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Centre for Neuro Skills Promotes Dr. Stefanie Howell to Director of Research Integration

Centre for Neuro Skills

Centre for Neuro Skills (CNS), a leader in traumatic brain injury and stroke rehabilitation services, today announced the promotion of Stefanie N. Howell, Ph.D., CBIS, to director of research integration. “Stefanie has been integral to Centre for Neuro Skills’ research program, looking closely at how we can not only improve the lives of our patients but people with brain injuries everywhere,” said David Harrington, president and CEO of Centre for Neuro Skills. “I’m excited to see the outcomes of our research efforts and how this can give us new insight into improving patient care. Since joining CNS in 2016, Howell has coordinated and designed clinical research studies, written manuscripts and provided education focused on methods for facilitating recovery and maximizing patient outcomes. Howell was promoted to Senior Neuroscientist in 2022 and now oversees the integration of CNS’ original research to expand understanding of brain injury, its causes and best treatment practices in the clinical setting. CNS’ ongoing research includes: Effects of Rehabilitation Following Traumatic Brain Injury (TBI) and Stroke CNS researchers evaluate the durability of outcomes obtained during post-acute rehabilitation following stroke and TBI. This will also determine if rehabilitation outcome is associated with future occupational status, life quality, cognitive function, and overall health, including rehospitalization. Traumatic Brain Injury and the Gut Microbiome Years after a brain injury, some individuals develop a complex set of conditions that prevent them from absorbing essential amino acids. The purpose of this study is to determine if altering the diet in these individuals can change their amino acid absorption and reduce symptoms and markers of neuroinflammation. Effects Of Aerobic Exercise and Rehabilitation After Traumatic Brain Injury Exercise contributes to overall health and protects and heals the brain, but the response to exercise may change after a brain injury. Through examining exercise and how it facilitates recovery, CNS hopes to determine the individual response to exercise (and how it has changed), in order to better tailor therapy to each person. Outcome Biomarkers After Brain Injury Patients consent to providing biological samples to help identify biomarkers in blood, saliva, and other tissues that will help CNS increase diagnostic and prognostic capabilities, tailor patient care and determine how much treatment is necessary. This study will allow clinicians to foresee potential risks that may inhibit recovery and aid intervention effectiveness, allowing CNS to better evaluate current and novel therapeutic interventions. Sleep Alterations After Traumatic Brain Injury and Stroke Sleep-wake disturbances have been identified in up to 80% of those with brain injuries. Sleep problems are linked to impaired attention, decreased cognitive functioning (including memory and attention) and overall diminished response to rehabilitation. This study will determine the nature of sleep-wake disturbances post injury. Researchers may then identify whether disturbances are related to the type, location, or time since the injury, as well as the impact sleep has on outcome and responsiveness to rehabilitation. Transcranial Direct Current Stimulation (tDCS) Following Traumatic Brain Injury This is a noninvasive technique of neurostimulation, which uses low amplitude direct current to alter brain cell firing. Studies suggest that tDCS is a painless technique for electrically stimulating the brain with almost no risk of harm. This form of therapy has been studied as a treatment modality for stroke patients but there is less evidence in literature for effectiveness in treating traumatic brain injury. This project will analyze the effects of a three-week program of tDCS on motor recovery and attention/concentration in individuals following a traumatic brain injury. To learn more about CNS and its research, visit www.neuroskills.com. *** About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Centre for Neuro Skills, visit: www.neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership or clinical staff, please contact Robin Carr at 415.766.0927 or CNS@landispr.com. # # # Contact Details Landis Communications Inc. Robin Carr +1 415-766-0927 cns@landispr.com Company Website https://www.neuroskills.com/

March 11, 2024 08:00 AM Pacific Daylight Time

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BenevolentAI CEO Dr Joerg Moeller discusses AI's impact on drug discovery

