf

Northern Leaf CEO Don Perrott speaks to Thomas Warner from Proactive London about the Jersey-based medical cannabis company's progress towards a potential AIM-listing later this year. Perrott gives an overview of the business and its achievements since being incorporated in 2019, highlighting its 100,000 square-foot glasshouse facility that produces six to eight tonnes of medical cannabis annually and its its EU Good Manufacturing Practice (GMP) and Good Clinical Practice (GCP certifications). He discusses the benefits the advantages of operating in Jersey, which include a supportive government and competitive electricity costs. Northern Leaf is gearing up for a listing on AIM in the fourth quarter, with substantial progress already made in its IPO preparations. Perrott emphasises the commitment to producing high-quality, consistent medical cannabis and says the company is "on the road in terms of sales" with a shipment already on its way to Australia and deliveries to the UK and Germany scheduled. Perrott also expresses confidence in Northern Leaf's ability to navigate an often complex regulatory environment, saying that the company is "on top of regulations" and embracing the opportunities being created. Contact Details Proactive UK Ltd Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 05, 2023 03:57 AM Eastern Daylight Time

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Shield Therapeutics "couldn't be more pleased" with Viatris collaboration

Shield Therapeutics PLC

Shield Therapeutics PLC (AIM:STX, OTCQX:SHIEF) CEO Greg Madison speaks to Thomas Warner after a busy week for the commercial stage pharmaceutical company, which included the release of its interim results and the announcement of a major fundraise. He highlights the success of the fundraise, which comprised US$20 million from a new senior debt facility as well as an equity fundraise (split between a share placing, a subscription and an offering to retail investors) that brought in an additional US$6 million. He explains that the new funding is going to be put to use in "paying off an existing loan, increasing our working capital needs and then certainly some commercial investments to accelerate the curve that we're seeing here." The curve he describes is the marked increase in demand for Shield's Accrufer product, which is a stable, non-salt based oral therapy for adults with iron deficiency that is designed to avoid some of the unwanted side-effects of conventional iron tablets. He says he "can't speak highly enough about the dedication and passion of [his] team at Shield, but also about our partner Viatris... we made an excellent choice... we couldn't be more pleased with the partnership and the collaboration we're seeing." Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 05, 2023 03:00 AM Eastern Daylight Time

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Nuformix to fund its unlicensed programs with NXP001 windfall

Nuformix PLC

Nuformix PLC (LSE:NFX) executive director Dr Dan Gooding speaks to Proactive after the pharmaceutical development company announced it is to receive new immediate and near-term milestone payments as part of an update to its NXP001 exclusive licensing agreement with Oxilio Ltd. Dr. Gooding explains that Oxilio has now purchased patents from Nuformix that it had previously been licencing, resulting in significant near-term payments to Nuformix. This financial boost will aid Nuformix in advancing their unlicensed programs, specifically NXP002 and NXP004. Despite the patent sale, Nuformix retains future value from NXP001 through development milestones and royalties. Dr. Gooding also highlights Nuformix's work with NXP002 on lung fibrosis, a severe disease with limited treatment options. He explains that Nuformix's approach of repurposing existing drugs means a reduction in research time and costs. NXP002 is a modified version of a drug initially approved in Japan for asthma and skin scarring treatment. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 05, 2023 03:00 AM Eastern Daylight Time

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NMTC Coalition, 700 Organizations Urge White House, Congressional Leadership to Make NMTC Program Permanent

