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Lisata Therapeutics advances lead asset LSTA1 for treatment of advanced solid tumors

Lisata Therapeutics Inc

Lisata Therapeutics CEO David J. Mazzo discusses the oncology company's focus and recent advancements in an interview with Proactive's Stephen Gunnion. Lisata Therapeutics, established 18 months ago through the acquisition of Cend Therapeutics by Caladrius Biosciences, is dedicated to developing technologies aimed at treating solid tumour cancers. The company's primary product, certepetide (LSTA1) is a nine amino acid cyclic peptide designed to target and penetrate tumours. It is used in combination with chemotherapy and other cancer treatments. Currently, the most advanced programme targets metastatic pancreatic ductal adenocarcinoma, with phase 2B results expected later this year. Lisata has also received several orphan drug designations, including for pancreatic cancer, glioblastoma, and osteosarcoma. Additionally, it has a rare paediatric disease designation for osteosarcoma in the US. Mazzo highlighted discussions with regulatory authorities in Australia, the EMA, and the FDA about potential accelerated approval based on upcoming trial results. He expressed optimism about commercializing List-1 as early as 2026 under ideal conditions. Investors can look forward to various clinical and data milestones in the next 12 to 18 months, including potential business development activities. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

April 23, 2024 10:48 AM Eastern Daylight Time

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Made in the USA: Ultrahuman plants flag in US with manufacturing facility UltraFactory to make first wearable rings in the country

Ultrahuman

With smart ring market leadership within its sights, Ultrahuman has today announced plans to open a manufacturing facility poised to accelerate its production capacity. The UltraFactory will be located in Indiana. It opens within the next six months and will be the launchpad for Ultrahuman’s next phase of growth. The UltraFactory will offer an end-to-end production capability and is based on the company’s first operational model of such a facility in India. This development comes hot on the heels of a $35 million fresh investment in the company (series B funding round) and reaffirms Ultrahuman’s ambition to become the market leader in the smart ring space in the next 12 to 15 months. The company has already seen phenomenal growth over the past year, becoming the second-largest player in the smart ring market while maintaining profitability. The opening of the new UltraFactory, will add a production capacity of 200,000 smart rings and present an additional $100m revenue opportunity annually. This is a push towards establishing smart ring market leadership in the US. Ultrahuman’s ability to make significant long-term manufacturing investments, supported by its profitability, is unique in the smart rings market. As a result, UltraFactory’s cutting-edge end-to-end production capabilities will enable the company to fully capitalize on what the company sees as its biggest competitive advantage: fast product development and iteration, and speed of execution in rolling out to global markets. With the US market growing in importance for Ultrahuman in recent months, the move will help the company lower costs in shipping and logistics, while aiding the US government in its push to strengthen domestic manufacturing rather than manufacturing in offshore locations, like China. This brings an expected hiring boom of 150 new Ultrahuman employees in the US over the next 12 months split between engineering and research (30%) and commercial operations (70%). Mohit Kumar, Founder and CEO of Ultrahuman commented: “US is an interesting market for us given it has always been huge in terms of demand for the product but we’re also seeing tremendous value from a manufacturing and research perspective. UltraFactory US would enable manufacturing for health tracking smart ring devices and give us the ability to do necessary research to evolve the form factor further.” Ultrahuman has seen phenomenal growth over the past 12 months, becoming the second-largest player in the smart ring market while maintaining profitability. "Our vision of being the top player in terms of both active devices and geographic presence is within reach, thanks to our rapid expansion and the love we've received from our users," added Mohit Kumar. UltraFactory will help Ultrahuman support its recent retail expansion into over 150 outlets worldwide, spanning iconic locations like London’s Selfridges on Oxford Street, Changi Airport in Singapore, and the Virgin megastore in Dubai. In addition to their smart ring called Ring AIR, the Ultrahuman product suite includes a continuous glucose monitoring wearable called M1 Live, a home health device called Ultrahuman Home and a preventive blood testing product called Blood Vision. Their platform integrates glucose, sleep, movement, blood markers, and HRV, offering a comprehensive approach to health monitoring. "Our growth is a testament to the user love for our products, highlighted by industry-leading NPS and engagement metrics since the launch of our latest model, the Ring AIR. Our relentless focus on improving user experience through continuous firmware and software updates is what sets us apart," Mohit Kumar emphasized. "Shipping a new firmware version every 2 weeks and weekly app improvements reflect our commitment to excellence and our speed of execution, our biggest competitive advantage. We’ve also iterated on hardware at the speed of software by designing novel devices like Ultrahuman Home, a home health monitor.” Looking ahead, Ultrahuman is on track to surpass $100 million in annualized revenue run rate (ARR) by the end of 2024, a milestone that will be achieved profitably. "Our ability to make long-term manufacturing investments, supported by our profitability, is unique in the smart ring market," Mohit Kumar noted. Ultrahuman's dedication to scientific validation and innovation is further evidenced by the completion of a clinical trial involving 105 participants, aimed at validating the ‘Metabolic Score’ generated on the Ultrahuman platform. "Our long-term investment in R&D and intellectual property is a cornerstone of our strategy, ensuring that our products not only meet but exceed the highest standards of efficacy and reliability," Mohit Kumar concluded. About Ultrahuman Ultrahuman is the world's most advanced metabolic fitness platform. Ultrahuman’s products include the Ultrahuman M1(continuous glucose monitoring sensor), the Ultrahuman Ring and Blood Vision, a preventive blood testing platform with the pioneering UltraTrace™ technology. By collating different biomarkers, Ultrahuman is helping people improve their energy levels and lifestyle, track their workout, sleep and recovery, and avoid metabolic disorders. For more information and updates on Ultrahuman, please visit ultrahuman.com or follow us on Facebook, Instagram, Twitter, LinkedIn, and YouTube. Contact Details Ultrahuman Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Ultrahuman Hisham Syed hisham@ultrahuman.com Company Website https://www.ultrahuman.com/

