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MGC Pharmaceuticals receives permission to import psilocybin mushrooms into Europe

MGC Pharmaceuticals Ltd

MGC Pharmaceuticals Ltd (LSE:MXC, OTC:MGCLF, ASX:MXC) CEO and managing director Roby Zomer speaks to Thomas Warner from Proactive after the Europe-based plant-inspired medicine company announced it has secured permission to import 200g of psilocybin mushrooms into Slovenia for analysis. The news is significant because its the first time the company has been granted permission to import the naturally-occurring psychedelic compound into the country. Zomer explains that MGC Pharma has been contracted by a pharmaceutical company based in Southern Africa to import psilocybin mushrooms grown in the region to MGC's facility in Slovenia. As a certified pharmaceutical company in Europe, MGC Pharma will provide the necessary support and infrastructure to help their partner gather essential data for obtaining marketing approval for the product in other countries. Despite this new collaboration, Zoma emphasized that MGC Pharma's primary focus remains on their existing treatments for refractory epilepsy and immune modulation. However, they recognise the potential of psilocybin as an innovative medicine for the future, particularly in palliative care and post-traumatic treatments. MGC Pharma aims to stay at the forefront of this emerging sector and provide services to other companies interested in exploring psilocybin-based therapies. Looking ahead, MGC Pharmaceuticals awaits the arrival of the imported mushrooms in Slovenia with a view to commencing the testing and development processes. Additionally, updates are expected on their cannabinoid treatments in the UK, as well as their relations and expansion in America. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

August 01, 2023 04:14 AM Eastern Daylight Time

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Proactive Research Analyst says Shield Therapeutics' commercialisation drive "going well"

Shield Therapeutics PLC

Proactive Research Analyst Robin Davison speaks to Thomas Warner after publishing a new research note on Shield Therapeutics PLC, following the release of new prescription data from the commercial-stage specialty pharmaceutical company for its iron deficiency treatment Accrufer/Feraccru. The key highlight from the analysis is the significant increase of 50% in prescriptions during the second quarter, specifically for Accrufer. The number of doctors prescribing the drug for the first time has also shown a positive trend, with a considerable proportion of those doctors continuing to prescribe it in the following quarter. Davison says that the company's efforts in commercialising the product are "going well", with more benefit expected to come following the expansion of their sales force in June. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

August 01, 2023 03:45 AM Eastern Daylight Time

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Syntekabio and Metaclipse sign MOU for Joint Research on Personalized Immunotherapy for Cancer

Syntekabio, Inc.

Syntekabio (KOSDAQ: 226330), an Artificial Intelligence (AI) based drug development company, announced that it has signed a MOU with Metaclipse Therapeutics, an Atlanata, GA USA based biotechnology company developing immunotherapies for cancer and vaccines for infectious disease, for joint research on development of a personalized immunotherapy for cancer. Through this MOU, Syntekabio plans to support Metaclipse in conducting research on neoantigen identification for its Membrex TM personalized cancer vaccine platform. Metaclipse’s Membrex™ vaccine is a personalized immunotherapy for solid tumors comprising a patient tumor antigen source combined with the company’s proprietary membrane-linked biological adjuvants. The company has received approval from US FDA to proceed with a phase 1 clinical trial and will work with Syntekabio to leverage its proprietary NEO-ARS® platform to identify neoantigen candidates that generate patient-specific anti-tumor immune responses. Michael Coleman, CEO of Metaclipse, said, “The TMV-based cancer vaccine has the advantage of presenting a broad array of potential neoantigens derived from the patient’s tumor, thereby providing a personalized immunotherapy for cancer. With this MOU agreement, we plan to identify neoantigen candidates, which play a critical role in activating the patient’s immune system and provide the potential for tailoring patient-specific booster doses and developing off-the-shelf Membrex TM therapies with broad application.” Jongsun Jung, CEO of Syntekabio, said, “We are delighted to conduct joint research with Metaclipse, a cancer vaccine specialist in the clinical development stage. We are open to collaboration with companies specializing in the development of cancer vaccines and immunotherapies and will contribute in various ways so that domestic and foreign vaccine manufacturers in clinical stages can achieve positive results.” The Phase 1 clinical trial is to verify the safety and immunological activity of Metaclipse’s tumor membrane vesicle-based vaccine, termed Membrex TM. Syntekabio will contribute to the clinical trial by analyzing genomic data from tumor sample of clinical trial subjects and identifying personalized cancer neoantigens using NEO-ARS®, a neoantigen prediction AI platform. Metaclipse's cancer vaccine incorporates a broad array of tumor antigens in the form of tumor membrane vesicles prepared from the patient's own tumor. This type of vaccine has the advantage of providing a broad array of antigen candidates minimizing selection bias that is present in some other approaches. Through the joint research, the two companies expect to be able to identify the most immunologically relevant antigens by utilizing Syntekabio's NEO-ARS® platform. After this agreement, the two companies plan to comprehensively analyze Syntekabio's neoantigen prediction results and Metaclipse's clinical trial results to evaluate the correlation between the neoantigen profile and treatment response and to conduct joint research to identify potent individual neoantigens that demonstrate high immunogenicity among the many antigens loaded in the Membrex TM vaccine. For more information about Syntekabio and its offering, please visit http://www.syntekabio.com/. Contact Details WMSG | Syntekabio USA +1 201-402-1400 wgroup@wmedical.org Company Website http://www.syntekabio.com/

