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Hong Kong Baptist University-led research identifies Salvia miltiorrhiza extract as potential preventive agent for gastric cancer induced by bile reflux

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 25 October 2022 - Research led by the School of Chinese Medicine at Hong Kong Baptist University (HKBU) has identified cryptotanshinone, a compound extracted from the Chinese herbal medicine Salvia miltiorrhiza, with the potential for the treatment and prevention of gastric cancer associated with bile reflux. The researchers unveiled the mechanism of how bile reflux induces gastritis and gastric cancer. They explained that refluxed bile acids (BAs) lead to the proliferation of pro-inflammation bacteria that promote gastric carcinogenesis, the formation of cancer. Professor Jia Wei, Associate Dean (International Collaboration) of Chinese Medicine and Cheung On Tak Endowed Professor in Chinese Medicine at HKBU, has identified cryptotanshinone with the potential for the treatment and prevention of gastric cancer associated with bile reflux. The research findings have been published in the international scientific journal Advanced Science. Role of bile reflux in gastric cancer unclear Bile, secreted by the liver, is stored in the gallbladder and is released to the duodenum to help digest fat. When the pylorus connecting the stomach and the duodenum is damaged or fails to work properly, bile in the duodenum can enter the stomach, causing gastritis. People with stomach surgery complications, peptic ulcers or gallbladder removal surgery have higher risks of bile reflux. However, the mechanism of how bile reflux induces gastric carcinogenesis remains unclear. Professor Jia Wei, Associate Dean (International Collaboration) of Chinese Medicine and Cheung On Tak Endowed Professor in Chinese Medicine at HKBU, in collaboration with researchers from Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, conducted a study on how bile reflux induces gastric carcinogenesis, and looked for new prevention and therapeutic approaches. Professor Jia said: “We unveiled for the first time the underlying mechanism by which bile reflux promoted the development of gastric carcinogenesis. It offers important clinical insights on the development of novel prevention and therapeutic approaches for the disease. Based on the newly discovered mechanism, we identified cryptotanshinone as a potential Chinese medicine-based pharmaceutic agent for the prevention and treatment of gastric carcinogenesis due to bile reflux.” Bile reflux alters gastric environment The research team analysed the gastric juice samples of 50 patients with bile reflux gastritis (BRG group), 50 patients with gastric cancer (GC group) and 45 subjects in the control group using chromatography and mass spectrometry techniques. It was found that the amounts of BAs, the major component of bile, in the gastric juice samples of BRG and GC groups are significantly higher than in the control group. Furthermore, the acidities of gastric juice samples of the BRG group (pH value about 3.5) and the GC group (pH value about 4) are drastically lower than in the control group (pH value about 2). The phenomenon is explained by the fact that BAs are weak acids compared with strong gastric acid, and their influx into the stomach changed the gastric environment by upsetting the normal acid-base balance of the gastric juice. Further investigation found that a specific type of BA, called taurodeoxycholic acid (TDCA), showed a strong positive correlation with pH value of gastric juice samples of the BRG and GC groups. Previous studies showed that bile reflux is closely related to chronic gastric inflammation and gastric carcinogenesis. The researchers thus examined the concentrations of lipopolysaccharide (LPS), a pro-inflammation cytokine, in the gastric juice of the 145 subjects above, and found that the BRG and GC groups have LPS concentrations significantly higher than those of the control group. Change in microbiota associates with gastric carcinogenesis As LPS is produced and found in the outer membrane of certain kinds of bacteria, the researchers applied gene sequencing and other techniques and confirmed that LPS-producing bacteria are significantly more abundant in the gastric juice of BRG and CG groups compared to the control group. Among these LPS-producing bacteria, a species called P. melaninogenica had the highest relative abundance. From these experimental results, it is suggested that bile reflux induces significant changes in the gastric environment, alters the gastric microbiota, and results in the development of gastritis and gastric carcinogenesis. The hypothesis was tested with a series of in vitro and in vivo experiments in mice, which confirmed that application of TDCA and LPS promotes gastric epithelial cell proliferation, and induces gastric inflammation. Cellular and molecular analysis revealed that P. melaninogenica promoted gastric inflammation in mice by activating the IL-6/JAK1/STAT3 pathway, a chain of interactions between proteins in a cell involved in processes such as immunity, cell division, cell death, and tumour formation. Cryptotanshinone as potential pharmaceutic agent After unveiling the mechanism of bile reflux-induced gastric cancer, the researchers turned to explore a corresponding preventive and therapeutic approach. They focused on cryptotanshinone, a bioactive compound isolated from the roots of Salvia miltiorrhiza, which is a Chinese herbal medicine that facilitates blood circulation with an anti-inflammatory effect. Cryptotanshinone is also known as an inhibitor of the STAT3 signaling pathway in cells. The researchers tested the effects of cryptotanshinone with a bile reflux mouse model developed through surgery. In a group of eight mice without application of cryptotanshinone, three mice developed gastric lesions 50 weeks after surgery. However, in another group of six mice injected with cryptotanshinone, no obvious gastric lesions were observed. The results suggested that cryptotanshinone has abolished the effects of TDCA and LPS in activating the IL-6/JAK1/STAT3 pathway. “Based on the research findings, it can be concluded that cryptotanshinone is a potential Chinese medicine-based pharmaceutic agent for the prevention and treatment of gastric carcinogenesis due to bile reflux. It provides an alternative strategy for the development of medication which targets on the newly discovered mechanism of how bile reflux induces gastric carcinogenesis,” said Professor Jia. Contact Details HKBU Communication and Public Relations Office Christina Wu hkbunews@hkbu.edu.hk