April 23, 2024 10:15 AM Eastern Daylight Time

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ANGLE achieves breakthrough with EU patent for CellKeep technology, with the US to follow

ANGLE PLC

ANGLE PLC chief executive Andrew Newland discussed significant advancements in the company's technology, including a European patent for the CellKeep slide, with US intellectual property protection from the US set to follow soon. Newland told Proactive's Stephen Gunnion that CellKeep significantly improves the deposition of cancer cells on microscope slides, a common issue in medical laboratories. This method notably reduces cell loss during the transfer process by over 70%, addressing a longstanding problem in the industry. The innovation involves a special funnel attached to the slide, allowing gentle centrifugation and liquid removal while maintaining cell integrity, thereby increasing the effectiveness of subsequent analyses. Additionally, Newland highlighted the development of optimized antibodies for cell phenotyping, which are integrated into ANGLE's Parsortix system. This integration is packaged as the Portrait Plus CTC Staining Kit, simplifying the process for less experienced labs and extending market reach. The kit includes a mix of dehydrated antibodies, designed for ease of use and long shelf life, enhancing the diagnostic process's reliability and efficiency. Commercially, ANGLE has introduced these innovations in a comprehensive kit format, priced at £3,000 for ten samples, significantly enhancing the company’s value offering. Newland also touched on ANGLE’s positive business trajectory, mentioning a breakthrough in DNA profiling and a substantial contract with a major pharmaceutical company, which could potentially yield significant revenues through the development of companion diagnostics. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 23, 2024 09:17 AM Eastern Daylight Time

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World-Renowned Neurologist and Bestselling Author Joins Forum Health’s Annual Integrative Medicine Summit