New Markets Tax Credit Coalition

Today, the New Markets Tax Credit (NMTC) Coalition, a national membership organization of Community Development Entities (CDEs) and investors organized to advocate on behalf of the NMTC, released a letter signed by nearly 700 community development stakeholders to President Biden and Members of Congress in support of enactment of a permanent extension to the NMTC in end of the year tax legislation. Despite its efficacy and importance for businesses and community development projects, the NMTC program expires in 2025. Signatories on the letter include 275 community development organizations; 76 housing organizations; 140 nonprofits, shelters, schools, healthcare facilities, and community service providers; 166 businesses and community development-focused investors; and 31 state and national community development trade associations. “We strongly support making the NMTC permanent,” said Aisha Benson, President of the NMTC Coalition and President and CEO of Nonprofit Finance Fund. “We’ve seen the enormous impact NMTCs can have in strengthening communities across the country, as well as in our own work in Arkansas and Ohio. We are committed to ensuring no community is left behind and preserving one of the federal government’s most successful community development programs.” During this Congress, both the Senate and House introduced bills (S. 234 and H.R. 2539) with bipartisan support to make the NMTC extension permanent. Establishing permanence will provide certainty in delivering resources to low-income and marginalized communities, creating jobs, increasing economic opportunity, and improving lives at a time when underserved communities face significant challenges. Throughout its 20-year history, the NMTC has delivered more than $125 billion to rural and urban communities outside the economic mainstream, which has led to financing to more than 8,000 businesses and projects and over one million jobs. Establishing the NMTC as a permanent part of the tax code will provide certainty and further promote getting patient, flexible capital to low-income and marginalized communities, creating jobs, increasing economic opportunity, and improving lives at a time when the economic frailty of our underserved communities has never been more apparent. Established in 2000 in the Community Renewal Tax Relief Act (P.L.106-554), the New Markets Tax Credit is a bipartisan effort to stimulate investment and economic growth in low-income urban neighborhoods and rural communities. “With the continuing impacts from COVID-19, and the general economic uncertainty felt across the country, the New Markets Tax Credit is absolutely vital for many of America’s urban neighborhoods and rural communities and will provide billions of dollars for high-impact, community revitalization projects,” said Bob Rapoza, spokesperson for the NMTC Coalition. “Over the years, the credit has been instrumental in financing plant and equipment for small manufacturing businesses and patient, flexible capital to other small businesses, hospitals, healthcare centers, homeless shelters and other transformative projects that improve communities, create jobs and economic opportunity. A permanent extension of NMTC will provide more certainty to private sector investors, which will result in better pricing and more subsidy to hard-to-finance, essential projects.” For examples of how the NMTC is making an impact in each state, see the NMTC Coalition’s website, where you can find over 2,500 NMTC success stories organized by state and congressional district. About New Markets Tax Credit Program -- The New Markets Tax Credit (NMTC) was enacted in 2000 to stimulate private investment and economic growth in low-income urban neighborhoods and rural communities lacking the patient capital to support and grow businesses, create jobs, and sustain healthy local economies. Since its inception, the NMTC has generated more than one million jobs. Today due to NMTC, more than $120 billion is hard at work in underserved communities in all 50 states, the District of Columbia, Guam and Puerto Rico. For examples of how the NMTC impacts each state, see the NMTC Coalition’s project database and state fact sheets. For more information, visit www.NMTCCoalition.org. Contact Details Greg Wilson +1 571-239-7474 gregwilsonpr@gmail.com Company Website https://nmtccoalition.org/

October 04, 2023 12:27 PM Eastern Daylight Time

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NetScientific "well positioned for growth" when venture capital market turns

NetScientific PLC

NetScientific PLC (AIM:NSCI) CEO Dr Ilian Iliev speaks to Thomas Warner from Proactive after the investment and commercialisation group published its interim results for the six months ended 30 June 2023. Dr Iliev provides some context for the half-year results, saying that the company has been working hard and focusing on executing its strategy in what has been a "difficult period" for venture capital. He goes on to give an overview of the half-year results, saying that he's "happy to report strong progress in the first half of the year" and highlighting the realisation of "roughly £800,000 in profitable partial exists from the portfolio" during the period. He addresses how the challenges affecting the wider venture capital sector are playing out at NetScientific and expresses confidence in what the company calls its "evergreen" strategy, saying that its "well positioned for growth when inevitably the cycle turns around... we are not venture capital tourists - this is what we do on a daily basis and we are positioning ourselves for the inevitable turnaround." Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 04, 2023 04:17 AM Eastern Daylight Time

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Unwiring.org Takes Bold Steps to Reform Social Media For a Healthier, More Connected Future