BenevolentAI

BenevolentAI CEO Dr Joerg Moeller tells Proactive's Stephen Gunnion how the company is positioning itself as a pioneer in AI-augmented drug discovery, aiming to enhance the success rates of drug development by identifying optimal targets early in the process. The company operates on three strategic pillars: advancing its proprietary pipeline of molecules for high medical need indications with limited treatment options, offering comprehensive drug discovery services through collaborations with notable industry partners such as AstraZeneca and Merck KGaA, and providing a Software as a Service (SaaS) platform for knowledge exploration. This multi-faceted approach not only drives BenevolentAI's scientific endeavours but also underpins its business model, which generates revenue through pipeline progression, collaboration milestones, and the innovative SaaS offering. A key example of the platform's validation is the repurposing of baricitinib, an Eli Lilly drug, for COVID-19 treatment based on BenevolentAI's insights. Dr Moeller's belief in AI's transformative potential in R&D is reinforced by the company's capabilities and the dedication of its team. Near-term milestones include anticipated results from a Phase 1a study of their lead program in ulcerative colitis, with strategic goals focusing on pipeline advancement, forging more partnerships, and exploring the viability of their SaaS model for sustainable growth. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

March 08, 2024 11:01 AM Eastern Standard Time

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Roberts & Ryan Inc. Joins NYSE and Welcomes the Mark J. Muller Equities Team to Strengthen Its Equity Trading Operations.

Roberts & Ryan, Inc.

Roberts & Ryan Inc., a Veteran Owned broker-dealer, is delighted to announce it has been approved for membership by the New York Stock Exchange and began operating today on the iconic NYSE trading floor. In conjunction with this milestone, the firm proudly introduces the esteemed Mark J. Muller Equities trading team to its floor operation. Comprising seasoned professionals including Mark Muller and Robert Moran, the team brings a wealth of experience and expertise to Roberts & Ryan Inc. The addition of the Mark J. Muller Equities trading team to the firm's already robust equity trading platform serves to fortify Roberts & Ryan's capabilities, reinforcing the company's commitment to anticipating and addressing client needs and concerns. Membership at the NYSE will empower the firm to harness broader liquidity pools, achieve parity in situational trading, and access real-time insights from point-of-sale access. These synergies, combined with Roberts & Ryan's existing institutional trading operation, will enhance the company's ability to serve equity clients effectively. Additionally, Roberts & Ryan will be well-positioned to assist clients during key price discovery events on the NYSE Floor, such as IPOs and secondary offerings. Founded on the core value of prioritizing competence, Roberts & Ryan Inc. places client satisfaction at the forefront of its operations. As a Veteran-Owned firm with the requisite certifications to fulfill all DEI mandates and set-asides, the company is dedicated to its social mission. A portion of all commission dollars earned is donated to foundations supporting Veterans and other deserving charities. Since 2018, this initiative has generated over $1.8 million in charitable contributions, benefiting more than 800 Veterans and their families. The combination of competency, diversity, and charity has enabled Roberts & Ryan Inc. to make a meaningful impact in the community. When asked to share his thoughts, Mark Muller, Managing Director of Roberts & Ryan's NYSE Floor Operations, remarked, "The Muller team is excited to be part of the Roberts & Ryan family, a firm that not only provides great service to its clients, but also supports our nation's Veterans and disadvantaged young adults. With our shared vision and commitment to excellence, we will continue to provide value-added executions from the floor of the NYSE." "With these strategic developments, Roberts & Ryan Inc. is poised to deliver enhanced services and value to our clients while upholding our commitment to excellence, integrity, and social responsibility," said Edward D'Alessandro, Chief Executive Officer of Roberts & Ryan, Inc. About Roberts and Ryan, Inc. Roberts & Ryan, Inc. is a Service-Disabled Veteran Owned (SDVO) broker-dealer with execution capabilities in the capital markets, equities, and fixed-income trading. The firm was founded in 1987 by a United States Marine Corps Vietnam combat veteran and Purple Heart recipient. With over $1.8 million in committed donations, Roberts & Ryan is active in donating to charitable foundations that make significant positive impacts in the lives of Veterans and their families, focusing primarily on general wellness, mental health, and career transition. To learn more about Roberts & Ryan, please visit www.roberts-ryan.com. Contact Details Roberts & Ryan, Inc. Sadie Millard, Chief Administrative Officer +1 646-542-0012 smillard@roberts-ryan.com Company Website https://www.roberts-ryan.com

March 04, 2024 12:00 PM Eastern Standard Time

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Centre for Neuro Skills Study Finds Differences in Sleep Patterns Between Men and Women with Post-Traumatic Brain Injury