Forum Health

Forum Health, LLC, leading nationwide network of integrative and functional medicine providers, is thrilled to announce Dr. Dale Bredesen, a trailblazing neuroscientist and pioneer in Alzheimer's disease research, as the keynote speaker at the Forum Health Summit: Emerging Therapies in Integrative Medicine. Register for the Forum Health Summit here. With a career spanning over four decades, Dr. Bredesen has made groundbreaking contributions to neurological research, cognitive decline treatment, and Alzheimer's disease with his renowned Bredesen Protocol - the only Alzheimer’s treatment where the most patients have stabilized or improved. Dale Bredesen, MD: “I’m honored to be the keynote speaker at Forum Health’s annual summit. They are setting the stage to discuss the latest advancements in integrative medicine, bringing together the nation’s top providers, and providing me with the opportunity to share insights and collaborate with my colleagues to drive innovation and progress." Dr. Bredesen's presentation will delve into the latest advancements in Alzheimer's research and shed light on the importance of personalized medicine in combating cognitive decline. Attendees will receive invaluable insights into treatment modalities and preventative measures to preserve brain health. Phil Hagerman, Forum Health CEO: "We’re thrilled to have Dr. Bredesen join us this year. His unparalleled expertise and contributions to the medical community have been instrumental in advancing new treatment approaches to transform the landscape of Alzheimer's disease." The Forum Health Summit is a one-day conference that brings together the top thought leaders in integrative and functional medicine. Attendees receive the latest on emerging research, cutting-edge diagnosis, and treatment protocols for complex clinical cases from expert leaders in the field. The event will also feature presentations from industry experts including: Sahar Swidan, Pharm.D., BCPS, ABAAHP, FAARFM, FACA - President and CEO of NeuroPharm, and internationally renowned speaker on pain management and HRT Paul Anderson, MD - Recognized educator and clinician in integrative and naturopathic medicine focused on complex infecious, chronic and oncologic illnesses Thomas G. Gulliams, Ph.D. - Former VP of Ortho Molecular and expert in the therapeutic uses of dietary supplements Registration for this event is exclusive to licensed medical professionals, space limited and this event is expected to sell out. Register here. About Forum Health Forum Health, LLC is a nationwide provider of personalized healthcare steeped in the powerful principles of functional and integrative medicine. Our providers take a root-cause approach to care exploring lifestyle, environment, and genetics to help each patient achieve their ultimate health goals. Members have access to advanced medical treatments and technology, with care plans informed by data analytics and collaborative relationships. For more, visit www.forumhealth.com. Contact Details Forum Health Britt Wittelsberger +1 410-852-0738 bwittelsberger@forumhealth.com Company Website https://forumhealth.com

April 23, 2024 08:50 AM Eastern Daylight Time

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Wolfram and Classiq Integrate Advanced Quantum Software Tools into Mathematica