October 25, 2022 09:00 AM Eastern Daylight Time

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A Growing Body of Research Supports the Positive Impact of Massage Therapy For Mental Health

American Massage Therapy Association

The American Massage Therapy Association (AMTA) is sharing recent research supporting the benefits of massage therapy for stress, anxiety and depression. In a time when the Anxiety and Depression Association of America (ADAA) ranks anxiety as the country’s most common mental illness – and depression as the leading cause of disability for people ages 15 to 44 1, people with mental health issues are turning to a range of wellness strategies, including massage therapy which has a positive impact on the body and mind. During AMTA’s National Massage Therapy Awareness Week®, explore the latest studies on massage therapy for mental health. Studies on Massage for Stress and Anxiety A recent study by German researchers indicated that short-term interventions such as massage therapy can robustly reduce stress on a psychological and physiological level by boosting the body’s principal engine for relaxation – the parasympathetic nervous system. In the study, researchers measured how massage can affect heart rate variability. When the parasympathetic nervous system is active, during rest and relaxation, the heart rate variability is high. The researchers found that just 10 minutes of massage created “significant increases” in heart rate variability. 2 Another 2021 Mayo Clinic study showed positive results on the benefits of massage therapy for anxiety in preoperative surgical patients. After receiving a 15-minute non-therapeutic hand massage, patients experienced lower anxiety levels and increased satisfaction. 3 New Research on Massage Therapy for Chronic Pain and Depression Research also indicates that massage can improve mood and reduce depression in those living with chronic pain. In fact, a scientific journal “Brain Sciences” recently covered a 2020 trial on women with chronic back pain whose depressive symptoms and negative body image were significantly reduced after receiving slow, superficial strokes along the back, neck and dorsal limbs. 4 In addition, a recent Australian pilot study examined the feasibility and acceptability of partner-delivered relaxation massage, and whether massage can reduce symptoms of prenatal anxiety, stress and depression. The results showed that massage therapy was linked to a large reduction in anxiety and depression symptoms and a moderate reduction of stress. Pregnant women who received massage therapy reported a positive benefit from massage of 78 mm (range 29 – 100) on a 100 mm visual analog scale. 5 Massage For Youth Struggling with Mental Health Issues Mental health issues are on the rise for children in the U.S. Many recent studies point to the benefits of using massage in addressing a range of psychological issues in youth, such as attention disorders, aggression, anxiety, depression and post-traumatic stress disorder. In a 2019 study on eating disorders and depression, researchers found that excessively low-dopamine levels were increased following one month of daily 20-minute massages. 6 Another 2019 study compared the effectiveness of soft tissue manipulation and a relaxation technique (Jacobson’s progressive relaxation) in reducing anxiety levels in young adults. The researchers found that the level of perceived anxiety decreased “significantly” in the group receiving soft tissue manipulation. 7 “Research on the efficacy of massage therapy for mental health continues to show great promise,” says Michaele Colizza, AMTA National President. “In fact, more and more consumers are turning to massage therapy as part of an integrative approach to care for improving mental health and well-being.” It’s an Important Moment in Time for Massage for Mental Health Over the last few years, the COVID-19 pandemic has had a marked effect on the country’s mental health. According to the U.S. Census Bureau, more than 42% of people surveyed reported symptoms of anxiety or depression during the pandemic. Researchers are concerned that the increase in mental health issues could linger long after the pandemic has subsided, and many integrative health experts believe that massage therapy can be an important part of the solution in helping alleviate stress, anxiety and depression. 8 About The American Massage Therapy Association The American Massage Therapy Association, the most trusted name in massage therapy, is the largest non-profit, professional association serving massage therapists, massage students and massage schools. The association is directed by volunteer leadership and fosters ongoing, direct member-involvement through its 51 chapters. AMTA works to advance the profession through ethics and standards, the promotion of fair and consistent licensing of massage therapists in all states, and public education on the benefits of massage. To find a qualified massage therapist in your area, please visit AMTA’s Find a Massage Therapist Locator Service ™. Research Citations 1. Anxiety & Depression Association of America (ADAA): Facts & Statistics | Anxiety and Depression Association of America, ADAA 2. University of Konstanz. “Ten minutes of massage or rest will help your body fight stress.” ScienceDaily. September 2020. http://www.sciencedaily.com/releases/2020/09/200918104305.htm. 3. Zghihong, Bauer, Aaberg, Pool, Van Rooy, Schroeder, Finney. “Benefits of hand massage on anxiety in preoperative outpatient: A quasi-experimental study with pre- and post-tests.” https://pubmed.ncbi.nlm.nih.gov/32919894/ 4. Effect of Psycho-Regulatory Massage Therapy on Pain and Depression in Women with Chronic and/ or Somatoform Back Pain: A Randomized Controlled Trial - PubMed (nih.gov) 5. Hall HL, Munk NK, Carr BH, Fogarty SR, Cant RB, Holton SR, Weller CL, Lauche RM. Maternal mental health and partner-delivered massage: A pilot study. Women Birth. 2021 May;34(3):e237-47. 6. Tiffany Field. " Pediatric massage therapy research: A narrative review." Children (Basel) 2019 Jun; 6(6): 78. 7. Wilczynska, Lysak-Radomska, Podczarska-Glowacka, Jolanta Zajt, Dornowski, Skonieczny " Evaluation of the effectiveness of relaxation in lowering the level of anxiety in young adults." Int J Occup Med Environ Health 2019;32(6):817-824. 8. Vahration, Blumberg, Terlizzi, Schiller. “Symptoms of Anxiety or Depressive Disorder and Use of Mental Health Care Among Adults During the COVID-19 Pandemic” – United States, August 2020-February 2021. MMWR Morb Mortal Wkly Rep 2021;70:490-494. https://www.cdc.gov/mmwr/volumes/70/wr/mm7013e2.htm?s_cid=mm7013e2_w Contact Details American Massage Therapy Association Kristin Taylor +1 847-905-1425 communications@amtamassage.org Company Website https://www.amtamassage.org/

October 24, 2022 12:50 PM Eastern Daylight Time

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AmeriLife’s The Senior Resource Group Acquires Secure Benefits to Accelerate Growth