Centre for Neuro Skills

Centre for Neuro Skills (CNS), a premier provider of traumatic and acquired brain injury rehabilitation services, has shared findings from a study researching sleep-wake disturbances, published in Neurotrauma Reports on January 3, 2024. They found that sleep deficits are correlated with poorer brain injury patient outcomes (verbal skills, depression issues), as monitored by therapists and administrators at CNS. The study included data from 57 individuals between the ages of 18-70 who sustained traumatic brain injuries (TBIs). CNS collected the data between 2018-2020 at its in-house sleep centers in Dallas and Bakersfield. “Overall, we found that lack of REM sleep negatively impacts memory and learning for TBI patients,” says Dr. Stefanie Howell, a neuroscientist at CNS. “In research, we must also consider additional variables that may impact our results. This includes biological variables such as sex, as biological sex does impact sleep. Our research found that women achieve REM sleep far less than men. Additionally, a decrease in REM sleep was associated with poorer learning and memory task performance, indicating a potential impact on outcome and recovery.” In addition to biological sex, CNS evaluated several sleep medications to determine if their use impacted sleep for TBI patients. Howell said “medications do not seem to be impacting results between men and women; however, the use of melatonin was associated with improved REM sleep and may therefore be of potential short-term benefit to TBI patients. It is important to note that over-the-counter melatonin options are variable due to formula ingredients.” “Through research, we’ve found that while sleep supplements in the benzodiazepine family may cause someone to fall asleep, they suppress REM sleep, which is crucial for memory recollection and improved learning,” says Dr. Brent Masel, executive vice president of medical affairs at CNS. “Melatonin was found to help improve REM sleep in the short term, but it’s important to note that long-term use can be habit-forming. I cannot stress this enough – the best medication is no medication.” In 2021, CNS published two other studies regarding sleep-wake disturbances post-stroke. The first evaluated the incidence of obstructive sleep apnea (OSA) and the second study considered the anatomical location of the injury (stroke). *** About Centre for Neuro Skills Centre for Neuro Skills is an experienced and respected world leader in providing intensive rehabilitation and medical programs for those recovering from all types of brain injury. CNS covers a full spectrum of advanced care from residential and assisted living to outpatient/day treatment. Founded by Dr. Mark Ashley in 1980, CNS has seven locations in California and Texas. For more information about Centre for Neuro Skills, visit: www.neuroskills.com, Facebook, Twitter, LinkedIn, YouTube. Media, please note: Visual assets, including photos, are available. To request an interview with CNS leadership or clinical staff, please contact Robin Carr at 415.766.0927 or CNS@landispr.com. # # # Contact Details Landis Communications Inc. Robin Carr +1 415-766-0927 cns@landispr.com Company Website https://www.neuroskills.com/

March 04, 2024 08:01 AM Pacific Standard Time

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TRUE Addiction & Behavioral Health: Elevating Standards of Care in Murfreesboro, Tennessee