July 31, 2023 02:58 PM Eastern Daylight Time

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News Release

Neural Therapeutics gets go-ahead from Peruvian Government to work with San Pedro Cactus

Neural Therapeutics Inc.

Neural Therapeutics CEO Ian Campbell joined Steve Darling from Proactive to share the news that after 11 months of rigorous review, the company has received permission from Peru's Ministry of Agriculture to access genetic resources and their derivatives for the evaluation of the mescaline-containing cactus species of the Echinopsis genus, commonly known as San Pedro or Huachuma, for possible medicinal purposes. The company's plan is to develop intellectual property that will pave the way for drug development using mescaline. Mescaline is a chemical compound classified as a psychedelic and has shown potential medicinal and therapeutic applications. It is derived from the Peyote and San Pedro cacti. Neural Therapeutics is committed to sustainable practices throughout its exploration and development of mescaline-containing cacti. This includes replanting, donating samples for genetic preservation, and publishing biomarker data to aid in the preservation of wild stands of these cacti species. The access to genetic resources and derivatives of the San Pedro cactus will enable Neural Therapeutics to further explore the potential medicinal benefits of mescaline. The company's efforts could lead to the development of novel therapeutic options and potentially expand treatment options for various medical conditions. As the research progresses, Neural Therapeutics aims to ensure responsible and sustainable practices to safeguard the preservation of these valuable plant species. This approach aligns with the growing interest in harnessing the potential of natural compounds for therapeutic purposes while respecting the environment and preserving biodiversity. Contact Details Proactive Investors +1 604-688-8158 na-editorial@proactiveinvestors.com

July 31, 2023 11:29 AM Eastern Daylight Time

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Osteopore "chasing the holy grail of tissue regeneration”

Osteopore Ltd

Osteopore Ltd (ASX:OSX) Chairman Mark Leong speaks to Thomas Warner from Proactive London about the Australian-Singaporean medical technology company's pursuit of what he calls the "holy grail of tissue regeneration." Leong explains that aiming to commercialise products designed to enable natural bone healing across multiple therapeutic areas, including both hard and soft tissue. Initially focused on bone regeneration, Osteopore has received major regulatory approvals for their implants. However, their technology also holds promise for soft tissue regeneration, including shoulder rotator cuff tendon repair and cartilage regeneration. Looking ahead, the company aims to enter the "huge" Chinese market and is actively researching ways to accelerate tissue regeneration, potentially reducing healing time significantly. He says "In the next half a year or so you'll see us breaking some new ground into entering the Chinese market... and on the technology front we will be putting more effort into developing the soft tissue part because that's a whole new area of therapeutic treatment... we are chasing the holy grail of tissue regeneration which is to speed up tissue regeneration." Contact Details Proactive Australia Pty Ltd Proactive Australia Pty Ltd +61 431 597 771 action.australia@proactiveinvestors.com

July 27, 2023 06:00 PM Eastern Daylight Time

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4GLOBAL "very pleased" with final results and looking to the future

4GLOBAL PLC

4GLOBAL PLC (AIM:4GBL) CEO Eloy Mazon speaks to Thomas Warner from Proactive London following the release of audited final results for the year ended 31 March 2023. Mazon gives his highlights from the news release, saying that "all in all we are very pleased with the year", which was the company's first as a listed entity. Group revenues for the year ending 31 March 2023, grew by 53% to £5.6mln, with basic earnings per share closing at 2.4p compared to losses of 7.1p in 2022. Mazon says that strong demand from international markets played a significant role in the results and aligning with the company's growth strategy. Looking ahead, Mazon says 4GLOBAL PLC is focusing on capitalising on the strong demand, particularly in the North American market, where they have established key relationships and commercial partnerships. He explains that commercial partnerships, like the recent one with Jonas Fitness in the US, provide a valuable route to market and complement their product offerings and client onboarding capabilities. As the market shifts towards valuing data and insights, 4GLOBAL PLC aims to leverage its extensive database and technology for cleansing and transforming data into actionable insights. They also have plans to explore AI integration with a view to providing more valuable insights to their customers. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:43 AM Eastern Daylight Time

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Oxford Cannabinoid Technologies "officially on the way" after first dosing