AmeriLife

The Senior Resource Group, (SRG), a leading, national field marketing organization (FMO) for the industry’s top insurance carriers and an affiliate of AmeriLife Group, LLC (“AmeriLife”), announced today that it has acquired Secure Benefits, a Florence, Ala.-based field marketing organization (FMO). Per the agreement, terms of the deal were not disclosed. “We met [Secure Benefits owner and CEO] Stephanie Kirk for lunch a few years ago and we connected from day one,” said Shane Souders, co-founder and managing partner of The Senior Resource Group. “She’s an exceptional leader and businessperson, who has a selfless passion – one that is perfectly aligned with SRG’s mission – to help her brokers and employees succeed in this industry. We’re excited to grow together with Secure Benefits and proud to call them our partner.” Founded in 2010 by Kirk, Secure Benefits specializes in distributing Medicare Advantage solutions to beneficiaries throughout Alabama and Tennessee. As an “agent-first” organization, Secure Benefits prides itself on nurturing longstanding, successful agents and cultivating a family-oriented culture that’s become the hallmark of its brand and business. The acquisition expands The Senior Resource Group’s geographical footprint while bringing Secure Benefits under the umbrella of AmeriLife’s all-star distribution network. The deal also provides Secure Benefits – alongside its partners Benefits Solutions Group, Senior Benefits Advisors, Silver Benefit Solutions and The Providence Group – with access to SRG’s and AmeriLife’s industry-leading technology, tools, resources and top-level contracts to help them grow and thrive. “Over the past 14 years, Secure Benefits has steadily grown to include agents in multiple states across the Southeast,” said Kirk. “We’re not your typical FMO – our agents and team members are like family, many of whom have been with us since the beginning. We’re proud of our focus on helping agents build strong businesses and ensuring they feel fully supported. We’re thrilled to partner with Shane, SRG and AmeriLife, and look forward to the many opportunities ahead of us.” “We’re excited to welcome Secure Benefits and its partners to the AmeriLife family,” added AmeriLife Chief Distribution Officer Mike Vietri. “Under Shane’s leadership, there’s no doubt that they will continue to thrive and help accelerate AmeriLife’s mission of helping people live longer, healthier lives.” Secure Benefits will continue to operate as a stand-alone organization out of its Florence headquarters and under the leadership of Kirk, who will report to Souders. ### About The Senior Resource Group The Senior Resource Group was founded in 2008 by insurance brokers who understand the needs of agents in the field. Today, The Senior Resource Group is a premier field marketing organization for an array of national insurance carriers providing Medicare Supplement policies, Medicare Advantage plans, life insurance, final expanse plans and financial products in 25 states. The team at The Senior Resource Group provides the tools, support and training necessary for success in the insurance industry. For more information, visit TheSeniorResourceGroup.com. About Secure Benefits Founded 14 years ago by Stephanie Kirk, Secure Benefits is a leading and growing Medicare Advantage solutions field marketing organization (FMO) that serves agents and their communities across the southeast United States. Based in Florence, Ala., with additional offices in Lebanon, Tenn., Secure Benefits is an “agent-first,” family-focused FMO that emphasizes education, advocacy and relationship building to help its agents deliver on their promise to their clients. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and more than 100 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. Contact Details Media Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Partnership Inquiries Patrick Nichols +1 727-726-0726 pnichols@amerilife.com Company Website https://amerilife.com/

October 24, 2022 09:00 AM Eastern Daylight Time

NASDAQ: AGRX Agile Therapeutics Anticipates Increased Growth In Q3 of 2022

Agile Therapeutics, Inc.

Contact Details Matt Riley - Head of Investor Relations & Corporate Communications mriley@agiletherapeutics.com Company Website https://agiletherapeutics.com/

October 21, 2022 11:00 AM Eastern Daylight Time

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Stuttering Foundation Marks 75th Anniversary, International Stuttering Awareness Day with New Resources