TRUE Addiction & Behavioral Health

TRUE (Transforming Roots Unto Eternity) Addiction & Behavioral Health proudly announces its grand opening in Murfreesboro, Tennessee for individuals seeking comprehensive addiction and behavioral health services. Founded by Benjamin Dobbs, the facility stems from the urgent need for elevated standards of care in substance abuse and mental health treatment across the greater Nashville area. TRUE offers a spectrum of services addressing substance abuse, mental health disorders, and gambling and process addiction. Recent statistics underline the critical need for such services. According to the National Institute on Drug Abuse (NIDA), approximately 20.4 million adults in the United States battled a substance use disorder in 2019, with only about 10.3% receiving the specialized treatment they needed. Furthermore, NIDA indicates a concerning trend of increased drug overdose deaths with 92,000 fatalities recorded in 2020. Dobbs emphasizes, “As a leading substance abuse and mental health treatment facility, we are committed to delivering the highest quality care and fostering lasting recovery. Through evidence-based best practices and client-centered care, we equip individuals with the tools for transformation. Our approach delves into core beliefs, values, and connections, ensuring comprehensive support tailored to each client’s needs and fostering results-driven progress.” Programs offered: Partial hospitalization program (PHP): Intensive and structured care for individuals, ideal for those needing support beyond outpatient therapy without 24-hour hospitalization. Intensive outpatient program (IOP): Structured therapy and support while individuals continue living at home or in a supportive environment. Sober living homes: Structured housing offering additional accountability through drug tests and curfews, often utilized alongside PHP and IOP. Treatment services used in programs include: Cognitive Behavioral Therapy (CBT): Proven effective for various disorders, including depression, anxiety, and substance use issues. Dialectical Behavioral Therapy (DBT): Focused on managing emotions and relationships, particularly beneficial for addiction and self-harm. Holistic Therapy: Addressing physical, emotional, mental, and spiritual well-being for balanced development and coping skills. 12-Step Facilitation and Relapse Prevention: Customized aftercare plans and techniques to prevent relapse and sustain recovery. Additionally, TRUE plans to enhance community engagement among the clients with the upcoming opening of a 3,500-square-foot community center this spring. The center will feature a cafe, a 50-person meeting area, a meditation and yoga room, a lounge area, and a gaming area with ping pong, a pool table, and cornhole. These amenities are designed to aid in the healing process, promoting relaxation and stress reduction in clients between therapy sessions, as well as improving their comfort and ability to concentrate during therapy. TRUE Addiction & Behavioral Health in Murfreesboro, Tennessee, is dedicated to delivering compassionate and personalized care to individuals facing addiction and mental health challenges. Unlike standardized approaches, TRUE devises tailored treatment plans, equipping clients with the tools needed for lasting recovery. It stands as the only facility in Tennessee offering outpatient care for both mental health and substance abuse. For more information about programs and scheduling tours, visit https://trueaddictionbh.org/. Contact Details R Public Relations Madison Baber +1 210-213-2426 madison@rprfirm.com Company Website https://trueaddictionbh.org/

February 27, 2024 01:31 PM Eastern Standard Time

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Vaping: Know the Truth: Youth Vaping Prevention & Resources to Quit

YourUpdateTV

A video accompanying this announcement is available at: https://youtu.be/LXqBkJ5imDA E-cigarette use remains a public health threat among youth and young adults with more than 2.1 million middle and high schoolers currently using e-cigarettes, according to the 2023 National Youth Tobacco Survey. Nearly one in four students surveyed use e-cigarettes vape every day or nearly daily, underscoring the highly addictive nature of nicotine, which is harmful to developing brains. It doesn’t stop there. A recent study revealed that teen cannabis use has increased by 245% over the past two decades and approximately 15% of high school seniors who have ever used cannabis become daily or near daily users. On February 5th, a media tour was conducted featuring Amy Taylor, Chief of Community Engagement for Truth Initiative and teachers who use the Vaping: Know the truth curriculum. Vaping: Know the truth is a free, comprehensive digital curriculum designed to empower students by giving them the facts about the health dangers of e-cigarettes and providing resources for youth who vape to quit and made available to schools by leading social impact education innovator, EVERFI. Truth Initiative also recently added two new lessons to the Vaping: Know the truth curriculum to equip students with knowledge about the health effects of vaping cannabis. The new cannabis-focused lessons equip students with knowledge regarding cannabis in vaping products, including short- and long-term health effects, consequences, and risks. Since its launch, more than one million students across the country have actively engaged with the curriculum. It is a self-led interactive online course with peer-to-peer instruction. It was developed as part of Truth Initiative’s proven-effective and nationally recognized truth youth public education campaign. In addition to encouraging students to live vape-free lives, Vaping: Know the truth offers resources to help young people who are currently using e-cigarettes to quit through truth’s first-of-its-kind text message youth quit vaping program This is Quitting, which is already helping more than 700,000 youth and young adults on their journeys to quit. The curriculum also has suggested resources available for young people looking to quit cannabis. For more information, visit TRUTHINITIATIVE.ORG/VAPING-CURRICULUM Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

February 26, 2024 12:25 PM Eastern Standard Time

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Clearmind Medicine receives Patent Approval in China for treatment of binge behaviours