Classiq Technologies

In a landmark collaboration, Classiq, a leader in quantum computing software, and Wolfram Research, the leading computational software provider, announce a software partnership. This collaboration integrates Classiq’s cutting-edge engine within Wolfram Mathematica, offering a unified solution for the development of quantum and classical algorithms. This integration is targeted at enabling users to leverage the robust capabilities of Wolfram Mathematica for algorithm development and utilize Classiq’s Quantum Model (QMOD) language for quantum algorithm development—all within a single, cohesive environment. This blend of technologies empowers users to define, visualize and optimize quantum algorithms with unprecedented ease and efficiency. Key features of this collaboration are the facilitation of Classiq’s quantum algorithm compilation tailored to specific quantum hardware and ability to intricately develop quantum circuits from a high-level overview down to detailed gate operations. The integration further allows for the execution of these quantum circuits across a diverse array of backends and simulators, directly within the Mathematica notebook. This integration supports researchers by enhancing analytical capabilities, enabling continuous exploration and data assessment. As an example of the potential of this collaboration, the Quantum Differential Equations solver exemplifies how users will be able to tackle complex challenges by defining and executing quantum algorithms like the Harrow–Hassidim–Lloyd (HHL) algorithm and Quantum Singular Value Transformation (QSVT) for matrix inversion, directly from the Mathematica interface. This application highlights the power of combining classical computational methods with quantum processing to solve complex computational problems more efficiently. “The partnership between Classiq Technologies and Wolfram Research reflects a shared commitment to advancing computational excellence,” said Nir Minerbi, CEO of Classiq. “This collaboration not only enhances the toolset available for researchers and developers, we hope to see it pave the way for groundbreaking applications across various scientific and engineering disciplines.” "In the pursuit of applying quantum technologies to address real-world challenges, robust collaboration among industry leaders is paramount. We are delighted to unveil our strategic partnership with Classiq," remarked Mads Bahrami, quantum projects manager at Wolfram. "This partnership underscores the dedication of both entities towards crafting toolsets that empower governments, industries, and academia to tackle complex problems through quantum-classical algorithms." The companies invite those seeking to combine the best of quantum and classical computation to reach out and explore the possibilities this computation integration brings. About Wolfram Founded by Stephen Wolfram in 1987, Wolfram Research is one of the world's most respected computer, web and cloud software companies - as well as a powerhouse of scientific and technical innovation. As a pioneer in computation and computational knowledge, Wolfram has pursued a long-term vision to develop the science, technology and tools to make computation an ever-more-potent force in today's and tomorrow's world. As the creators of Mathematica, Wolfram|Alpha, the Wolfram Language, and Wolfram Quantum Framework, Wolfram is the leader in developing technology and tools that inject sophisticated computation and knowledge into everything. Wolfram's strategy as an organization is to maintain a portfolio of development, from continually strengthening core algorithms and the Wolfram Knowledgebase, to supporting the latest computing and deployment architectures, to developing major new concepts and capabilities - and consistently delivering the results in the form of products, services and experimental initiatives that make breakthrough technology accessible to the broadest possible spectrum of people and organizations. Learn more at: https://wolfr.am/QuantumConsulting https://www.wolfram.com/quantum-computation-framework/ Follow Wolfram on LinkedIn, X, and YouTube. Contact Wolfram quantum team: quantum@wolfram.com Contact Wolfram PR team: outreach@wolfram.com About Classiq Classiq Technologies, the leading quantum software company, provides an all-encompassing platform (IDE, compiler and OS) with a single point of entry into quantum computing, taking you from algorithm design to execution. The high-level descriptive quantum software development environment, tailored to all levels of developer proficiency, automates quantum programming. This ensures that a broad range of talents, including those with backgrounds in AI, ML and linear algebra, can harness quantum computing without requiring deep, specialized knowledge of quantum physics. Classiq democratizes access to quantum computing and equips its users to take full advantage of the quantum computing revolution, including access to a broad range of quantum hardware. Classiq's core technology - algorithmic quantum circuit compilation - is engineered to power the quantum ecosystem of today and the future. Classiq works closely with quantum cloud providers and advanced computation hardware developers providing software for use with quantum computers, HPC and quantum simulators. Backed by investors such as HPE, HSBC, Samsung, Intesa Sanpaolo and NTT, Classiq's world-class team of scientists and engineers has distilled decades of quantum expertise into its groundbreaking quantum engine. Follow Classiq on LinkedIn, X (formerly Twitter) or YouTube, and visit the Slack community and website, www.classiq.io to learn more. Contact Details Rainier Communications Michelle McMahon +1 781-718-3248 classiqPR@rainierco.com Company Website http://www.classiq.io/