The Stuttering Foundation

October 22 nd is International Stuttering Awareness Day (ISAD), observed worldwide with a focus on stuttering--a speech disorder characterized by repetition of sounds, syllables, or words; prolongation of sounds; and interruptions in speech known as blocks. This year also marks the 75 th Anniversary of the Stuttering Foundation, founded by the late entrepreneur and philanthropist Malcolm Fraser in 1947, making it the first and largest nonprofit charitable organization in the world working toward the prevention and improved treatment of stuttering. The Foundation is renowned globally for its trusted and timely resources--many available free on its website: StutteringHelp.org. To mark its 75 th anniversary and in observance of International Stuttering Awareness Day, the Stuttering Foundation officially raised its estimate of people who stutter to 80 million people --representing one percent (1%) of the global population. “When my father Malcolm founded the Stuttering Foundation back in 1947, there were an estimated 25 million people who stutter across the globe,” said Jane Fraser, president of the Stuttering Foundation and Malcolm’s daughter. “Today, we raise our estimate to 80 million people who stutter worldwide, more than three times the number from when we began. Over the decades, we’ve expanded our outreach and added many resources for people in more than 137 countries around the world.” The Stuttering Foundation marked the auspicious occasions with the release of: Ask the Stuttering Foundation --This new YouTube channel addresses the dozens of inquiries received by the Foundation daily by telephone, email, and generated on our website. Some of the queries are more common such as parents who are concerned when their preschoolers begin to stutter, or people who stutter of any age reaching out to learn from others who also stutter. Some requests are less common such as pediatricians or speech-language pathologists looking for help for patients with specific needs. Whatever the content, we respond to meet the needs of people who stutter around the globe. For Kids By Kids 2.0 --This lively and engaging 10-minute video features interviews with real students who stutter, speaking opening about their stutter, dealing with teasing, sharing what helps them, and showing how to teach others about stuttering. An animated skateboarder named Kyle narrates the film. The ABCs of Stuttering --This 10-minute video helps parents and teachers understand how stuttering can affect children of all ages in the classroom and is now available for free on the Stuttering Foundation’s YouTube channel. The highlight of the video is the students--Umberto, Kate and Martin--talking openly about their stutter and what helps make them feel more comfortable talking in the classroom. “For more than seven decades, the Stuttering Foundation has served as a trusted resource for the stuttering community, offering brochures, e-books, podcasts, videos, a magazine, virtual learning sessions and multiple social media channels to spread timely and accurate information about stuttering,” added Fraser. About the Stuttering Foundation Malcolm Fraser, a successful businessman who struggled with stuttering, established the nonprofit Stuttering Foundation in 1947 and endowed it throughout his lifetime. The Foundation provides free online resources at StutteringHelp.org for people who stutter and their families, as well as support for research into the causes of stuttering. Visit www.StutteringHelp.org. Contact Details The Stuttering Foundation Greg Wilson +1 571-239-7474 greg@curleycompany.com

October 19, 2022 01:00 PM Eastern Daylight Time

News Release

Consumers Are Demanding More From Cannabis Companies — Here’s What Some Are Looking For

LiveWire Ergogenics, Inc.