Unwiring

Unwiring officially launches to empower individuals in the fight against social media's negative impacts and unethical practices. The organization is led by Saahil Mishra and a diverse team of passionate teens who’ve developed several initiatives to catalyze positive change within social media. “I worry about the impact of social media on my generation. A surge in social isolation, mental health issues, disinformation, and political polarization has challenged our connection on both an interpersonal and societal level,” said Saahil Mishra, founder and social media activist. Mishra also serves as a research assistant at Stanford Social Media Lab and writer for the Poynter Institute’s Media Wise. Earlier this year, Mishra participated in his first TEDx Talk event in San Francisco. Unwiring is educating and empowering young people to drive real, representative change within social media. The team curates timely educational resources including a series of self-produced online videos, curriculum on social media’s inner workings and impacts, and editorial pieces centered around the youth perspective on social media’s harms and possible solutions. Unwiring also is hosting a ReDesign challenge for youth to pose ideas for social media reformation this fall and a youth summit in 2024. United States Surgeon General Dr. Vivek Murthy issued a call for urgent action by policymakers, technology companies, researchers, families, and young people alike to gain a better understanding of the full impact of social media use. Recent research shows that adolescents who spent more than three hours daily on social media faced double the risk of experiencing poor mental health outcomes, such as symptoms of depression and anxiety. “When we advocate for internal platform changes, business model regulations, major culture and paradigm shifts, we can together build a healthier more connected future,” adds Mishra. “We invite teens to join us in this important movement by sharing their stories with us.” Visit unwiring.org and engage on Instagram, YouTube, TikTok, X formerly known as Twitter: @unwiring_org. Contact Details Unwiring Anne Shanahan, Community Relations Liaison +1 562-810-3016 ashanahan@unwiring.org

October 03, 2023 08:05 AM Pacific Daylight Time

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GS National Insurance Partners with AmeriLife to Propel Growth & Expansion

AmeriLife

AmeriLife Group, LLC (“AmeriLife”), a national leader in developing, marketing, and distributing life and health insurance, annuities, and retirement planning solutions, announced today that it has partnered with Pittsburgh-based GS National Insurance (“GS National”), a wholesale distributor of health insurance products for independent brokers and agencies. Per the agreement, terms of the deal were not disclosed. “Over the last decade, GS National has experienced significant growth, and we’re excited to take our business to another level,” said Brian Breisinger, founder, president and CEO of GS National Insurance. “We have always strived to break through the complexities of the insurance business with simplicity, transparency and recognition at the heart of our approach. Together with AmeriLife, we’ll be able to support even more independent brokers and agencies at scale than ever before.” Founded in 2007 as independent health insurance agency, Gateway Strategies, the firm grew quickly over the next three years as it recognized the need for more tailored support of brokerage companies in a rapidly evolving Medicare marketplace. In 2010, it shifted its focus to wholesale distribution under the name GS National Insurance, working with a growing number of local and regional health insurance carriers and expanding its footprint to seven states across the eastern United States. Now, together with AmeriLife’s best-in-class tools, resources, and holistic product offerings, GS National is well-positioned for accelerated growth and long-term success. “I’m thrilled to welcome Brian and GS National to AmeriLife,” said Scotty Elliott, Chief Distribution Officer for AmeriLife Health. “The team’s focus on cultivating strong relationships with carriers and providing exceptional value for their agents has been key to their rapid growth. We look forward to supporting their ambitions for years to come.” “GS National has proven to be not only a successful wholesale distributor, but also an innovator in our space,” added Tim Calvert, Chief Operating Officer for AmeriLife. “We’re excited to add Brian’s and the team’s expertise and industry leadership to our growing network of affiliates. ### About GS National Insurance Founded in 2007, GS National Insurance is a national wholesale distributor of insurance products for independent brokers built on the belief that simplicity, transparency and recognition are the cornerstones for success in the insurance industry. For more information, visit GSNational.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as a leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and 120 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. Contact Details Media Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Partnership Inquiries Patrick Nichols +1 727-726-0726 pnichols@amerilife.com Company Website https://amerilife.com/

October 03, 2023 09:30 AM Eastern Daylight Time

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