April 23, 2024 08:00 AM Eastern Daylight Time

Capturing Consumer Spending on Health Care with XLV

Select Sector SPDR

With consumer spending on health care continuing to increase, the Health Care Select Sector SPDR Fund ( XLV ) provides an opportunity for investors to leverage this trend. XLV tracks health care stocks within the S&P 500 Index, offering broad exposure to core companies in the U.S. healthcare sector. The fund's top holdings* are comprised of market leaders across several sub-sectors of healthcare including companies such as Eli LIlly & Co (11.34%), Unitedhealth Group (8.36%), Johnson & Johnson (6.96%), Merck & Co (6.11%), AbbVie Inc. (5.87%), Thermo Fisher Scientific (4.10%), Abbott Laboratories (3.61%), Danaher Corp (3.00%), Pfizer (2.86%), and Amgen (2.78%). Growth Drivers in the Healthcare Sector As the health care sector continues to grow, these companies are well-positioned to benefit from increased consumer spending. The growth history in this sector has been driven by several factors, including a rise in chronic diseases, an aging population, and advancing medical technology. Total spending on health care rose from 16% of GDP in 2007 to an estimated 18% in 2023. Simultaneously, the total GDP has risen nearly 70% in that time, from 14.47 trillion in 2007 to 25.5 trillion in 2022. Investing in XLV offers a diversified way to capture steady consumer spending on health care. By investing in the health care market in a broad way, the ups and downs of a particular big name in the sector are mitigated by the exposure to other healthcare companies. DISCLAIMER: This is a work of research and should not be taken as investment or financial advice. Therefore, Select Sector SPDRs or the publisher is not liable for any decision made based on the publication. About the Company: Select Sector SPDR ETFs offer flexibility and customization opportunities. Many investors have similar outlooks, but no two are exactly alike. Select Sector SPDR ETFs let investors select the sectors that best meet their investment goals. *Holdings, Weightings & Assets as of 3/31/24 subject to change DISCLOSURES The S&P 500 Index is an unmanaged index of 500 common stocks that is generally considered representative of the U.S. stock market. The index is heavily weighted toward stocks with large market capitalizations and represents approximately two-thirds of the total market value of all domestic common stocks. The S&P 500 Index figures do not reflect any fees, expenses or taxes. An investor should consider investment objectives, risks, fees and expenses before investing. One may not invest directly in an index. Transparent ETFs provide daily disclosure of portfolio holdings and weightings All ETFs are subject to risk, including loss of principal. Sector ETF products are also subject to sector risk and nondiversification risk, which generally will result in greater price fluctuations than the overall market. Diversification does not eliminate risk. An investor should consider investment objectives, risks, charges and expenses carefully before investing. To obtain a prospectus, which contains this and other information, call 1-866-SECTOR-ETF (732-8673) or visit www.sectorspdrs.com. Read the prospectus carefully before investing. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is distributor for the Select Sector SPDR Trust. Media Contact: Company: Select Sector SPDRs Contact: Dan Dolan* Address: 1290 Broadway, Suite 1000, Denver, CO 80203 Country: United States Email: dan.dolan@sectorspdrs.com Website: https://www.sectorspdrs.com/ *Dan Dolan is a Registered Representative of ALPS Portfolio Solutions Distributor, Inc. ALPS Portfolio Solutions Distributor, Inc., a registered broker-dealer, is the distributor for the Select Sector SPDR Trust. SEL007449 EXP 5/31/24 Contact Details Dan Dolan +1 203-935-8103 dan.dolan@sectorspdrs.com Company Website https://www.sectorspdrs.com/

April 22, 2024 05:00 AM Eastern Daylight Time

Elsevier Appoints Dr Kieran West MBE as Executive Vice President of Strategy

Elsevier

Elsevier, a global leader in scientific information and analytics, announced today the appointment of Dr Kieran West MBE as Executive Vice President of Strategy, effective immediately. As an established senior executive with a track record of driving transformation and growth, Kieran joins Elsevier with extensive experience in healthcare, retail, consumer goods, and pharmaceuticals across international markets. Most recently, he served as Strategy Director at Bupa Global and UK, a leading healthcare provider and insurer, where he was instrumental in shaping the company's strategic direction. Prior to his time at Bupa, he served as an Associate Partner at McKinsey, where he advised both domestic and global companies on achieving commercial success. He previously taught mathematics at King’s College School, UK. His academic achievements include a PhD in History from the University of Cambridge, an MA in War Studies from King’s College London, and a PGCE degree in Mathematics. Kieran is also a world champion rower and Olympic gold-medallist, having won in the Men’s Eights in the 2000 Sydney Olympics. Kumsal Bayazit, CEO of Elsevier, said: “I am thrilled to welcome Kieran to Elsevier and look forward to the contribution that he will make with his strong strategic and operational experience, and his understanding of the healthcare, life sciences and academic communities. He is also passionate about developing individuals and delivering as a team, which is very much aligned with our values as an organization.” Kieran joins Elsevier’s Executive Leadership Team and will work across all areas of the company to develop and drive global strategic plans, including business development initiatives. He will be based in London. About Elsevier As a global leader in scientific information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making with innovative solutions based on trusted, evidence-based content and advanced AI-enabled digital technologies. We have supported the work of our research and healthcare communities for more than 140 years. Our 9,500 employees around the world, including 2,500 technologists, are dedicated to supporting researchers, librarians, academic leaders, funders, governments, R&D-intensive companies, doctors, nurses, future healthcare professionals and educators in their critical work. Our 2,900 scientific journals and iconic reference books include the foremost titles in their fields, including Cell Press, The Lancet and Gray’s Anatomy. Together with the Elsevier Foundation, we work in partnership with the communities we serve to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. For more information on our work, digital solutions and content, visit www.elsevier.com. Contact Details Dan DiPietro-James +1 323-252-0645 Dan.james@elsevier.com