The cannabis industry has undergone drastic changes in recent years, and as marijuana becomes more mainstream, consumers are demanding more from cannabis companies. No longer are the days when consumers will settle for a plastic zip lock bag of questionable quality and purity underground weed — they want choices that reflect their lifestyle and values. Many consumers report that they want a high-quality lifestyle brand and one of the things they are looking for is an organic, hand-cut, pesticide-free, and easy-to-consume cannabis product. Companies that embody these values will be better positioned to become the go-to products for more consumers. Why Do Consumers Want Lifestyle Brands? A growing percentage of consumers care more about the quality and sustainability of the brands they engage with. In a recent survey by Stifel and Morning Consult, more than half of the survey’s respondents shared they had bought from a new brand specifically for its transparent, environmentally responsive, and sustainable practice. When it comes to the cannabis industry, there is a preference for hand-trimmed and hand-grown cannabis. Colloquially known as craft cannabis, companies willing to prioritize hand-trimmed cannabis grown without pesticides and machines will have an easier task of creating high-end products that consumers flock to. Cannabis companies would be wise to look to the lifestyle brand journey of other consumer packaged goods (CPG). Researchers see lots of comparisons between the growth of lifestyle brands in high-end coffee companies and the cannabis industry. Similarly to how high-end coffee consumers are more loyal to brands that boost sustainable heritage, product origins, ethical sourcing, and roasts, a growing number of cannabis consumers are following suit. California is in the process of implementing a product origin program similar to the California wine industry for cannabis. Companies that can leverage a consumer-centric approach to the cannabis industry might find success in the coming years as luxury cannabis becomes more available and accessible to the public. What Companies Are Doing It Right? LiveWire Ergogenics Inc. (OTCMKTS: LVVV) (“LiveWire”) is a company that focuses on acquiring and managing special-purpose real estate properties that qualify for the discovery and development of high-end organic cannabis products. Because of this focus on selecting compliant real estate, LiveWire can hone in on projects that allow for high-end cultivation and set the Company apart from the competition, especially from mass producers of low-quality products. In order to operate economically, LiveWire has developed its Estrella Ranch as the central hub for all LiveWire and subsidiary operations. The Estrella Ranch’s location is ideal for cultivating a high-end organic-style product in a micro-climate that can allow for all-year-round production. Its tractor-less operation is focused on producing high-quality, hand-crafted outdoor products. Additionally, the property’s ultimate goal is to be the world’s first Estate Grown Weedery, an ultimate cannabis destination. This goal aligns well with the Company’s health and wellness lifestyle value. Consumers want an experience from their lifestyle brand of choice, and LiveWire seems to be an example of a company positioning itself well to deliver. The Company focuses on acquiring, managing, and licensing well-qualified cannabis real estate locations to establish fully compliant and permitted facilities to produce cannabis-based products and establish relationships for the statewide distribution of these products in California. This includes developing and licensing high-quality organic cannabinoid-based products and services and creating the high-quality "Estrella Grown Weedery™" brand via its subsidiary/affiliate companies Estrella Ranch Partners, Estrella River Farms, Makana Ola, and CaliCruz Farms. LiveWire Ergogenics does not produce, sell, or distribute products that violate the United States Controlled Substances Act. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Tristan Cavato ir@livewireergogenics.com