Oxford Cannabinoid Technologies Holdings PLC

Oxford Cannabinoid Technologies Holdings PLC (LSE:OCTP, OTCQB:OCTHF) Clarissa Sowemimo-Coker speaks to Thomas Warner from Proactive London after announcing that the company has commenced its phase I clinical trial for the lead drug candidate, OCT461201, marking the administration of the first human dose. Researchers will assess the pain relief treatment's safety, tolerability, and pharmacokinetic profile (how it interacts with the body). Sowemimo-Coker says its "so important to have that significant milestone of finally getting that first dose into a healthy volunteer, so we can officially say we're on the way and looking forward to getting those results over time." The trial holds promise for patients suffering from chemotherapy-induced peripheral neuropathy (CIPN), a condition affecting 60% of chemotherapy recipients, causing severe pain and sensitivity in extremities. Sowemimo-Coker also highlights the recent addition to the team of Dr. Farquhar Smith, who runs the only CIPN clinic in the UK at the Royal Marsden. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:39 AM Eastern Daylight Time

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Oxford Cannabinoid Technologies first dosing a "major achievement" - Proactive Research Analyst

Oxford Cannabinoid Technologies Holdings PLC

Proactive Research Analyst Daniel Appiah speaks to Thomas Warner at the London Studio after publishing a new research note on Oxford Cannabinoid Technology Holdings PLC. The pharmaceutical group announced on 27 July that it has commenced its phase I clinical trial for lead drug candidate, OCT461201, marking the administration of the first human dose. Appiah describes the news as a "major achievement" for Oxford Cannabinoid Technologies, highlighting its transformation from a development company into being a clinical company He also gives an overview of other recent news from the business. For more details, read Daniel's full report by clicking the link provided. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

July 27, 2023 10:38 AM Eastern Daylight Time

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PathAI Launches its AI-Powered PathExplore Data Access Program for Academic Researchers

PathAI

PathAI, a global leader in AI-powered pathology, today announced it has applied its PathExplore panel of human interpretable features (HIFs) on publicly available samples from The Cancer Genome Atlas (TCGA), a comprehensive resource of oncology data containing genomic and outcomes data, along with associated H&E whole-slide images (WSIs). PathAI will make the HIFs from eight TCGA cancer types available for free as a data access program for academic researchers to perform independent research to support their own investigations. Earlier this year, PathAI launched PathExplore, an AI-powered panel of HIFs offering unprecedented resolution of the tumor microenvironment (TME) from digitized H&E slides. Powered by artificial intelligence, PathExplore spatially characterizes the TME with single-cell resolution, giving researchers the ability to unlock insights on patient response, drug pathways, and potential novel biomarkers. The ability to characterize and quantify histopathological features of the TME will enable new avenues of disease research, and may lead to promising new therapies. With this PathExplore HIF research data set, oncology researchers can analyze tissue compositions, cell populations, and how their quantities and spatial relationships correlate with molecular signatures, treatment response or prognostic outcomes. This data set is the first of its kind: no other widely available quantitative, structured data set based on histopathology exists. The features are standardized across indications, so researchers can glean new insights into the common or distinct TME characteristics of each tumor type or patient subset. Adding structured and standardized pathology data to TCGA enables a new set of multi-model investigations for researchers to pursue, all while lowering the barrier to integrating pathology image data into biomedical research that previously had been restricted to labs that had access to manual pathology analysis. “The TME has been a challenge to fully investigate due to the sheer amount of spatially distributed information contained within it,” said Mike Montalto, PathAI’s chief scientific officer. “Pathologists can assess the specimens and try to estimate how certain cell or tissue growth patterns are present in each patient, but they cannot exhaustively enumerate each and every relevant cell type under the microscope. That is what our PathExplore products provide - they not only accurately identify where each cell is located, but they provide structured and standardized feature tables that can enable next generation pathology research to be performed.” To learn more about PathAI’s PathExplore HIF research data set and apply for access, please reach out to pathexplore.hifs@pathai.com. If approved, there is no cost to academic researchers to access and use these data sets. PathExplore HIFs are for research use only and not for use in diagnostic procedures. Biopharma industry partners interested in purchasing a license to access PathExplore TCGA HIFs may reach out to bd@pathai.com for more information. PathAI is the only AI-focused technology company to provide comprehensive precision pathology solutions from wet lab services to algorithm deployment for clinical trials and diagnostic use. Rigorously trained and validated with data from more than 15 million annotations, its AI-powered models can be leveraged to optimize the analysis of patient samples to improve efficiency and accuracy of pathology interpretation, as well as to better gauge therapeutic efficacy and accelerate drug development for complex diseases. PathAI, which is headquartered in Boston, MA, and operates a CAP/CLIA-certified laboratory in Memphis, TN, is proud to have a team of 600+ innovative thinkers from around the globe. For more information, please visit www.pathai.com. Contact Details SVM Public Relations and Marketing Communications Maggie Naples +1 401-490-9700 pathai@svmpr.com Company Website https://www.pathai.com/

July 27, 2023 10:00 AM Eastern Daylight Time

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