April 22, 2024 04:00 AM Eastern Daylight Time

UNOS unveils new artwork honoring organ donors and recipients

United Network for Organ Sharing

Today, the United Network for Organ Sharing (UNOS) installed a mural by acclaimed artist Hamilton Glass to recognize the far-reaching impact of organ donation and to pay tribute to organ donors. The artwork is a Glass original, designed specifically for UNOS, and lives above the main entrance of UNOS’ headquarters in Richmond, Va. The mural portrays the interconnectedness of the organ donation and transplant community, with hands symbolizing the gesture of giving and receiving the gift of life. The blue ripples illustrate the ripple effect of donation on families and communities. “The artwork serves as a poignant reminder that every donation is a gift that touches us all, creating a network of support that UNOS tirelessly collaborates with daily to save lives,” said Glass. UNOS invited Richmond-based architect and artist Glass and his wife and business partner Taekia to design and create a piece of art that visually connects to and builds on the meaning of the National Donor Memorial. The memorial honors organ, eye and tissue donors and is open 24/7 to allow visitors to reflect on the journey of donation and transplant. “The lifesaving and lifechanging impact an organ donor has on both a recipient and their loved ones is incredibly profound, which is why we wanted to work with Hamilton Glass to create a piece of art that honors the selfless gifts organ donors provide,” said Maureen McBride, Ph.D., CEO of UNOS. “We want people to visit this mural and take in and learn how significant and impactful organ donation is.” Glass uses art to engage the public through big, bold designs and messages of hope, and has more than 300 murals on display throughout Richmond. The mural is approximately 16 feet tall and 40 feet wide and is comprised of 18 PVC panels. It is located on the exterior of UNOS’ building on North 4th Street in Richmond, Va. About UNOS United Network for Organ Sharing (UNOS) is the mission-driven non-profit serving as the nation’s transplant system under contract with the federal government. We lead the network of transplant hospitals, organ procurement organizations, and thousands of volunteers who are dedicated to honoring the gifts of life entrusted to us and to making lifesaving transplants possible for patients in need. Working together, we leverage data and advances in science and technology to continuously strengthen the system, increase the number of organs recovered and the number of transplants performed, and ensure patients across the nation have equitable access to transplant. Contact Details United Network for Organ Sharing Anne Paschke +1 804-782-4730 anne.paschke@unos.org Company Website https://unos.org

April 19, 2024 03:54 PM Eastern Daylight Time

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Hydrogen Utopia CEO discusses advances in cannabis operation and future hydrogen projects

Hydrogen Utopia International PLC

Hydrogen Utopia International PLC (LSE:HUI, OTCQB:HUIPF) CEO Aleksandra Binkowska joined Proactive's Stephen Gunnion to discuss progress at the company’s cannabis operation in Macedonia, highlighting two successful harvests and ongoing developments. Binkowska noted the company has a 49% option in Ohrid Organics, highlighting its impressive facilities and high-tech enhancements, including an advanced drying system that significantly improves product quality. Binkowska emphasized the importance of the location’s natural benefits and technological enhancements for achieving high-quality outputs. Currently, Hydrogen Utopia is awaiting laboratory results to officially confirm the product quality, which is necessary for obtaining the requisite governmental paperwork for product sales. She mentioned preparations for EU GMP certification audits, which will facilitate entry into the European market at higher certification levels, potentially allowing for a higher product price point. Furthermore, Binkowska outlined the financial success of Ohrid Organics, projecting earnings that would fund Hydrogen Utopia’s first waste plastics hydrogen facility. The profits from Ohrid could potentially finance this without additional capital raising, underscoring the strategic advantage of the investment. She also highlighted the supportive role of the Macedonian government in facilitating the company's initiatives in both the cannabis and hydrogen sectors. Contact Details Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

April 18, 2024 08:40 AM Eastern Daylight Time

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