October 19, 2022 09:24 AM Eastern Daylight Time

LMCC Returns October 20 & 21 To Hudson Yards: Presenting The World’s Top Cannabis & CBD Beauty, Wellness, Food & Beverage Brands

LMCC Ventures LLC

New York, NY, October 18, 2022 — Luxury Meets Cannabis Conference (LMCC) today announced the complete program for its Fall 2022 Edition, which returns on October 20 & 21 in Hudson Yards, New York City. Launched in 2018 as a first-of-its-kind B2B trade event, LMCC has grown into the go-to resource and venue for product discovery and extensive category education, connecting visionary CBD and Cannabis brands across the beauty/wellness, food/beverage, and technology/lifestyle accessory categories to mainstream retailer buyers, luxe dispensaries, media, and investors. As an indication of the excitement around the emerging New York legal Cannabis market and the official brand showcase mix at LMCC, 100+ A-tier retail outlets – LMCC’s highest rate to date – have registered to attend the show including KITH, Standard Dose, Curaleaf, Bloomingdale’s, Rise Cannabis, Etain, The Vitamin Shoppe, Shen Beauty, and many others. LMCC’s inaugural infused Food & Beverage Hall will also debut, which will feature the finest food/culinary, beverage, consumables, and confectionery brands in the space — especially timely as alcohol sales in the U.S. continue to decline. This Harrods-esque, immersive (and delectable) experience will spotlight leading brands such Cann, Kiva Confections, oHHo, Cycling Frog, Cloud 11, Black Dahlia, L8, Sass, Chef For Higher, and many more. More than 700 business attendees from around the world will explore the LMCC Official Brand Showcase — a pre-vetted, store-ready exhibition — paired with a full schedule of keynote talks, brand presentations, and business networking. For the most up-to-date information on partners, exhibiting brands and speakers, visit lmccshow.com. LMCC FALL 2022 OFFICIAL BRAND SHOWCASE DIRECTORY Astraèa & Co. Black Dahlia CANDOR CANN Chef for Higher Cloud 11 Cycling Frog Daily Habit Drew Martin errbshop Franny’s Farmacy Function Botanicals The Healing Rose Hudson Cannabis Innocan Pharma K’dara Kiva L8 LEUNE LumiBloom MĀSK Skincare oHHo Plantwise REUNION Sackville & Co. SASS StellaVia Stone Road UB Super / Meticulous Skincare WALALA LMCC SPEAKER SCHEDULE NOW LIVE See 50 leading executives on stage from Ulta Beauty, Adweek, New York State Cannabis Control Board, Merida Capital Holdings, Adweek, Different Leaf, NYC Mayor’s Office, Food & Wine, Standard Dose, Women’s Health, and Bon Appétit and many others: View LMCC Fall 2022 Speaker Schedule Here ### Attendee Tickets: Two-day, all-access passes to LMCC 2022 are $695. Purchase passes HERE. Retail Buyer Registration: Admission is complimentary only for qualified retail buyers and their teams. Stores, dispensaries, and e-tailers only can register HERE. Sponsors: LMCC is proud to partner with Merida Capital Holdings Brand Applications: Now Accepting Submission for LMCC May 2023 Brands Can Now Reserve Space for LMCC 2023 Here About LMCC: Founded in 2018, LMCC Ventures LLC is the parent company of the annual Luxury Meets Cannabis* Conference (LMCC) in New York City. LMCC is the premier B2B event connecting A-tier retailers, media, investors, leading dispensaries and CPG executives to premium CBD, hemp and Cannabis brands — with a keen focus on beauty, wellness, food & beverage. Past participants include retailers like Sephora, Nordstrom, Credo Beauty, and Bloomingdale’s; media including The New York Times, Glossy, Travel & Leisure, O, The Oprah Magazine, and Robb Report; and speakers from Mitch Baruchowitz (Merida Capital Holdings) and Cindy Capobianco (Lord Jones) to Bobbi Brown and Frederic Fekkai. For more information on LMCC, visit lmccshow.com. Find LMCC socially on LinkedIn and Instagram. Guidelines & Legal: no smoking or vaping on any kind permitted inside the venue. Local laws strictly apply. Contact Details Katie Shapiro +1 303-882-5596 katie@katieshapiromedia.com Company Website https://www.lmccshow.com/