Clearmind Medicine Inc

Clearmind Medicine Inc CEO Dr. Adi Zuloff-Shani joined Steve Darling from Proactive to announce a significant milestone for the company: the granting of divisional patent approval by the China National Intellectual Property Administration (CNIPA). This latest patent approval solidifies Clearmind's patent protection for its flagship molecule and further establishes its extensive intellectual property (IP) protection in the psychedelic space. Clearmind's IP portfolio now encompasses fifteen utility patent families, including patents and applications with method of use and composition of matter claims. This includes 24 pending patent applications and 27 granted patents in key jurisdictions such as the US, Europe, China, and India. The company's robust IP portfolio positions it as a leader in the development of innovative treatments in the psychedelic field. Dr. Zuloff-Shani provided insights into Clearmind's flagship molecule, MEAI, which has shown promise in reducing the desire to consume alcoholic beverages while inducing a slight euphoric, alcohol-like experience. This treatment targets Alcohol Use Disorder, a prevalent condition characterized by an individual's inability to control their alcohol consumption despite negative consequences. MEAI also holds potential in addressing binge drinking, offering hope for individuals struggling with this harmful addiction. Clearmind plans to commence clinical trials for alcohol use disorder, expand their IP portfolio, and explore M E's potential in treating obesity. With collaborations with esteemed institutions like Johns Hopkins and Yale, Clearmind aims to revolutionize addiction treatment and offer innovative solutions to societal challenges. Stay tuned for their exciting developments in 2024. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

February 26, 2024 10:37 AM Eastern Standard Time

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Cardiff Lexington CEO Alex Cunningham Discusses Healthcare Growth Strategy

Cardiff Lexington Corporation

Cardiff Lexington CEO Alex Cunningham joined Steve Darling from Proactive to discuss the company's transformation into an acquisition-oriented healthcare firm with a focus on orthopedic surgery centers. Cardiff Lexington's revenue primarily stems from bodily injury and general liability insurance coverages, providing insulation from pricing downsides associated with Medicare and Medicaid. Cunningham emphasized the unique accounts receivable structure of the company, along with its focus on uninsured coverages, which contribute to maintaining high collectability rates. He also highlighted the increasing demand for orthopedic services driven by an aging population, positioning Cardiff Lexington for growth in this market. The company's recent financial performance showed significant increases in revenue, net earnings, and assets, reflecting its strategic focus and operational efficiency. Looking ahead to 2024, Cardiff Lexington plans to continue its expansion through acquisitions, market expansion initiatives, and strategic partnerships. Furthermore, Cunningham mentioned the company's plans to release its 10k in early March and pursue an uplift to a major exchange in 2024, with a clear focus on enhancing shareholder value and achieving strategic growth objectives. Contact Details Proactive North America Proactive North America +1 604-688-8158 NA-editorial@proactiveinvestors.com

February 26, 2024 10:32 AM Eastern Standard Time

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IQ-AI advances glioblastoma clinical trial, eyes phase two in 2025

IQ-AI Ltd

Dr Jennifer Connelly, MD, the Principal Investigator (PI) of the IQ-AI Limited sponsored phase one clinical trial that is being conducted at the Medical College of Wisconsin, joined Proactive's Stephen Gunnion with a positive update from its treatment for recurring glioblastoma patients. Connelly explained that glioblastoma, the most common malignant brain tumour, significantly impacts brain function, highlighting the importance of clinical trials to improve patient quality of life. The trial, opened nearly two years ago, investigates gallium maltolate, an oral medication showing promise in preclinical studies and animal models for efficacy against tumour cells. This phase focuses on drug tolerance, with patients reporting ease of use compared to traditional treatments and the ability to maintain normal daily activities. An expanded access programme (EAP), also known as compassionate use, has been launched by IA-AI subsidiary Imaging Biometric to allow wider access to gallium maltolate across the country, benefiting patients unable to travel to the Medical College of Wisconsin. The EAP, approved by the FDA, aims to collect additional safety and toxicity data, contributing to the trial's findings and supporting the progression towards a phase two clinical trial. The next milestone, by the end of 2024, involves concluding the phase one trial, determining the maximum tolerated dose, and preparing for the phase two trial slated for 2025, focusing on safety and beginning to evaluate efficacy. Contact Details Proactive UK Proactive UK +44 20 7989 0813 UKEditorial@proactiveinvestors.com

February 26, 2024 09:51 AM Eastern Standard Time

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