October 19, 2022 09:00 AM Eastern Daylight Time

Chill Brands kicks off "new era" with website relaunch

Chill Brands Group PLC

Contact Details Proactive Proactive UK Ltd +44 20 7989 0813 uk@proactiveinvestors.com

October 19, 2022 06:51 AM Eastern Daylight Time

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Are You Paying Too Much for Your Medicare Plan?

YourUpdateTV

October 15 marked the start of the Medicare Annual Enrollment Period — a time for Medicare-eligible people to choose the plan that best supports their unique needs and budget. Recently, Vice President of Aetna Medicare Bob O’Connor, participated in a nationwide satellite media tour to discuss what you need to know for thisAnnual Enrollment Period. A video accompanying this announcement is available at: https://youtu.be/jriqOx0-9pc With the national inflation rate at an all-time high since the 1980s, it’s more important than ever for older adults, who are often on a fixed income, to evaluate their individual health care needs and choose a Medicare plan that best supports those needs in a cost-effective way. The 2022 Health Care Insights Study by CVS Health found that 90 percent of providers said cost of care is a top concern for their 65-and-older patients. Medicare can be confusing because there are a lot of different options out there. And if you’re around Medicare age, your mailbox will soon be flooded with Medicare plan letters, postcards and ads. Think about what’s important to you and ask yourself some basic questions, like does the plan fit your budget and does your plan cover your doctors, hospitals, and pharmacies? Another important thing to consider is prescription drugs. Are there prescription drugs you take regularly? Does the plan’s drug list cover those prescriptions? It’s also important to know what tier your prescription drugs are on or whether there are any coverage rules. The first thing people should do is go to the Medicare.gov website. Once there, they can enter their zip code and see all the Medicare plans available in their area. And of course, you can learn more about 2023 Aetna Medicare plans at AetnaMedicare.com or call us at 1-844-588-0041 (TTY: 711), 7 days a week, 8 AM to 8 PM. The Medicare Annual Enrollment Period runs from October 15 through December 7, 2022. A licensed agent may answer your call. About Bob O’Connor As Vice President of Aetna Medicare and community volunteer for organizations focused on seniors and the disabled, Bob O’Connor brings a unique perspective to the Medicare conversation. He’s worked in several roles at Aetna in support of seniors and currently oversees member experience, quality and business strategy for Aetna’s robust portfolio of Medicare Advantage plans. An advocate for the aging population, Bob is passionate about improving health care and helping Aetna’s more than 10.6 million Medicare members nationwide achieve their best health. Contact Details YourUpdateTV +1 212-736-2727 yourupdatetv@gmail.com

October 18, 2022 12:37 PM Eastern Daylight Time

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